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Synonyms
yol151w, gre2p, ymr152wp, ymr152w, 3-methylbutanal reductase, isovaleraldehyde reductase, branched-chain alcohol dehydrogenase, gre2 gene product,
more
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2,3-pentanedione + NAD(P)H
? + NAD(P)+
-
very low activity
-
?
2-methylbutanal + NAD(P)H
2-methylbutanol + NAD(P)+
-
-
-
r
3-methylbutanal + NAD(P)H
3-methylbutanol + NAD(P)+
3-methylbutanal + NAD(P)H + H+
3-methylbutanol + NAD(P)+
-
-
-
r
3-methylbutanal + NADH + H+
3-methylbutanol + NAD+
-
-
-
-
r
3-methylbutanal + NADPH + H+
3-methylbutanol + NADP+
3-methylthiopropionaldehyde + NADPH + H+
3-methylthiopropanol + NADP+
-
specific substrate for Sacchaormyces cerevisiae, main contribution to the strong worty flavor of alcohol-free beer
-
?
3-pyridine carboxaldehyde + NAD(P)H
3-pyridinemethanol + NAD(P)+
-
highest activity
-
?
5-hydroxymethylfurfural + NADH + H+
2,5-dihydroxymethylfurane + NAD+
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
acetaldehyde + NADPH + H+
ethanol + NADP+
benzaldehyde + NAD(P)H
benzyl alcohol + NAD(P)+
benzaldehyde + NADPH + H+
benzylalcohol + NADP+
butanal + NAD(P)H + H+
butanol + NAD(P)+
-
-
-
r
diacetyl + NAD(P)H
? + NAD(P)+
furaldehyde + NAD(P)H
furfuryl alcohol + NAD(P)+
furfural + NADH + H+
furfuryl alcohol + NAD+
gluconate + NAD(P)H
D-glucose + NAD(P)+
-
very low activity in both reduction and oxidation
-
r
glyceraldehyde + NAD(P)H
glycerol + NAD(P)+
-
-
-
?
glycolaldehyde + NADH + H+
ethylene glycol + NAD+
-
-
-
r
heptanal + NADPH
heptanol + NADP+
-
preference for long and branched-chain substrates with up to seven carbon atoms
-
r
hexanal + NADPH + H+
hexanol + NADP+
isovaleraldehyde + NADPH + H+
isoamyl alcohol + NADP+
-
important role in the suppression of filamentation in response to isoamyl alcohol/isovaleraldehyde
-
-
r
methyl glyoxal + NAD(P)H
? + NAD(P)+
-
low activity
-
?
octanal + NAD(P)H + H+
octanol + NAD(P)+
-
-
-
?
p-anisaldehyde + NAD(P)H
p-anisalcohol + NAD(P)+
-
20-50% of the activity with 3-methylbutanal for aromatic aldehydes
-
?
pentanal + NADPH
pentanol + NADP+
propanal + NAD(P)H + H+
propanol + NAD(P)+
-
-
-
r
trans-2-hexenol + NADP+
trans-2-hexenal + NADPH
-
-
-
?
additional information
?
-
3-methylbutanal + NAD(P)H

3-methylbutanol + NAD(P)+
-
-
-
r
3-methylbutanal + NAD(P)H
3-methylbutanol + NAD(P)+
-
-
-
r
3-methylbutanal + NAD(P)H
3-methylbutanol + NAD(P)+
-
-
-
r
3-methylbutanal + NAD(P)H
3-methylbutanol + NAD(P)+
-
-
-
r
3-methylbutanal + NAD(P)H
3-methylbutanol + NAD(P)+
-
-
-
r
3-methylbutanal + NAD(P)H
3-methylbutanol + NAD(P)+
-
-
-
r
3-methylbutanal + NADPH + H+

3-methylbutanol + NADP+
-
-
-
r
3-methylbutanal + NADPH + H+
3-methylbutanol + NADP+
low activity
-
-
r
acetaldehyde + NADH + H+

ethanol + NAD+
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
best substrate
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
best substrate
-
-
r
acetaldehyde + NADPH + H+

ethanol + NADP+
-
-
-
r
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
r
benzaldehyde + NAD(P)H

benzyl alcohol + NAD(P)+
-
high activity
-
?
benzaldehyde + NAD(P)H
benzyl alcohol + NAD(P)+
-
20-50% of the activity with 3-methylbutanal for aromatic aldehydes
-
?
benzaldehyde + NADPH + H+

benzylalcohol + NADP+
-
-
-
r
benzaldehyde + NADPH + H+
benzylalcohol + NADP+
low activity
-
-
r
benzaldehyde + NADPH + H+
benzylalcohol + NADP+
-
-
-
r
diacetyl + NAD(P)H

