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Information on EC 1.1.1.351 - phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]

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IUBMB Comments
The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce reducing power and pentose for biosynthetic reactions. Unlike EC 1.1.1.44, phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating), it is not specific for NADP+ and can accept both cofactors with similar efficiency. cf. EC 1.1.1.343, phosphogluconate dehydrogenase [NAD+-dependent, decarboxylating].
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The enzyme appears in viruses and cellular organisms
Synonyms
6-phospho-d-gluconate dehydrogenase (decarboxylating), more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
6-phospho-D-gluconate + NAD(P)+ = D-ribulose 5-phosphate + CO2 + NAD(P)H + H+
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PATHWAY SOURCE
PATHWAYS
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