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Information on EC 1.1.1.266 - dTDP-4-dehydro-6-deoxyglucose reductase

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IUBMB Comments
The enzymes from the Gram-negative bacteria Aggregatibacter actinomycetemcomitans and Escherichia coli O52 are involved in activation of fucose for incorporation into capsular polysaccharide O-antigens [1,3]. The enzyme from the Gram-positive bacterium Anoxybacillus tepidamans (Geobacillus tepidamans) is involved in activation of fucose for incorporation into the organism's S-layer . The enzyme from Escherichia coli O52 has a higher catalytic efficiency with NADH than with NADPH .
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The enzyme appears in viruses and cellular organisms
Synonyms
dtdp-4-keto-6-deoxyglucose reductase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
dTDP-alpha-D-fucopyranose + NAD(P)+ = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + NAD(P)H + H+
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The enzyme from the gram-negative bacterium Actinobacillus actinomycetemcomitans forms activated fucose for incorporation into capsular polysaccharide
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