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Information on EC 1.1.1.337 - L-2-hydroxycarboxylate dehydrogenase (NAD+)

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IUBMB Comments
The enzyme from the archaeon Methanocaldococcus jannaschii acts on multiple (S)-2-hydroxycarboxylates including (2R)-3-sulfolactate, (S)-malate, (S)-lactate, and (S)-2-hydroxyglutarate . Note that (2R)-3-sulfolactate has the same stereo configuration as (2S)-2-hydroxycarboxylates.
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The expected taxonomic range for this enzyme is: Archaea, Bacteria
Synonyms
l-hicdh, l-2-hydroxyisocaproate dehydrogenase, sulfolactate dehydrogenase, mj1425, mdh i, l-hydroxyisocaproate dehydrogenase, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
a (2S)-2-hydroxycarboxylate + NAD+ = a 2-oxocarboxylate + NADH + H+
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