Information on EC 1.1.1.21 - aldehyde reductase and Organism(s) Homo sapiens and UniProt Accession O60218

for references in articles please use BRENDA:EC1.1.1.21
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This record set is specific for:
Homo sapiens
UNIPROT: O60218


The expected taxonomic range for this enzyme is: Eukaryota, Bacteria


The taxonomic range for the selected organisms is: Homo sapiens

EC NUMBER
COMMENTARY hide
1.1.1.21
-
RECOMMENDED NAME
GeneOntology No.
aldehyde reductase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
alditol + NAD(P)+ = aldose + NAD(P)H + H+
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
D-galactose degradation IV
-
-
D-xylose degradation II
-
-
L-arabinose degradation II
-
-
lipid A biosynthesis
-
-
Pentose and glucuronate interconversions
-
-
Fructose and mannose metabolism
-
-
Galactose metabolism
-
-
Glycerolipid metabolism
-
-
Folate biosynthesis
-
-
Metabolic pathways
-
-
SYSTEMATIC NAME
IUBMB Comments
alditol:NAD(P)+ 1-oxidoreductase
Has wide specificity.
CAS REGISTRY NUMBER
COMMENTARY hide
9028-31-3
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
-
the enzyme AKR1B10 belongs to the AKR1B subfamily
physiological function
-
AKR1B10 is a tumor marker and displays high activity with the retinoic acid precursor all-trans-retinaldehyde and is induced in different types of cancer, notably in non-small cell lung and hepatocellular carcinomas
evolution
malfunction
metabolism
physiological function
additional information
-
inverse relationship between RUNX2 activity and AR expression, which is induced by hyperglycemia and supports a role for AR in the suppression of RUNX2 activity under hyperglycemic conditions
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-butanal + NADPH + H+
butanol + NADP+
show the reaction diagram
-
-
-
?
1-decanol + NADP+
decanal + NADPH + H+
show the reaction diagram
-
-
-
?
1-dodecanal + NADPH + H+
dodecanol + NADP+
show the reaction diagram
-
-
-
?
1-heptanal + NADPH + H+
heptanol + NADP+
show the reaction diagram
-
-
-
?
1-hexanal + NADPH + H+
hexanol + NADP+
show the reaction diagram
-
-
-
?
1-nonanal + NADPH + H+
nonanol + NADP+
show the reaction diagram
-
-
-
?
1-nonanol + NADP+
nonanal + NADPH + H+
show the reaction diagram
-
-
-
?
1-tetradecanol + NADP+
tetradecanal + NADPH + H+
show the reaction diagram
-
-
-
?
2,3-hexanedione + NADPH + H+
?
show the reaction diagram
-
-
-
?
20alpha-hydroxyprogesterone + NADPH + H+
?
show the reaction diagram
-
-
-
?
21-dehydrocortisol + NADPH + H+
?
show the reaction diagram
-
-
-
?
3-deoxyglucosone + NADPH + H+
?
show the reaction diagram
-
-
-
?
5-pregnene-3beta,20alpha-diol + NADPH
?
show the reaction diagram
-
-
-
?
5alpha-pregnan-20alpha-ol-3-one + NADPH + H+
?
show the reaction diagram
-
-
-
?
5alpha-pregnane-3beta,20alpha-diol + NADPH + H+
?
show the reaction diagram
-
-
-
?
benzaldehyde + NADPH + H+
benzyl alcohol + NADP+
show the reaction diagram
-
-
-
?
D-lactaldehyde + NADPH + H+
?
show the reaction diagram
-
-
-
?
DL-glyceraldehyde + NADPH + H+
glycerol + NADP+
show the reaction diagram
-
-
-
-
?
farnesal + NADPH + H+
trans,trans-farnesol + NADP+
show the reaction diagram
specific substrate
-
-
?
geraniol + NADP+
geranial + NADPH + H+
show the reaction diagram
-
-
-
?
geranylgeranial + NADPH + H+
geranylgeraniol + NADP+
show the reaction diagram
specific substrate
-
-
?
glycolaldehyde + NADPH + H+
?
show the reaction diagram
-
-
-
?
glyoxal + NADPH + H+
?
show the reaction diagram
-
-
-
?
isatin + NADPH + H+
3-hydroxyisatin + NADP+
show the reaction diagram
specific substrate
-
-
?
isocaproaldehyde + NADPH + H+
?
show the reaction diagram
-
-
-
?
nerol + NADPH + H+
?
show the reaction diagram
-
-
-
?
octanal + NADPH + H+
octanol + NADP+
show the reaction diagram
-
-
-
?
pyridine-3-aldehyde + NADPH + H+
3-hydroxypyridine + NADP+
show the reaction diagram
-
-
-
?
pyridine-3-methanol + NADP+
?
show the reaction diagram
-
-
-
?
trans-2-buten-1-al + NADPH + H+
?
show the reaction diagram
-
-
-
?
trans-2-decen-1-al + NADPH + H+
?
show the reaction diagram
-
-
-
?
trans-2-hexen-1-al + NADPH + H+
?
show the reaction diagram
-
-
-
?
trans-2-nonen-1-al + NADPH + H+
?
show the reaction diagram
-
-
-
?
