Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 1.1.1.234 - flavanone 4-reductase and Organism(s) Malus domestica and UniProt Accession Q9XES5

for references in articles please use BRENDA:EC1.1.1.234
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.234 flavanone 4-reductase
IUBMB Comments
Involved in the biosynthesis of 3-deoxyanthocyanidins from flavanones such as naringenin or eriodictyol.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Malus domestica
UNIPROT: Q9XES5
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Malus domestica
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
flavanone 4-reductase, sb06g029550 protein, sb06g029550, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2S)-flavan-4-ol + NADP+ = (2S)-flavanone + NADPH + H+
show the reaction diagram
enzyme acts as flavone 4-reductase as well as dihydroflavonol 4-reductase
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
-
oxidation
-
-
-
-
reduction
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -
SYSTEMATIC NAME
IUBMB Comments
(2S)-flavan-4-ol:NADP+ 4-oxidoreductase
Involved in the biosynthesis of 3-deoxyanthocyanidins from flavanones such as naringenin or eriodictyol.
CAS REGISTRY NUMBER
COMMENTARY hide
115232-53-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2S)-eriodictyol + NADPH
luteoforol + NADP+
show the reaction diagram
(2S)-flavanone + NADPH
(2S)-flavan-4-ol + NADP+
show the reaction diagram
(2S)-naringenin + NADPH + H+
apiforol + NADP+
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(2S)-eriodictyol + NADPH
luteoforol + NADP+
show the reaction diagram
reaction provides precursors for the synthesis of 3-deoxyanthocyanidins
reaction provides precursors for the synthesis of 3-deoxyanthocyanidins
-
?
(2S)-flavanone + NADPH
(2S)-flavan-4-ol + NADP+
show the reaction diagram
reaction provides precursors for the synthesis of 3-deoxyanthocyanidins
-
-
?
(2S)-naringenin + NADPH + H+
apiforol + NADP+
show the reaction diagram
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25
native enzyme
40
recombinant enzyme from yeast
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strains M9 and Weirouge
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DFRA_MALDO
348
0
39030
Swiss-Prot
other Location (Reliability: 3)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in yeast strain InvSc1
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Fischer, T.C.; Halbwirth, H.; Meisel, B.; Stich, K.; Forkmann, G.
Molecular cloning, substrate specificity of the functionally expressed dihydroflavonol 4-reductases from Malus domestica and Pyrus communis cultivars and the consequences for flavonoid metabolism
Arch. Biochem. Biophys.
412
223-230
2003
Malus domestica (Q9XES5), Malus domestica, Pyrus communis
Manually annotated by BRENDA team