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Information on EC 1.1.1.286 - isocitrate-homoisocitrate dehydrogenase

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IUBMB Comments
Requires Mn2+ and K+ or NH4+ for activity. Unlike EC 1.1.1.41, isocitrate dehydrogenase (NAD+) and EC 1.1.1.87, homoisocitrate dehydrogenase, this enzyme, from Pyrococcus horikoshii, can use both isocitrate and homoisocitrate as substrates. The enzyme may play a role in both the lysine and glutamate biosynthesis pathways.
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The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
tk0280, saci_2375, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+
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isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH
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