1-hydroxynonen-4-one + NADPH
1,4-dihydroxynon-2-ene + NADP+
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-(5-oxovaleryl)sn-glycero-3-phosphocholine + NADPH
1-palmitoyl-2-(5-hydroxyvaleryl)sn-glycero-3-phosphocholine + NADP+
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-(5-oxovaleryl)sn-glycero-3-phosphocholine + NADPH + H+
? + NADP+
show the reaction diagram
ALR2
-
-
?
11-deoxyisocorticosterone + NAD(P)H
?
show the reaction diagram
-
-
-
-
?
2,3-bornanedione + NAD(P)H
?
show the reaction diagram
-
-
-
-
?
2-D-deoxygalactose + NADPH
?
show the reaction diagram
-
-
-
-
?
20-isocortisol + NAD(P)H
?
show the reaction diagram
-
-
-
-
?
20alpha-isocorticosterone + NAD(P)H
?
show the reaction diagram
4-hydroxyphenylacetaldehyde + NAD(P)H
4-hydroxyphenylethyl alcohol + NAD(P)+
show the reaction diagram
-
-
-
-
?
4-hydroxyphenylglycolaldehyde + NAD(P)H
?
show the reaction diagram
-
-
-
-
?
4-nitrobenzaldehyde + NAD(P)H
4-nitrobenzyl alcohol + NAD(P)+
show the reaction diagram
-
-
-
-
?
4-nitrobenzaldehyde + NADPH + H+
4-nitrobenzyl alcohol + NADP+
show the reaction diagram
-
-
-
-
?
4-oxonon-2-enal + NADPH
1-hydroxynonen-4-one + NADP+
show the reaction diagram
-
-
-
-
?
8-acetyl-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-aza-benzo[de]anthracen-10-one + NADPH + H+
? + NADP+
show the reaction diagram
fluorogenic synthetic substrate
-
-
?
alditol + NAD(P)+
aldose + NAD(P)H
show the reaction diagram
-
-
-
-
r
aldose + NAD(P)H
alditol + NAD(P)+
show the reaction diagram
aldose + NADPH + H+
alditol + NADP+
show the reaction diagram
benzyl alcohol + oxidized 3-acetylpyridine adenine dinucleotide + H+
benzaldehyde + reduced 3-acetylpyridine adenine dinucleotide
show the reaction diagram
butyraldehyde + NAD(P)H
butanol + NAD(P)+
show the reaction diagram
-
-
-
-
?
D-erythrose + NAD(P)H
erythritol + NAD(P)+
show the reaction diagram
-
-
-
-
r
D-erythrose + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
D-galactose + NAD(P)H
dulcitol + NAD(P)+
show the reaction diagram
D-galactose + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
D-glucose + NAD(P)H
sorbitol + NAD(P)+
show the reaction diagram
D-glucose + NADPH + H+
D-sorbitol + NADP+
show the reaction diagram
D-glucose + NADPH + H+
sorbitol + NADP+
show the reaction diagram
D-glucuronate + NAD(P)H
?
show the reaction diagram
-
-
-
-
r
D-glucuronolactone + NADPH
?
show the reaction diagram
-
-
-
-
?
D-glyceraldehyde + NAD(P)H
glycerol + NAD(P)+
show the reaction diagram
-
-
-
-
-
D-lyxose + NADPH
arabitol + NADP+
show the reaction diagram
-
-
-
-
-
D-ribose + NAD(P)H
ribitol + NAD(P)+
show the reaction diagram
-
-
-
-
r
D-ribose + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
D-xylose + NAD(P)H
xylitol + NAD(P)+
show the reaction diagram
-
-
-
-
r
D-xylose + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
D-xylose + NADPH + H+
xylitol + NADP+
show the reaction diagram
-
-
-
-
?
decanal + NAD(P)H
decanol + NAD(P)+
show the reaction diagram
-
-
-
-
?
DL-glyceraldehyde + NAD(P)H
glycerol + NAD(P)+
show the reaction diagram
DL-glyceraldehyde + NADPH
glycerol + NAD(P)+
show the reaction diagram
-
-
-
-
?
