We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments Isolated from the bacterium Streptomyces avermitilis and present in many other Streptomyces species. Part of the pathway for pentalenolactone biosynthesis.
The enzyme appears in viruses and cellular organisms
Synonyms
1-deoxy-11beta-hydroxypentalenic acid dehydrogenase,
penF ,
ptlF , SAV_2933,
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1-deoxy-11beta-hydroxypentalenic acid dehydrogenase
-
-
-
ptlF
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1-deoxy-11beta-hydroxypentalenate + NAD+ = 1-deoxy-11-oxopentalenate + NADH + H+
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1-deoxy-11beta-hydroxypentalenate:NAD+ oxidoreductase
Isolated from the bacterium Streptomyces avermitilis and present in many other Streptomyces species. Part of the pathway for pentalenolactone biosynthesis.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1-deoxy-11beta-hydroxypentalenic acid + NAD+
1-deoxy-11-oxopentalenic acid + NADH + H+
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NAD+
150fold preference for NAD+ over NADP+
NADP+
150fold preference for NAD+ over NADP+
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.0065
1-deoxy-11beta-hydroxypentalenic acid
pH 8.0, 22°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.65
1-deoxy-11beta-hydroxypentalenic acid
pH 8.0, 22°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
11.3
activity increases from pH 9.0 to pH 11.3, and is 12fold higher at pH 11.3 than at pH 8.0
8
and second maximum at pH 11.3
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
UniProt
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
30183
x * 30183, MALDI-TOF, recombinant protein including His-tag
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
?
x * 30183, MALDI-TOF, recombinant protein including His-tag
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
expression in Escherichia coli
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
You, Z.; Omura, S.; Ikeda, H.; Cane, D.E.
Pentalenolactone biosynthesis: Molecular cloning and assignment of biochemical function to PtlF, a short-chain dehydrogenase from Streptomyces avermitilis, and identification of a new biosynthetic intermediate
Arch. Biochem. Biophys.
459
233-240
2007
Streptomyces avermitilis (Q82IY9)
brenda
Select items on the left to see more content.
html completed
HOME
login
history
all enzymes
BRENDA home
History
Enzyme Nomenclature
1.1.1.340 1-deoxy-11beta-hydroxypentalenate dehydrogenase
top
Information
