The enzyme is inactivated by EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} and reactivated by EC 3.1.3.47 {[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase}.
hmg-coa reductase, hmgcr, 3-hydroxy-3-methylglutaryl coenzyme a reductase, hmgr, hmg coa reductase, 3-hydroxy-3-methylglutaryl-coa reductase, 3-hydroxy-3-methylglutaryl-coenzyme a reductase, hmgcoa reductase, 3-hydroxy-3-methylglutaryl coa reductase, hmg-coar, more
The enzyme is inactivated by EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} and reactivated by EC 3.1.3.47 {[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase}.
rate-limiting enzyme for cholesterol synthesis, regulated via a negative feedback mechanism through sterols and non-sterol metabolites derived from mevalonate
identification of a cAMP-and cGMP-dependent protein kinase phosphorylation site, thirteen Protein kinase C phosphorylation sites, and eleven Casein kinase II phosphorylation sites
identification of five single nucleotide polymorphisms, three of them are synonymous mutations and the other two are missense mutations, the naturally occuring mutation T1541C causes a deletion of a CdxA element and a C/EBP binding site and created a c-Ets-binding site, and naturally occuring mutation G973T in exon 9, which is a synonymous mutation
identification of five single nucleotide polymorphisms, three of them are synonymous mutations and the other two are missense mutations, the naturally occuring mutation T1541C causes a deletion of a CdxA element and a C/EBP binding site and created a c-Ets-binding site, and naturally occuring mutation G973T in exon 9, which is a synonymous mutation