DL-glyceraldehyde + NADPH
glycerol + NADP+
show the reaction diagram
DL-glyceraldehyde + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
DL-glyceraldehyde + NADPH + H+
DL-glycerol + NADP+
show the reaction diagram
DL-glyceraldehyde + NADPH + H+
glycerol + NADP+
show the reaction diagram
glucose + NADPH
sorbitol + NADP+
show the reaction diagram
-
-
-
-
?
glutathione-S-4-oxonon-2-enal + NADPH
S-(1-hydroxy-4-oxonona-3-yl)glutathione + NADP+
show the reaction diagram
-
-
-
-
?
glyceraldehyde + NADPH + H+
glycerol + NADP+
show the reaction diagram
-
-
-
-
?
indole-3-acetaldehyde + NAD(P)H
indole-3-ethanol + NAD(P)+
show the reaction diagram
-
-
-
-
?
L-arabinose + NAD(P)H
L-arabitol + NAD(P)+
show the reaction diagram
-
-
-
-
r
L-idose + NADPH + H+
alditol + NADP+
show the reaction diagram
-
-
-
-
?
L-threose + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
L-xylose + NAD(P)H
L-xylitol + NAD(P)+
show the reaction diagram
phenylglyoxal + NAD(P)H
?
show the reaction diagram
-
-
-
-
?
propionaldehyde + NAD(P)H
propanol + NAD(P)+
show the reaction diagram
-
-
-
-
?
pyridinecarboxaldehyde + NAD(P)H
pyridylmethanol + NAD(P)+
show the reaction diagram
-
2-, 3- and 4-pyridinecarboxaldehyde
-
-
?
sorbitol + NAD+
D-fructose + NADH + H+
show the reaction diagram
-
aldehyde reductase, ALR1
-
-
?
succinic semialdehyde + NADH + H+
4-hydroxybutyrate + NAD+
show the reaction diagram
-
-
-
-
?
xylitol + NAD(P)+
D-xylose + NAD(P)H + H+
show the reaction diagram
-
-
-
-
r
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
aldose + NAD(P)H
alditol + NAD(P)+
show the reaction diagram
-
-
-
-
r
aldose + NADPH + H+
alditol + NADP+
show the reaction diagram
D-glucose + NADPH + H+
D-sorbitol + NADP+
show the reaction diagram
D-glucose + NADPH + H+
sorbitol + NADP+
show the reaction diagram
DL-glyceraldehyde + NADPH + H+
DL-glycerol + NADP+
show the reaction diagram
-
-
-
-
?
DL-glyceraldehyde + NADPH + H+
glycerol + NADP+
show the reaction diagram
-
-
-
-
?
glyceraldehyde + NADPH + H+
glycerol + NADP+
show the reaction diagram
-
-
-
-
?
sorbitol + NAD+
D-fructose + NADH + H+
show the reaction diagram
-
aldehyde reductase, ALR1
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NAD+
-
-
NADPH
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Li2SO4
Mg2+
-
required
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
17alpha-estradiol
-
-
17beta-estradiol
-
-
4-androsten-17alpha-ol-3-one
-
i.e. epitestosterone
4-androsten-17beta-ol-3-one
-
i.e. testosterone
4-androstene-3,17-dione
-
-
4-pregenene-21-ol-3,20-dione
-
i.e. 11-deoxycorticosterone
4-pregnene-11beta,17alpha,21-triol-3,20-dione
-
i.e. cortisol
4-pregnene-11beta,21-diol-3,20-dione
-
i.e. corticosterone
4-pregnene-17alpha,21-diol-3,11,20-trione
-
i.e. cortisone
4-pregnene-18-al-11beta,21-diol-3,20-dione
-
i.e. aldosteron
5-androsten-3beta-ol-17-one
-
i.e. dehydroepiandrosterone
5-cholenic acid-3beta-ol
-
-
5alpha-Androstan-17alpha-ol-3-one
-
-
5alpha-androstan-17beta-ol-3-one
-
i.e. 5alpha-dehydrotestosterone
5alpha-Androstan-3alpha-ol-17-one
-
-
5alpha-Androstan-3beta-ol-17-one
-
competitive inhibition with respect to geraniol
5alpha-androstane-3,17-dione
-
competitive inhibition with respect to geraniol
5alpha-androstane-3alpha,17beta-diol
-
-
5alpha-Androstane-3beta,17beta-diol
-
-
5alpha-cholanic acid-3beta-ol
-
-
5alpha-pregnan-3beta-ol-20-one
-
-
5alpha-pregnane-21-ol-3,20-dione
-
-
5alpha-pregnane-3,20-dione
-
competitive inhibition with respect to geraniol
5beta-androstan-17beta-ol-3-one
-
-
5beta-Androstan-3alpha-ol-17-one
-
-
5beta-androstan-3beta-ol-17-one
-
-
5beta-androstane-3,17-dione
-
-
5beta-androstane-3beta,17beta-diol
-
-
5beta-cholan-24-ol
-
-
5beta-cholanic acid
-
competitive inhibition with respect to geraniol
