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Information on EC 1.1.1.324 - 8-hydroxygeraniol dehydrogenase

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IUBMB Comments
Contains Zn2+. The enzyme catalyses the oxidation of (6E)-8-hydroxygeraniol to (6E)-8-oxogeranial via either (6E)-8-hydroxygeranial or (6E)-8-oxogeraniol. Also acts on geraniol, nerol and citronellol. May be identical to EC 1.1.1.183 geraniol dehydrogenase. The recommended numbering of geraniol gives 8-hydroxygeraniol as the substrate rather than 10-hydroxygeraniol as used by references 1 and 2. See prenol nomenclature {iupac/misc/prenol#p1::Pr-1}.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
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Synonyms
8-hydroxygeraniol oxidoreductase, acyclic monoterpene primary alcohol:NADP+ oxidoreductase, CrG10H, CYP76B10, G10H, SmG10H, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(6E)-8-hydroxygeranial + NADP+ = (6E)-8-oxogeranial + NADPH + H+
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1c
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(6E)-8-hydroxygeraniol + 2 NADP+ = (6E)-8-oxogeranial + 2 NADPH + 2 H+
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overall reaction
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(6E)-8-hydroxygeraniol + NADP+ = (6E)-8-hydroxygeranial + NADPH + H+
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1a
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(6E)-8-hydroxygeraniol + NADP+ = (6E)-8-oxogeraniol + NADPH + H+
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1b
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(6E)-8-oxogeraniol + NADP+ = (6E)-8-oxogeranial + NADPH + H+
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1d
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