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Information on EC 1.1.1.345 - D-2-hydroxyacid dehydrogenase (NAD+)

for references in articles please use BRENDA:EC1.1.1.345

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IUBMB Comments

The enzymes, characterized from bacteria (Peptoclostridium difficile, Enterococcus faecalis and from lactic acid bacteria) prefer substrates with a main chain of 5 carbons (such as 4-methyl-2-oxopentanoate) to those with a shorter chain. It also utilizes phenylpyruvate. The enzyme from the halophilic archaeon Haloferax mediterranei prefers substrates with a main chain of 3-4 carbons (pyruvate and 2-oxobutanoate). cf. EC 1.1.1.272, (D)-2-hydroxyacid dehydrogenase (NADP+).

The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

Synonyms
d-mandelate dehydrogenase, d-2-hydroxyisocaproate dehydrogenase, d-isomer-specific 2-hydroxyacid dehydrogenase, d-hicdh, mandh2, d-mdh, nad-dependent d-2-hydroxyacid dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an (R)-2-hydroxycarboxylate + NAD+ = a 2-oxocarboxylate + NADH + H+
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
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