5beta-cholanic acid methyl ester
-
-
5beta-cholanic acid-3-one
-
-
5beta-cholanic acid-3alpha,12alpha-diol
-
i.e. chenodeoxycholic acid
5beta-cholanic acid-3alpha,6alpha-diol
-
i.e. hyodeoxycholic acid
5beta-cholanic acid-3alpha,7alpha,12alpha-triol
-
i.e. cholic acid
5beta-cholanic acid-3alpha,7alpha-diol
-
i.e. deoxycholic acid
5beta-cholanic acid-3alpha,7beta-diol
-
i.e. ursodeoxycholic acid
5beta-cholanic acid-3alpha-ol
-
i.e. lithocholic acid
5beta-cholanic acid-3beta-ol
-
i.e. isolithocholic acid
5beta-Pregnan-3alpha-ol-20-one
-
-
5beta-Pregnan-3beta-ol-20-one
-
-
5beta-pregnane-3,20-dione
-
-
Cibacron blue F3GA
-
competitive inhibition with respect to NADP+, noncompetitive inhibition with respect to geraniol
estriol
-
i.e. 16alpha-hydroxyestradiol
estrone
-
-
fidarestat
-
an inhibitor highly selective for aldose reductase (AKR1B1, EC 1.1.1.21) versus aldehyde reductase (AKR1A1, EC 1.1.1.2). Inhibitor binding site and structure comparisons of enzymes AKR1B1 and AKR1B10, overview. Fidarestat is specific for aldose reductase AKR1B1 versus aldose reductae-like AKR1B10
glycochenodeoxycholic acid
-
-
glycolithocholic acid
-
; competitive inhibition with respect to geraniol
isolithocholic acid
-
uncompetitive inhibition with respect to NADP+, competitive inhibition with respect to geraniol
lithocholic acid
-
competitive inhibition with respect to geraniol
Tolrestat
-
uncompetitive inhibition with respect to NADP+, competitive inhibition with respect to geraniol
(1H-indol-1-yl)acetic acid
-
-
(2,3-dihydrocyclopenta[b]indol-4(1H)-yl)acetic acid
-
-
(2-[(4-bromo-2-fluorobenzyl)carbamoyl]-5-chlorophenoxy)acetic acid
-
thermodynamic binding data for isoform ALR2 and mutants
(2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
-
-
(2R)-1-[(benzyloxy)carbonyl]-2,3-dihydro-1H-indole-2-carboxylic acid
-
CC-13401
(2S)-3beta,7,4'-trihydroxy-5-methoxy-8-(gamma,gamma-dimethylallyl)-flavanone
-
-
(2S)-7,4'-dihydroxy-5-methoxy-8-(gamma,gamma-dimethylallyl)-flavanone
-
potent inhibitor of recombinant human aldose reductase
(3-benzothiazol-2-yl-pyrrol-1-yl)acetic acid
-
50% inhibition at 49 nM
(3-sulfanyl-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
-
-
(3-[(5-chloro-1,3-benzothiazol-2-yl)methyl]-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetic acid
-
thermodynamic binding data for isoform ALR2 and mutants
(3-[[(2-fluorophenyl)methyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
-
-
(3-[[2-oxo-2-(2,4,6-trimethylanilino)ethyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
-
-
(4-benzothiazol-2-yl-2-benzoylpyrrol-1-yl)acetic acid
-
50% inhibition at 45 nM
(4-hydroxy-3-methoxyphenyl)acetonitrile
-
IC50: 0.0244 mM
(4-hydroxy-3-methoxyphenyl)methamine
-
IC50: 0.0634 mM
(4-hydroxyphenyl)(6-hydroxypyrazin-2-yl)methanone
-
isolated from red ascidian Botryllus leachi, pyrazine derivative, IC50: 0.0414 mM
(4-hydroxyphenyl)[4-(4-hydroxyphenyl)-1H-imidazol-2-yl]methanone
-
isolated from red ascidian Botryllus leachi, imidazole derivative, IC50: 0.0214 mM
(4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indol-5-yl)acetic acid
-
-
(5-chloro-2-[(3-nitrobenzyl)carbamoyl]phenoxy)acetic acid
-
thermodynamic binding data for isoform ALR2 and mutants
(5-chloro-2-[(4-cyanobenzyl)carbamoyl]phenoxy)acetic acid
-
-
(5-methylIndoleDs)1-(3-(3,4,5-trimethoxyphenyl)-3-(5-methyl-1H-indol-3-yl)propanoyl)-4-(5-methyl-1H-indol-3-yl)piperidin-2-one
-
-
(5-methylIndoleMs)1-(3-(3,4,5-trimethoxyphenyl)-3-(5-methyl-1H-indol-3-yl)propanoyl)-5,6-dihydropyridin-2(1H)-one
-
-
(5Z)-3-chloro-4-(3,5-dibromo-4-hydroxyphenyl)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2(5H)-one
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.019 mM
(5Z)-3-chloro-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(4-hydroxyphenyl)furan-2(5H)-one
