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Information on EC 1.1.1.340 - 1-deoxy-11beta-hydroxypentalenate dehydrogenase for references in articles please use BRENDA:EC1.1.1.340
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EC Tree
IUBMB Comments Isolated from the bacterium Streptomyces avermitilis and present in many other Streptomyces species. Part of the pathway for pentalenolactone biosynthesis.
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
1-deoxy-11beta-hydroxypentalenic acid dehydrogenase,
penF ,
ptlF , SAV_2933,
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1-deoxy-11beta-hydroxypentalenic acid dehydrogenase
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ptlF
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1-deoxy-11beta-hydroxypentalenate + NAD+ = 1-deoxy-11-oxopentalenate + NADH + H+
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1-deoxy-11beta-hydroxypentalenate:NAD+ oxidoreductase
Isolated from the bacterium Streptomyces avermitilis and present in many other Streptomyces species. Part of the pathway for pentalenolactone biosynthesis.
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1-deoxy-11beta-hydroxypentalenic acid + NAD+
1-deoxy-11-oxopentalenic acid + NADH + H+
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NAD+
150fold preference for NAD+ over NADP+
NADP+
150fold preference for NAD+ over NADP+
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0.0065
1-deoxy-11beta-hydroxypentalenic acid
pH 8.0, 22°C
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0.65
1-deoxy-11beta-hydroxypentalenic acid
pH 8.0, 22°C
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11.3
activity increases from pH 9.0 to pH 11.3, and is 12fold higher at pH 11.3 than at pH 8.0
8
and second maximum at pH 11.3
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UniProt
brenda
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30183
x * 30183, MALDI-TOF, recombinant protein including His-tag
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x * 30183, MALDI-TOF, recombinant protein including His-tag
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expression in Escherichia coli
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You, Z.; Omura, S.; Ikeda, H.; Cane, D.E.
Pentalenolactone biosynthesis: Molecular cloning and assignment of biochemical function to PtlF, a short-chain dehydrogenase from Streptomyces avermitilis, and identification of a new biosynthetic intermediate
Arch. Biochem. Biophys.
459
233-240
2007
Streptomyces avermitilis (Q82IY9)
brenda
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Enzyme Nomenclature
1.1.1.340 1-deoxy-11beta-hydroxypentalenate dehydrogenase
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