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Information on EC 1.1.1.330 - very-long-chain 3-oxoacyl-CoA reductase

for references in articles please use BRENDA:EC1.1.1.330

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IUBMB Comments

The second component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. The enzyme is active with substrates with chain length of C16 to C34, depending on the species. cf. EC 2.3.1.199, very-long-chain 3-oxoacyl-CoA synthase, EC 4.2.1.134, very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase, and EC 1.3.1.93, very-long-chain enoyl-CoA reductase.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

Synonyms
ybr159w, ifa38, very-long-chain 3-oxoacyl-coa reductase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP+ = a very-long-chain 3-oxoacyl-CoA + NADPH + H+
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
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