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.0008 mM
(5Z)-4-(3,5-dibromo-4-hydroxyphenyl)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2(5H)-one
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.020 mM
(5Z)-4-(3-bromo-4-hydroxyphenyl)-3-chloro-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2(5H)-one
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.013 mM
(5Z)-4-(3-bromo-4-hydroxyphenyl)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2(5H)-one
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.048 mM
(5Z)-4-(3-bromo-4-hydroxyphenyl)-5-[(3-bromo-4-hydroxyphenyl)methylidene]-3-chlorofuran-2(5H)-one
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.017 mM
(5Z)-5-(3-aminobenzylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 4.69
(5Z)-5-(3-fluorobenzylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 5.04
(5Z)-5-(3-hydroxybenzylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 4.97
(5Z)-5-(3-methoxybenzylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 4.88
(5Z)-5-(3-methylbenzylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 5.03
(5Z)-5-(3-phenoxybenzylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 5.21
(5Z)-5-(3-{(E)-[(4-hydroxyphenyl)imino]methyl}benzylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 5.73
(5Z)-5-(4-fluorobenzylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 5.09
(5Z)-5-(4-hydroxy-3-methoxybenzylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 4.93
(5Z)-5-(4-hydroxybenzylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 5.05
(5Z)-5-(4-methoxybenzylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 4.39
(5Z)-5-(4-{(E)-[(4-hydroxyphenyl)imino]methyl}benzylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 4.64
(5Z)-5-(naphthalen-1-ylmethylidene)-1,3-thiazolidine-2,4-dione
-
pIC50 is 4.97
(5Z)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(4-hydroxyphenyl)furan-2(5H)-one
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.057 mM
(5Z)-5-[(3-bromo-4-hydroxyphenyl)methylidene]-3-chloro-4-(4-hydroxyphenyl)furan-2(5H)-one
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.046 mM
(5Z)-5-[3-(trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dione
-
pIC50 is 4.89
(5Z)-5-[4-(trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dione
-
pIC50 is 4.50
(6H-indolo[2,3-b]quinoxalin-6-yl)acetic acid
-
-
(7H-indolo[2',3':5,6][1,2,4]triazino[2,3-a]benzimidazol-7-yl)acetic acid
-
uncompetitive
(8-methyl-3-[[2-oxo-2-(propylamino)ethyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
-
-
(E)-1-(3-(1,3-diphenyl-1H-pyrazol-4-yl)acryloyl)-5,6-dihydropyridin-2(1H)-one
-
-
(E)-1-(3-(2,5-dimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one
-
-
(E)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)piperidin-2-one
-
-
(E)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)pyrrolidin-2-one
-
-
(E)-1-(3-(3-(trifluoromethyl)phenyl)acryloyl)-5,6-dihydropyridin-2(1)-one
-
-
(E)-1-(3-(3-methyl-1-phenyl-1H-pyrazol-4-yl)acryloyl)-5,6-dihydropyridin-2(1H)-one
-
-
(E)-1-(3-(3-phenoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one
-
-
(E)-1-(3-(4-bromophenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one
-
-
(E)-1-(3-(4-chlorophenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one
-
-
(E)-1-(3-(benzo[d][1,3]dioxol-5-yl)acryloyl)-5,6-dihydropyridin-2(1H)-one
-
-
(E)-1-(3-(furan-2-yl)acryloyl)-5,6-dihydropyridin-2(1H)-one
-
-
(E)-1-(3-(naphthalen-2-yl)acryloyl)-5,6-dihydropyridin-2(1H)-one
-
-
(E)-1-(3-(pyridin-2-yl)acryloyl)-5,6-dihydropyridin-2(1H)-one
-
-
(E)-1-(3-(thiophen-2-yl)acryloyl)-5,6-dihydropyridin-2(1H)-one
-
-
(E)-1-(3-mesitylacryloyl)-5,6-dihydropyridin-2(1H)-one
-
-