? + NAD(P)+
-
very low activity
-
?
diacetyl + NAD(P)H
? + NAD(P)+
-
very low activity
-
?
furaldehyde + NAD(P)H

furfuryl alcohol + NAD(P)+
-
-
-
?
furaldehyde + NAD(P)H
furfuryl alcohol + NAD(P)+
-
20-50% of the activity with 3-methylbutanal for aromatic aldehydes
-
?
furfural + NADH + H+

furfuryl alcohol + NAD+
-
-
-
r
furfural + NADH + H+
furfuryl alcohol + NAD+
-
-
-
r
hexanal + NADPH + H+

hexanol + NADP+
-
-
-
-
r
hexanal + NADPH + H+
hexanol + NADP+
-
-
-
r
pentanal + NADPH

pentanol + NADP+
-
-
-
r
pentanal + NADPH
pentanol + NADP+
-
-
-
r
additional information

?
-
-
enzyme displays also NADPH dependent methylglyoxal reductase activity (EC 1.1.1.283)
-
-
?
additional information
?
-
Ymr152wp catalyzes reactions for reduction of acetaldehyde, glycolaldehyde, furfural, and 5-hydroxymethylfurfural (HMF) when NADH is used as the cofactor. Besides, enzyme activity is detected for reduction of benzaldehyde (BZA) and 3-methylbutanal (MBA) when NADPH is used as the cofactor. Ymr152wp shows the highest specific enzyme activity (190.86 U/mg) for reduction of acetaldehyde, followed by glycolaldehyde (9.64 U/mg), furfural (5.05 U/mg), HMF (1.74 U/mg), BZA (1.12 U/mg), and MBA (0.74 U/mg). No activity with formaldehyde, propionaldehyde, butyraldehyde, glutaraldehyde, quinone, 1,2-naphthoquinone, 9,10-phenanthrenequinone, 4-benzoquinone, acetone, and acetylacetone, neither with NADH, nor with NADPH
-
-
-
additional information
?
-
-
Ymr152wp catalyzes reactions for reduction of acetaldehyde, glycolaldehyde, furfural, and 5-hydroxymethylfurfural (HMF) when NADH is used as the cofactor. Besides, enzyme activity is detected for reduction of benzaldehyde (BZA) and 3-methylbutanal (MBA) when NADPH is used as the cofactor. Ymr152wp shows the highest specific enzyme activity (190.86 U/mg) for reduction of acetaldehyde, followed by glycolaldehyde (9.64 U/mg), furfural (5.05 U/mg), HMF (1.74 U/mg), BZA (1.12 U/mg), and MBA (0.74 U/mg). No activity with formaldehyde, propionaldehyde, butyraldehyde, glutaraldehyde, quinone, 1,2-naphthoquinone, 9,10-phenanthrenequinone, 4-benzoquinone, acetone, and acetylacetone, neither with NADH, nor with NADPH
-
-
-
additional information
?
-
Ymr152wp catalyzes reactions for reduction of acetaldehyde, glycolaldehyde, furfural, and 5-hydroxymethylfurfural (HMF) when NADH is used as the cofactor. Besides, enzyme activity is detected for reduction of benzaldehyde (BZA) and 3-methylbutanal (MBA) when NADPH is used as the cofactor. Ymr152wp shows the highest specific enzyme activity (190.86 U/mg) for reduction of acetaldehyde, followed by glycolaldehyde (9.64 U/mg), furfural (5.05 U/mg), HMF (1.74 U/mg), BZA (1.12 U/mg), and MBA (0.74 U/mg). No activity with formaldehyde, propionaldehyde, butyraldehyde, glutaraldehyde, quinone, 1,2-naphthoquinone, 9,10-phenanthrenequinone, 4-benzoquinone, acetone, and acetylacetone, neither with NADH, nor with NADPH
-
-
-
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3-methylbutanal + NAD(P)H
3-methylbutanol + NAD(P)+
3-methylbutanal + NADPH + H+
3-methylbutanol + NADP+
-
-
-
r
5-hydroxymethylfurfural + NADH + H+
2,5-dihydroxymethylfurane + NAD+
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
acetaldehyde + NADPH + H+
ethanol + NADP+
benzaldehyde + NADPH + H+
benzylalcohol + NADP+
furfural + NADH + H+
furfuryl alcohol + NAD+
gluconate + NAD(P)H
D-glucose + NAD(P)+
-
very low activity in both reduction and oxidation
-
r
glyceraldehyde + NAD(P)H
glycerol + NAD(P)+
-
-
-
?
glycolaldehyde + NADH + H+
ethylene glycol + NAD+
-
-
-
r
isovaleraldehyde + NADPH + H+
isoamyl alcohol + NADP+
-
important role in the suppression of filamentation in response to isoamyl alcohol/isovaleraldehyde
-
-
r
3-methylbutanal + NAD(P)H

