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Information on EC 1.1.1.281 - GDP-4-dehydro-6-deoxy-D-mannose reductase

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IUBMB Comments
This enzyme differs from EC 1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-alpha-D-rhamnose. D-Rhamnose is a constituent of lipopolysaccharides of Gram-negative plant and human pathogenic bacteria.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
GDP-4-keto-6-deoxy-D-mannose reductase, GDP-4-keto-6-deoxy-D-mannose reductase (ambiguous), GDP-6-deoxy-D-lyxo-4-hexulose reductase, GDP-6-deoxy-D-mannose reductase, RMD, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
GDP-alpha-D-rhamnose + NAD(P)+ = GDP-4-dehydro-alpha-D-rhamnose + NAD(P)H + H+
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; This enzyme differs from EC 1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-D-rhamnose (GDP-6-deoxy-D-mannose). D-Rhamnose is a constituent of lipopolysaccharides of Gram-negative plant and human pathogenic bacteria
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