(E)-1-(4-benzylpiperazin-1-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
-
-
(E)-1-(4-methylpiperazin-1-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
-
-
(E)-1-(4-phenylpiperazin-1-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
-
-
(E)-1-(piperidin-1-yl)-3-(3,4,5-trimethoxyphenyl) prop-2-en-1-one
-
-
(E)-1-(pyrrolidin-1-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
-
-
(E)-2-(3-(3,4,5-trimethoxyphenyl)acryloyl)benzo[d]isothiazol-3(2H)-one
-
-
(E)-2-(3-(3,4,5-trimethoxyphenyl)acryloyl)isoindolin-1-one
-
-
(E)-3-((4-chlorophenyl)(hydroxy)methyl)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one
-
-
(E)-3-((4-fluorophenyl)(hydroxy)methyl)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one
-
-
(E)-3-(3-(3,4,5-trimethoxyphenyl)acryloyl)benzo[d]oxazol-2(3H)-one
-
-
(E)-3-(5-(3-nitrophenyl)furan-2-yl)acrylic acid
-
-
(E)-3-(hydroxy(2-nitrophenyl)methyl)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one
-
-
(E)-3-(hydroxy(4-nitrophenyl)methyl)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one
-
-
(E)-3-(hydroxy(naphthalen-2-yl)methyl)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one
-
-
(E)-3-(hydroxy(p-tolyl)methyl)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one
-
-
(E)-3-(hydroxy(phenyl)methyl)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one
-
-
(E)-3-(hydroxy(pyridin-2-yl)methyl)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one
-
-
(E)-3-(hydroxy(thiophen-2-yl)methyl)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one
-
-
(E)-4-(hydroxy(2-oxo-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-1,2,5,6-tetrahydropyridin-3-yl)methyl)benzonitrile
-
-
(E)-methyl 3-(3,4,5-trimethoxyphenyl)acrylate
-
-
(E)-N-ethanethioyl-3-(3,4,5-trimethoxyphenyl)acrylamide
-
-
(E,E)-5[2-methyl-3-phenyl-2-propenylidene-4-oxo-2-thioxo-3-thiazolidine]acetic acid
(NH4)2SO4
-
0.05 mM: slight inhibition, 400 mM: activation
(S)-6-fluorospiro[chroman-4,5'-imidazolidine]-2',4'-dione
(Z)-2-(5-biphenyl-4-ylmethylene-2,4-dioxothiazolidin-3-yl)-N-hydroxyacetamide
-
-
(Z)-2-(5-biphenyl-4-ylmethylene-2,4-dioxothiazolidin-3-yl)acetamide
-
18% inhibition at 0.0125 mM
(Z)-2-(5-naphthalen-1-ylmethylene-2,4-dioxothiazolidin-3-yl)acetamide
-
32% inhibition at 0.0125 mM
(Z)-2-(5-naphthalen-2-ylmethylene-2,4-dioxothiazolidin-3-yl)acetamide
-
3% inhibition at 0.0125 mM
(Z)-2-[2,4-dioxo-5-(3-phenoxybenzylidene)thiazolidin-3-yl]acetamide
-
8% inhibition at 0.0125 mM
(Z)-2-[5-(3-hydroxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetamide
-
16% inhibition at 0.0125 mM
(Z)-2-[5-(3-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetamide
-
10% inhibition at 0.0125 mM
(Z)-2-[5-(4-benzyloxybenzylidene)-2,4-dioxothiazolidin-3-yl]-N-hydroxyacetamide
-
-
(Z)-2-[5-(4-hydroxy-3-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetamide
-
-
(Z)-2-[5-(4-hydroxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetamide
-
31% inhibition at 0.0125 mM
(Z)-N-hydroxy-2-(5-naphthalen-1-ylmethylene-2,4-dioxothiazolidin-3-yl)acetamide
-
-
(Z)-N-hydroxy-2-(5-naphthalen-2-ylmethylene-2,4-dioxothiazolidin-3-yl)acetamide
-
39% inhibition at 0.025 mM
(Z)-N-hydroxy-2-[2,4-dioxo-5-(3-phenoxybenzylidene)-thiazolidin-3-yl]acetamide
-
-
(Z)-N-hydroxy-2-[2,4-dioxo-5-(4-phenoxybenzylidene)-thiazolidin-3-yl]acetamide
-
-
(Z)-N-hydroxy-2-[5-(4-hydroxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetamide
-
-
([2-[(4-methoxy-1-methyl-1H-indazol-3-yl)amino]-2-oxoethyl]sulfanyl)acetic acid
-
HTS-03834
([5-(5-nitrofuran-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl)acetic acid
-
crystallization data
1-((2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)penta-2,4-dienoyl)-5,6-dihydropyridin-2(1H)-one
-
-
1-((2E,4E,6E)-7-(3,4,5-trimethoxyphenyl)hepta-2,4,6-trienoyl)-5,6-dihydropyridin-2(1H)-one