3-methylbutanol + NAD(P)+
-
-
-
r
3-methylbutanal + NAD(P)H
3-methylbutanol + NAD(P)+
-
-
-
r
3-methylbutanal + NAD(P)H
3-methylbutanol + NAD(P)+
-
-
-
r
3-methylbutanal + NAD(P)H
3-methylbutanol + NAD(P)+
-
-
-
r
3-methylbutanal + NAD(P)H
3-methylbutanol + NAD(P)+
-
-
-
r
3-methylbutanal + NAD(P)H
3-methylbutanol + NAD(P)+
-
-
-
r
acetaldehyde + NADH + H+

ethanol + NAD+
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
-
-
-
r
acetaldehyde + NADPH + H+

ethanol + NADP+
-
-
-
r
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
r
benzaldehyde + NADPH + H+

benzylalcohol + NADP+
-
-
-
r
benzaldehyde + NADPH + H+
benzylalcohol + NADP+
-
-
-
r
furfural + NADH + H+

furfuryl alcohol + NAD+
-
-
-
r
furfural + NADH + H+
furfuryl alcohol + NAD+
-
-
-
r
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2-methylbutanal
-
presence of NADPH, Ki: 2.74 mM, presence of NADH, Ki: 4.61 mM
3-Methylbutanal
-
presence of NADPH, Ki: 7.14 mM, presence of NADH, Ki: 253 mM
Butanal
-
presence of NADPH, Ki: 16.6 mM
dithiothreitol
-
35% inhibition at 5 mM
glutathione
-
24% inhibition at 5 mM
Heptanal
-
presence of NADPH, Ki: 0.88 mM, presence of NADH, Ki: 1.17 mM
hexanal
-
presence of NADPH, Ki: 0.79 mM, presence of NADH, Ki: 2.8 mM
NADP+
-
complete inhibition at a 6.7fold excess of NADP+ in a reduction assay with 0.15 mM NADH
pentanal
-
presence of NADPH, Ki: 3.9 mM, presence of NADH, Ki: 13.9 mM
propanal
-
presence of NADPH, Ki: 46.6 mM
quercetin
-
78% inhibition at 0.1 mM
sodium valporate
-
5% inhibition at 1 mM
2-mercaptoethanol

-
6% inhibition at 10 mM
2-mercaptoethanol
inhibition level depends on the substrate used, about 40% inhibition at 10 mM
Ca2+

-
9% inhibition at 0.1 mM
Ca2+
slight inhibition at 2 mM, slight activation at 0.5 mM, dependent on the substrate
KCl

-
16% inhibition at 0.2 M
KCl
-
5-6fold decreasing activity at 0.2 M for NADH-dependent activity
Mg2+

-
6% inhibition at 0.1 mM
Mg2+
slight inhibition at 2 mM, slight activation at 0.5 mM, dependent on the substrate
NaCl

-
19% inhibition at 0.2 M
NaCl
-
5-6fold decreasing activity at 0.2 M for NADH-dependent activity
Zn2+

-
28% inhibition at 0.1 mM
additional information

the strength of inhibition by metal ions depends on the substrate used, overview
-
additional information
-
the strength of inhibition by metal ions depends on the substrate used, overview
-
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