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Information on EC 1.1.1.334 - methylecgonone reductase

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IUBMB Comments
The enzyme from the plant Erythroxylum coca catalyses the penultimate step in the biosynthesis of cocaine. In vivo the reaction proceeds in the opposite direction. With NADH instead of NADPH the reaction rate is reduced to 14%. The enzyme also reduces tropinone, nortropinone and 6-hydroxytropinone but with lower reaction rates.
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The expected taxonomic range for this enzyme is: Erythroxylum coca
Synonyms
MecgoR, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ecgonine methyl ester + NADP+ = ecgonone methyl ester + NADPH + H+
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PATHWAY SOURCE
PATHWAYS
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