-
-
1-(2-chlorobenzoyl)-5,6-dihydropyridin-2(1H)-one
-
-
1-(2-iodobenzoyl)-5,6-dihydropyridin-2(1H)-one
-
-
1-(3-(1-benzyl-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)propanoyl)-4-(1-benzyl-1H-indol-3-yl)piperidin-2-one
-
-
1-(3-(1-benzyl-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)propanoyl)-5,6-dihydropyridin-2(1H)-one
-
-
1-(3-(1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)propanoyl)-4-(1H-indol-3-yl)piperidin-2-one
-
-
1-(3-(1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)propanoyl)-5,6-dihydropyridin-2(1H)-one
-
-
1-(3-(3,4,5-trimethoxyphenyl)-3-(1-methyl-1H-indol-3-yl)propanoyl)-4-(1-methyl-1H-indol-3-yl)piperidin-2-one
-
-
1-(3-(3,4,5-trimethoxyphenyl)-3-(1-methyl-1H-indol-3-yl)propanoyl)-5,6-dihydropyridin-2(1H)-one
-
-
1-(3-(3,4,5-trimethoxyphenyl)-3-(2-methyl-1H-indol-3-yl)propanoyl)-4-(2-methyl-1H-indol-3-yl)piperidin-2-one
-
-
1-(3-(3,4,5-trimethoxyphenyl)-3-(2-phenyl-1H-indol-3-yl)propanoyl)-4-(2-phenyl-1H-indol-3-yl)piperidin-2-one
-
-
1-(3-(3,4,5-trimethoxyphenyl)-3-(5-methoxy-1H-indol-3-yl)propanoyl)-4-(5-methoxy-1H-indol-3-yl)piperidin-2-one
-
-
1-(3-(3,4,5-trimethoxyphenyl)-3-(5-nitro-1H-indol-3-yl)propanoyl)-4-(5-nitro-1H-indol-3-yl)piperidin-2-one
-
-
1-(3-(3,4,5-trimethoxyphenyl)-3-(5-nitro-1H-indol-3-yl)propanoyl)-5,6-dihydropyridin-2(1H)-one
-
-
1-(3-(5-bromo-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)propanoyl)-4-(5-bromo-1H-indol-3-yl)piperidin-2-one
-
-
1-(3-(5-bromo-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)propanoyl)-5,6-dihydropyridin-2(1H)-one
-
-
1-(3-(5-fluoro-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)propanoyl)-4-(5-fluoro-1H-indol-3-yl)piperidin-2-one
-
-
1-(3-(5-fluoro-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)propanoyl)-5,6-dihydropyridin-2(1H)-one
-
-
1-(3-(5-iodo-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)propanoyl)-4-(5-iodo-1H-indol-3-yl)piperidin-2-one
-
-
1-(3-(5-iodo-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)propanoyl)-5,6-dihydropyridin-2(1H)-one
-
-
1-(3-(5-methoxy-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)propanoyl)-5,6-dihydropyridin-2(1H)-one
-
-
1-(4-fluorobenzoyl)-5,6-dihydropyridin-2(1H)-one
-
-
1-(4-nitrobenzoyl)-5,6-dihydropyridin-2(1H)-one
-
-
1-butyl-2-[[(4-oxo-3,4-dihydroquinazolin-2-yl)methyl]sulfanyl]-1H-benzimidazole-5-sulfonamide
classical competitive mechanism. No significant influence on 11beta-HSD activities
1-cinnamoyl-5,6-dihydropyridin-2(1H)-one
-
-
1-O-Galloyl-beta-D-glucose
-
i.e. beta-glucogallin or BGG, a major component of the Emblica officinalis medicinal plant, and a stable, potent, and specific inhibitor of aldose reductase, noncompetitive inhibition through binding the active site of AKR1B1, occupying both the anionic and the specificity pockets
1-[3-(2-phenyl-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)propanoyl]-5,6-dihydropyridin-2(1H)-one
-
-
2,1,3-benzoxadiazol-5-yl 5-chlorothiophene-2-sulfonate
-
KM-07100
2,2'-[sulfonylbis(benzene-4,1-diyliminomethylylidene)]dipropanedinitrile
-
BTB-06667
2,5-dihydro-3H-[1,2,4]triazino[5,6-b]indole-3-thione
-
-
2,6-dichlorophenylacetic acid
-
competitive
2-(3,4-dimethoxyphenyl)-ethanoic acid
-
IC50: 0.0303 mM
2-(4-hydroxy-3-methoxyphenyl)ethanoic acid
-
derived from ginger rhizom, Zingiber officinale, IC50: 0.0185 mM, suppresses nt only sorbitol accumulation in human erythrocytes
2-(4-hydroxy-3-methoxyphenyl)ethanol
-
derived from ginger rhizom, Zingiber officinale, IC50: 0.0192 mM, suppresses sorbitol accumulation in human erythrocytes
2-(carboxymethyl)-1-oxo-1,2-dihydronaphtho[1,2-d]isothiazole-4-carboxylic acid 3,3-dioxide
-
crystallization data
2-amino-4-oxo-3,4-dihydropteridine-6-carboxylic acid
-
-
