We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Information on EC 1.1.1.354 - farnesol dehydrogenase (NAD+) for references in articles please use BRENDA:EC1.1.1.354
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments The enzyme from the prune mite Carpoglyphus lactis also acts on geraniol with greater activity [cf. EC 1.1.1.347, geraniol dehydrogenase (NAD+)]. Unlike EC 1.1.1.216, farnesol dehydrogenase (NADP+), this enzyme cannot use NADP+ as cofactor.
Word Map
1.1.1.354
sirtuins
nad+-dependent
deacetylation
desuccinylation
desuccinylase
deacetylases
nicotinamide
deacylase
carbamoyl
demalonylase
malonylation
glutarylation
The enzyme appears in viruses and cellular organisms
Synonyms
farnesol dehydrogenase, GeDH, NAD+-farnesol dehydrogenase,
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NAD+-farnesol dehydrogenase
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2E,6E)-farnesol + NAD+ = (2E,6E)-farnesal + NADH + H+
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2E,6E)-farnesol:NAD+ 1-oxidoreductase
The enzyme from the prune mite Carpoglyphus lactis also acts on geraniol with greater activity [cf. EC 1.1.1.347, geraniol dehydrogenase (NAD+)]. Unlike EC 1.1.1.216, farnesol dehydrogenase (NADP+), this enzyme cannot use NADP+ as cofactor.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2E,6E)-farnesol + NAD+
(2E,6E)-farnesal + NADH + H+
3-methyl-2-buten-1-ol + NAD+
3-methyl-2-butenal + NADH + H+
4.3% of the activity compared to geraniol
-
-
?
citronellol + NAD+
?
4.3% of the activity compared to geraniol
-
-
?
geraniol + NAD+
geranial + NADH + H+
geranylgeraniol + NAD+
? + NADH + H+
-
-
-
?
additional information
?
-
straight-chain alcohols such as 1-octanol, 2-buten-1-ol, 1-butanol and ethanol serve as poor substrates
-
-
-
(2E,6E)-farnesol + NAD+
(2E,6E)-farnesal + NADH + H+
highest affinity for the active site of the FLDH enzyme, FLDH-encoded enzyme does not exhibit appreciable farnesal reductase activity
-
-
ir
(2E,6E)-farnesol + NAD+
(2E,6E)-farnesal + NADH + H+
key enzyme in biosynthesis of the alarm pheromone neral
-
-
?
(2E,6E)-farnesol + NAD+
(2E,6E)-farnesal + NADH + H+
50% of the activity compared to geraniol
-
-
?
(2E,6E)-farnesol + NAD+
(2E,6E)-farnesal + NADH + H+
-
-
-
-
?
geraniol + NAD+
geranial + NADH + H+
-
-
-
?
geraniol + NAD+
geranial + NADH + H+
nerol, the geometrical isomer of geraniol is inactive. The enzyme cannot use NADP+ as cofactor
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2E,6E)-farnesol + NAD+
(2E,6E)-farnesal + NADH + H+
(2E,6E)-farnesol + NAD+
(2E,6E)-farnesal + NADH + H+
B2NI94
key enzyme in biosynthesis of the alarm pheromone neral
-
-
?
(2E,6E)-farnesol + NAD+
(2E,6E)-farnesal + NADH + H+
-
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NAD+
the enzyme cannot use NADP+ as cofactor
NAD+
no oxidation observed in the presence of NADP+
NAD+
-
dependent on NAD+, cannot be replaced by NADP+
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.051
geraniol
pH 8.5, 22°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2996
geraniol
pH 8.5, 22°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
58400
geraniol
pH 8.5, 22°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
8 - 10.5
pH 8.0: about 75% of maximal activity, pH 10.5: about 35% of maximal activity
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
5 - 60
5°C: about 50% of maximal activity, 60°C: about 50% of maximal activity
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
UniProt
brenda
-
UniProt
brenda
-
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
brenda
-
-
brenda
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
physiological function
key enzyme in biosynthesis of the alarm pheromone neral
physiological function
results suggest that FLDH is a negative regulator of ABA signaling
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
GEDH_CARLC
378
0
40630
Swiss-Prot
A0A2P6Q0F4_ROSCH
338
0
37201
TrEMBL
A0A2P6Q5A9_ROSCH
78
0
9027
TrEMBL
G7J6B7_MEDTR
333
0
36558
TrEMBL
A0A2P6QV66_ROSCH
55
0
6369
TrEMBL
Q9SZB3_ARATH
344
0
37861
TrEMBL
B2NI94_CARLC
33
0
3579
TrEMBL
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
40630
1 * 40630, calculated from sequence
42800
1 * 42800, SDS-PAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
monomer
1 * 40630, calculated from sequence; 1 * 42800, SDS-PAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
overexpression of recombinant Arabidopsis farnesol dehydrogenase activity in Saccharomyces cerevisiae strain SM1058 using pCL196 plasmid
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
expression is increased in mutants with T-DNA insertions in the FLDH 5' flanking region indicating that both T-DNA insertions disrupt a cis-acting negative regulatory element in the FLDH promoter
FLDH expression is repressed by exogenous abscisic acid and FLDH expression negatively regulates ABA signaling
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Noge, K.; Kato, M.; Mori, N.; Kataoka, M.; Tanaka, C.; Yamasue, Y.; Nishida, R.; Kuwahara, Y.
Geraniol dehydrogenase, the key enzyme in biosynthesis of the alarm pheromone, from the astigmatid mite Carpoglyphus lactis (Acari: Carpoglyphidae)
FEBS J.
275
2807-2817
2008
Carpoglyphus lactis (B2NI94)
brenda
Bhandari, J.; Fitzpatrick, A.H.; Crowell, D.N.
Identification of a novel abscisic acid-regulated farnesol dehydrogenase from Arabidopsis thaliana
Plant Physiol.
154
1116-1127
2010
Arabidopsis thaliana (Q9SZB3)
brenda
Baker, F.C.; MAuchamp, B.; Tsai, L.W.; Schooley, D.A.
Farnesol and farnesal dehydrogenase(s) in corpora allata of the tobacco hornworm moth, Manduca sexta
J. Lipid Res.
24
1586-1594
1983
Manduca sexta
brenda
Select items on the left to see more content.
html completed
HOME
login
history
all enzymes
BRENDA home
History
1.1.1.354 farnesol dehydrogenase (NAD+)
more
top
Information
