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Information on EC 1.1.1.236 - tropinone reductase II

for references in articles please use BRENDA:EC1.1.1.236

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IUBMB Comments

This enzyme along with EC 1.1.1.206, tropine dehydrogenase, represents a branch point in tropane alkaloid metabolism . Tropine (the product of EC 1.1.1.206) is incorporated into hyoscyamine and scopolamine whereas pseudotropine (the product of EC 1.1.1.236) is the first specific metabolite on the pathway to the calystegines . Both enzymes are always found together in any given tropane-alkaloid-producing species, have a common substrate, tropinone, and are strictly stereospecific .

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
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pseudotropine
+
NADP+
=
tropinone
+
NADPH
+
H+
+
=
+
+

Synonyms
tr-ii, tropinone reductase ii, dntr2, tropinone reductase-ii, pseudotropine-forming tropinone reductase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
pseudotropine + NADP+ = tropinone + NADPH + H+
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
calystegine biosynthesis