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Enzyme Nomenclature
Information on EC 1.1.1.260 - sulcatone reductase
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
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EC NUMBER 
COMMENTARY 
1.1.1.260
-
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RECOMMENDED NAME
GeneOntology No.
sulcatone reductase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
sulcatol + NAD+ = sulcatone + NADH + H+
Studies on the effect of growth-state and nutrient supply on the stereochemistry of sulcatone reduction in Clostridia pasteurianum, C. tyrobutyricum and Lactobacillus brevis suggest that there may at least two sulcatone reductases with different stereospecificities
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-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
sulcatol:NAD+ oxidoreductase
Studies on the effects of growth-stage and nutrient supply on the stereochemistry of sulcatone reduction in Clostridia pasteurianum, C. tyrobutyricum and Lactobacillus brevis suggest that there may be at least two sulcatone reductases with different stereospecificities.
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CAS REGISTRY NUMBER
COMMENTARY
196522-54-0
-
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
sulcatone
sulcatol, 80% sulcatol R(-) enantiomer after 24 h reaction time
r
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
enantiomeric selectivity substantially affected by pregrowth period and substrate concentration
sulcatol
r
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
sulcatone
sulcatol
r
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
sulcatone
sulcatol
r
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
sulcatone
sulcatol, 80% of sulcatol R enantiomer after 48 h reaction time
r
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
sulcatone
sulcatol
r
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
sulcatone
96% sulcatol R enantiomer after 17 h reaction time, sulcatol
r
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
sulcatone
only sensitive to S enantiomer, inhibited by the R enantiomer, sulcatol
r
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
sulcatone
sulcatol, mixture of 65% S(+)- and 35% S(-)-sulcatol isomers
r
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
sulcatone
sulcatol
r
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
R(-)-sulcatol in high enantiomeric excess formed irrespective of pregrowth period and substrate concentration
sulcatol
r
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
sulcatone
sulcatol, S enantiomer formed
r
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
sulcatone
100% enantiomeric excess for S(+)-sulcatol, sulcatol, S enantiomer formed
r
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
sulcatone
sulcatol, 80% sulcatol R(-) enantiomer after 24 h reaction time
r
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
enantiomeric selectivity substantially affected by pregrowth period and substrate concentration
sulcatol
r
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
sulcatone
sulcatol
r
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
sulcatone
sulcatol
r
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
sulcatone
sulcatol, 80% of sulcatol R enantiomer after 48 h reaction time
r
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
sulcatone
sulcatol
r
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
sulcatone
96% sulcatol R enantiomer after 17 h reaction time, sulcatol
r
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
sulcatone
only sensitive to S enantiomer, inhibited by the R enantiomer, sulcatol
r
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
sulcatone
sulcatol, mixture of 65% S(+)- and 35% S(-)-sulcatol isomers
r
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
sulcatone
sulcatol
r
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
R(-)-sulcatol in high enantiomeric excess formed irrespective of pregrowth period and substrate concentration
sulcatol
r
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
sulcatone
sulcatol, S enantiomer formed
r
6-methylhept-5-en-2-one + NADH
6-methylhept-5-en-2-ol + NAD+
-
sulcatone
100% enantiomeric excess for S(+)-sulcatol, sulcatol, S enantiomer formed
r
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
synthesis
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LINKS TO OTHER DATABASES (specific for EC-Number 1.1.1.260)
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