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EC Tree
IUBMB Comments The enzyme from the prune mite Carpoglyphus lactis also acts on geraniol with greater activity [cf. EC 1.1.1.347, geraniol dehydrogenase (NAD+)]. Unlike EC 1.1.1.216, farnesol dehydrogenase (NADP+), this enzyme cannot use NADP+ as cofactor.
The enzyme appears in viruses and cellular organisms
Synonyms
farnesol dehydrogenase, GeDH, NAD+-farnesol dehydrogenase,
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NAD+-farnesol dehydrogenase
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(2E,6E)-farnesol + NAD+ = (2E,6E)-farnesal + NADH + H+
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(2E,6E)-farnesol:NAD+ 1-oxidoreductase
The enzyme from the prune mite Carpoglyphus lactis also acts on geraniol with greater activity [cf. EC 1.1.1.347, geraniol dehydrogenase (NAD+)]. Unlike EC 1.1.1.216, farnesol dehydrogenase (NADP+), this enzyme cannot use NADP+ as cofactor.
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(2E,6E)-farnesol + NAD+
(2E,6E)-farnesal + NADH + H+
3-methyl-2-buten-1-ol + NAD+
3-methyl-2-butenal + NADH + H+
4.3% of the activity compared to geraniol
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-
?
citronellol + NAD+
?
4.3% of the activity compared to geraniol
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?
geraniol + NAD+
geranial + NADH + H+
geranylgeraniol + NAD+
? + NADH + H+
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?
additional information
?
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straight-chain alcohols such as 1-octanol, 2-buten-1-ol, 1-butanol and ethanol serve as poor substrates
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?
(2E,6E)-farnesol + NAD+
(2E,6E)-farnesal + NADH + H+
highest affinity for the active site of the FLDH enzyme, FLDH-encoded enzyme does not exhibit appreciable farnesal reductase activity
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ir
(2E,6E)-farnesol + NAD+
(2E,6E)-farnesal + NADH + H+
key enzyme in biosynthesis of the alarm pheromone neral
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-
?
(2E,6E)-farnesol + NAD+
(2E,6E)-farnesal + NADH + H+
50% of the activity compared to geraniol
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-
?
(2E,6E)-farnesol + NAD+
(2E,6E)-farnesal + NADH + H+
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-
-
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?
geraniol + NAD+
geranial + NADH + H+
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?
geraniol + NAD+
geranial + NADH + H+
nerol, the geometrical isomer of geraniol is inactive. The enzyme cannot use NADP+ as cofactor
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?
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(2E,6E)-farnesol + NAD+
(2E,6E)-farnesal + NADH + H+
(2E,6E)-farnesol + NAD+
(2E,6E)-farnesal + NADH + H+
key enzyme in biosynthesis of the alarm pheromone neral
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?
(2E,6E)-farnesol + NAD+
(2E,6E)-farnesal + NADH + H+
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?
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NAD+
the enzyme cannot use NADP+ as cofactor
NAD+
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dependent on NAD+, cannot be replaced by NADP+
NAD+
no oxidation observed in the presence of NADP+
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0.051
geraniol
pH 8.5, 22°C
0.0595
NAD+
pH 8.5, 22°C
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2996
geraniol
pH 8.5, 22°C
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58400
geraniol
pH 8.5, 22°C
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8 - 10.5
pH 8.0: about 75% of maximal activity, pH 10.5: about 35% of maximal activity
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5 - 60
5°C: about 50% of maximal activity, 60°C: about 50% of maximal activity
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UniProt
brenda
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UniProt
brenda
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brenda
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brenda
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brenda
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brenda
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physiological function
key enzyme in biosynthesis of the alarm pheromone neral
physiological function
results suggest that FLDH is a negative regulator of ABA signaling
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GEDH_CARLC
378
0
40630
Swiss-Prot
other Location (Reliability: 5 )
A0A5B7ADP3_DAVIN
411
0
45340
TrEMBL
other Location (Reliability: 4 )
A0A2P6Q0F4_ROSCH
338
0
37201
TrEMBL
Mitochondrion (Reliability: 3 )
A0A5B7AB33_DAVIN
128
0
14006
TrEMBL
other Location (Reliability: 3 )
A0A5B7CCC3_DAVIN
204
0
21668
TrEMBL
Mitochondrion (Reliability: 2 )
A0A5B7ABA9_DAVIN
408
0
45270
TrEMBL
other Location (Reliability: 4 )
A0A5B7AC03_DAVIN
251
0
27696
TrEMBL
Secretory Pathway (Reliability: 3 )
G7J6B7_MEDTR
333
0
36558
TrEMBL
Mitochondrion (Reliability: 3 )
A0A2P6QV66_ROSCH
55
0
6369
TrEMBL
Secretory Pathway (Reliability: 5 )
A0A5B7AFW0_DAVIN
408
0
45255
TrEMBL
other Location (Reliability: 4 )
A0A5B7AB94_DAVIN
408
0
45219
TrEMBL
other Location (Reliability: 4 )
A0A5B7BEB5_DAVIN
338
0
36895
TrEMBL
Mitochondrion (Reliability: 2 )
A0A2P6Q5A9_ROSCH
78
0
9027
TrEMBL
other Location (Reliability: 2 )
A0A2P6Q0G5_ROSCH
337
0
37114
TrEMBL
Mitochondrion (Reliability: 3 )
B2NI94_CARLC
33
0
3579
TrEMBL
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Q9SZB3_ARATH
344
0
37861
TrEMBL
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40630
1 * 40630, calculated from sequence
42800
1 * 42800, SDS-PAGE
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monomer
1 * 40630, calculated from sequence
monomer
1 * 42800, SDS-PAGE
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overexpression of recombinant Arabidopsis farnesol dehydrogenase activity in Saccharomyces cerevisiae strain SM1058 using pCL196 plasmid
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expression is increased in mutants with T-DNA insertions in the FLDH 5' flanking region indicating that both T-DNA insertions disrupt a cis-acting negative regulatory element in the FLDH promoter
FLDH expression is repressed by exogenous abscisic acid and FLDH expression negatively regulates ABA signaling
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Noge, K.; Kato, M.; Mori, N.; Kataoka, M.; Tanaka, C.; Yamasue, Y.; Nishida, R.; Kuwahara, Y.
Geraniol dehydrogenase, the key enzyme in biosynthesis of the alarm pheromone, from the astigmatid mite Carpoglyphus lactis (Acari: Carpoglyphidae)
FEBS J.
275
2807-2817
2008
Carpoglyphus lactis (B2NI94)
brenda
Bhandari, J.; Fitzpatrick, A.H.; Crowell, D.N.
Identification of a novel abscisic acid-regulated farnesol dehydrogenase from Arabidopsis thaliana
Plant Physiol.
154
1116-1127
2010
Arabidopsis thaliana (Q9SZB3)
brenda
Baker, F.C.; MAuchamp, B.; Tsai, L.W.; Schooley, D.A.
Farnesol and farnesal dehydrogenase(s) in corpora allata of the tobacco hornworm moth, Manduca sexta
J. Lipid Res.
24
1586-1594
1983
Manduca sexta
brenda
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1.1.1.354 farnesol dehydrogenase (NAD+)
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