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Enzyme Nomenclature
Information on EC 1.1.1.223 - isopiperitenol dehydrogenase
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The enzyme appears in viruses and cellular organisms
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EC NUMBER 
COMMENTARY 
1.1.1.223
-
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RECOMMENDED NAME
GeneOntology No.
isopiperitenol dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
(-)-trans-isopiperitenol + NAD+ = (-)-isopiperitenone + NADH + H+
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
redox reaction
-
-
-
-
reduction
-
-
-
-
oxidation
-
-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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SYSTEMATIC NAME
IUBMB Comments
(-)-trans-isopiperitenol:NAD+ oxidoreductase
Acts on (-)-trans-isopiperitenol, (+)-trans-piperitenol and (+)-trans-pulegol. Involved in the biosynthesis of menthol and related monoterpenes in peppermint (Mentha piperita) leaves.
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CAS REGISTRY NUMBER
COMMENTARY
96595-05-0
-
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
PK-type, not found in not found in PT-type strains nos. 5598 and 5601
UniProt
PK-type, not found in not found in PT-type strains nos. 5598 and 5601
UniProt
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
metabolism
physiological function
metabolism
the enzyme is involved in the biosynthetic pathways of oil constituents (PA-type, PT-type, and PK-type) in Perilla, putative pathways, overview; the enzyme is involved in the biosynthetic pathways of oil constituents (PA-type, PT-type, and PK-type) in Perilla, putative pathways, overview. (-)-cis-Isopiperitenol is an intermediate for the piperitenone biosynthesis of perilla
metabolism
the enzyme is involved in the biosynthetic pathways of oil constituents (PA-type, PT-type, and PK-type) in Perilla, putative pathways, overview. (-)-cis-Isopiperitenol is an intermediate for the piperitenone biosynthesis of perilla
metabolism
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the enzyme is involved in the biosynthetic pathways of oil constituents (PA-type, PT-type, and PK-type) in Perilla, putative pathways, overview; the enzyme is involved in the biosynthetic pathways of oil constituents (PA-type, PT-type, and PK-type) in Perilla, putative pathways, overview. (-)-cis-Isopiperitenol is an intermediate for the piperitenone biosynthesis of perilla
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metabolism
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the enzyme is involved in the biosynthetic pathways of oil constituents (PA-type, PT-type, and PK-type) in Perilla, putative pathways, overview. (-)-cis-Isopiperitenol is an intermediate for the piperitenone biosynthesis of perilla
-
physiological function
isozyme ISPD1 is less likely to be involved in oxidation of isopiperitenol; isozyme ISPD2 is likely to be involved in oxidation of isopiperitenol
physiological function
isozyme ISPD2 is likely to be involved in oxidation of isopiperitenol
physiological function
-
isozyme ISPD1 is less likely to be involved in oxidation of isopiperitenol; isozyme ISPD2 is likely to be involved in oxidation of isopiperitenol
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physiological function
-
isozyme ISPD2 is likely to be involved in oxidation of isopiperitenol
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(+)-isomenthol + NAD+
(+)-isomenthone + NADH
-
activity less than 2% of that of (-)-trans-isopiperitenol
-
-
?
(+)-trans-isopiperitenol + NAD+
(+)-isopiperitenone + NADH
-
95% activity of that of (-)-trans-isopiperitenol
-
?
(+)-trans-pulegol + NAD+
(R)-pulegone + NADH
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19% activity of that of (-)-trans-isopiperitenol
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-
?
(-)-cis-isopiperitenol + NAD+
(-)-isopiperitenone + NADH + H+
-
-
-
r
(-)-cis-isopiperitenol + NAD+
(-)-isopiperitenone + NADH + H+
-
-
-
ir
(-)-cis-isopiperitenol + NAD+
(-)-isopiperitenone + NADH + H+
-
-
-
ir
(-)-cis-isopiperitenol + NAD+
(-)-isopiperitenone + NADH + H+
-
-
-
r
(-)-cis-isopiperitenol + NAD+
(-)-isopiperitenone + NADH + H+
-
-
-
ir
(-)-cis-isopiperitenol + NAD+
(-)-isopiperitenone + NADH + H+
-
-
-
ir
(-)-trans-isopiperitenol + NAD+
(-)-isopiperitenone + NADH
-
preferred substrate, not readily reversible in pH range 6.5-10.5
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r
(-)-trans-isopiperitenol + NAD+
(-)-isopiperitenone + NADH
-
central enzyme in menthol biosynthesis pathway
-
r
(-)-trans-isopiperitenol + NAD+
(-)-isopiperitenone + NADH
-
central enzyme in menthol biosynthesis pathway
-
-
r
(-)-trans-isopiperitenol + NAD+
(-)-isopiperitenone + NADH + H+
-
-
-
r
(-)-trans-isopiperitenol + NAD+
(-)-isopiperitenone + NADH + H+
-
-
-
r
(-)-trans-isopiperitenol + NADP+
(-)-isopiperitenone + NADPH + H+
-
-
-
-
?
additional information
?
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ISPD1 has broader substrate specificity than ISPD2
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-
-
additional information
?
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ISPD1 has broader substrate specificity than ISPD2
-
-
-
additional information
?
-
ISPD2 has a greater substrate specificity compared to ISPD1
-
-
-
additional information
?
-
ISPD2 has a greater substrate specificity compared to ISPD1
-
-
-
additional information
?
-
ISPD2 has a greater substrate specificity compared to ISPD1
-
-
-
additional information
?
-
ISPD2 has a greater substrate specificity compared to ISPD1
-
-
-
additional information
?
-
ISPD1 has broader substrate specificity than ISPD2
-
-
-
additional information
?
-
ISPD1 has broader substrate specificity than ISPD2
-
-
-
additional information
?
-
ISPD2 has a greater substrate specificity compared to ISPD1
-
-
-
additional information
?
-
ISPD2 has a greater substrate specificity compared to ISPD1
-
-
-
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(-)-cis-isopiperitenol + NAD+
(-)-isopiperitenone + NADH + H+
W5VJM4, W5VJT8
-
-
-
r
(-)-cis-isopiperitenol + NAD+
(-)-isopiperitenone + NADH + H+
W5VJM4, W5VJT8
-
-
-
ir
(-)-cis-isopiperitenol + NAD+
(-)-isopiperitenone + NADH + H+
W5VJM4, W5VJT8
-
-
-
ir
(-)-cis-isopiperitenol + NAD+
(-)-isopiperitenone + NADH + H+
W5VJM4, W5VJT8
-
-
-
r
(-)-cis-isopiperitenol + NAD+
(-)-isopiperitenone + NADH + H+
W5VJJ6
-
-
-
ir
(-)-cis-isopiperitenol + NAD+
(-)-isopiperitenone + NADH + H+
W5VJJ6
-
-
-
ir
(-)-trans-isopiperitenol + NAD+
(-)-isopiperitenone + NADH
-
central enzyme in menthol biosynthesis pathway
-
r
(-)-trans-isopiperitenol + NAD+
(-)-isopiperitenone + NADH
-
central enzyme in menthol biosynthesis pathway
-
-
r
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
recombinant His-tagged enzyme from Escherichia coli strain TOP10F'
recombinant His-tagged enzyme from Escherichia coli strain TOP10F'; recombinant His-tagged enzyme from Escherichia coli strain TOP10F'
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
gene PK-ISPD1, DNA and amino acid sequence determination and analysis, sequence comparisons, recombinant expression of His-tagged enzyme in Escherichia coli strain TOP10F'; gene PT-ISPD2, DNA and amino acid sequence determination and analysis, sequence comparisons, recombinant expression of His-tagged enzyme in Escherichia coli strain TOP10F'
gene PT-ISPD2, DNA and amino acid sequence determination and analysis, sequence comparisons, recombinant expression of His-tagged enzyme in Escherichia coli strain TOP10F'
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LINKS TO OTHER DATABASES (specific for EC-Number 1.1.1.223)
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