2-amino-4-oxo-3,4-dihydropteridine-7-carboxylic acid
-
-
2-bromophenylacetic acid
-
competitive
2-Chlorophenylacetic acid
-
competitive
2-hydroxyphenylacetic acid
-
competitive
2-napthylacetic acid
-
competitive
2-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]-4-phenylbutanoic acid
-
-
2-[(4-fluorobenzyl)[(2-fluorophenyl)sulfonyl]amino]-N-[2-(3-fluorophenyl)ethyl]acetamide
-
2-[2-(carboxymethoxy)-2-oxoethyl]-1-oxo-1,2-dihydronaphtho[1,2-d]isothiazole-4-carboxylic acid 3,3-dioxide
-
crystallization data
3,3-Tetramethylene glutaric acid
-
-
3,4-dinitro-2,5-bis(phenylsulfanyl)thiophene
-
SEW-05367
3,5-dichlorosalicylic acid
-
uncompetitive inhibition
3-(1H-indol-1-yl)propanoic acid
-
-
3-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
-
a gamma,gamma-dimethylallyl type prenylated isoflavonoid
3-(2-phenylthiazole-4-yl)propanoic acid
-
-
3-(3,4,5-trimethoxyphenyl)-3-(2-methyl-1H-indol-3-yl)propanoic acid
-
-
3-(4-hydroxy-3-methoxyphenyl)propanol
-
IC50: 0.283 mM
3-(4-nitrophenyl)-2-[(phenylsulfonyl)amino]propanoic acid
-
SPB-08302
3-(5-(3-(trifluormethyl)phenyl)thiophene-2-yl)propanoic acid
-
-
3-(5-(3-acetylphenyl)furan-2-yl)propanoic acid
-
-
3-(5-(3-aminophenyl)furan-2-yl)propanoic acid
-
-
3-(5-(3-methoxyphenyl)furan-2-yl)propanoic acid
-
-
3-(5-(3-methoxyphenyl)thiophene-2-yl)propanoic acid
-
-
3-(5-(3-methylphenyl)furan-2-yl)propanoic acid
-
-
3-(5-(3-methylphenyl)thiophene-2-yl)propanoic acid
-
-
3-(5-(3-methylsulfonyl)phenylfuran-2-yl)propanoic acid
-
-
3-(5-(3-nitrophenyl)furan-2-yl)propanoic acid
-
-
3-(5-(3-nitrophenyl)thiophene-2-yl)propanoic acid
-
-
3-(5-(3-trifluormethyl)phenylfuran-2-yl)propanoic acid
-
-
3-(5-phenylfuran-2-yl)propanoic acid
-
-
3-(5-phenylthiophene-2-yl)propanoic acid
-
-
3-(5-pyridine-2-yl-furan-2-yl)propanoic acid
-
-
3-(5-pyridine-3-yl-furan-2-yl)propanoic acid
-
-
3-benzyl-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl 4-methylbenzenesulfonate
-
NRB-05245
3-hydroxybutyrate
-
-
3-hydroxybutyric acid
-
-
3-[(4-bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid
-
recombinant from baculovirus system in Spodoptera frugiperda cells
3-[3,4-dihydroxy-5-(3-methylbut-2-en-1-yl)phenyl]-5,7-dihydroxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
-
a gamma,gamma-dimethylallyl type prenylated isoflavonoid
3-[3-[(diethylamino)methyl]-1H-indol-1-yl]propanoic acid
-
-
4-(4-hydroxy-3-methoxyphenyl)-2-butanone
-
IC50: 0.197 mM
4-(4-hydroxy-3-methoxyphenyl)butanol
-
IC50: 0.642 mM
4-(5-(3-methylphenyl)thiophene-2-yl)butanoic acid
-
-
4-(5-phenylthiophene-2-yl)butanoic acid
-
-
4-hydroxy-3-methoxyphenol
-
IC50: 0.273 mM
4-hydroxy-3-methoxyphenyl methanol
-
IC50: 0.0244 mM
4-hydroxybenzoic acid
-
-
4-oxo-4-(5-(3-methylphenyl)thiophene-2-yl)butanoic acid
-
-
4-oxo-4-(5-phenylthiophen-2-yl)butanoic acid
-
-
4-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]butanoic acid
-
-
4-[3-(3-nitrophenyl)-1,2,4-oxadiazol-5-yl]butanoic acid
-
crystallization data
4-[3-(5-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidin-6-yl)-1,2,4-oxadiazol-5-yl]butanoic acid
-
SB-02066; SEW-01456
4-[5,7-dimethoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol
-
a gamma,gamma-dimethylallyl type prenylated isoflavonoid
4-[7-hydroxy-5-methoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol
-
a gamma,gamma-dimethylallyl type prenylated isoflavonoid
5,5-diphenylhydantoin
-
-
5,6-dihydro-1-((E)-3-(3,4,5-trimethoxyphenyl)acryloyl)pyridin-2(1H)-one
-
-
5-(3-phenoxybenzyl)-1,3-thiazolidine-2,4-dione
-
pIC50 is 4.10
5-(4-phenoxybenzyl)-1,3-thiazolidine-2,4-dione
-
pIC50 is 4.39
5-(biphenyl-4-ylmethyl)-1,3-thiazolidine-2,4-dione
-
pIC50 is 4.18
5-oxo-3-phenyl-5-(quinolin-2-ylamino)pentanoic acid
-
HTS-06058
5-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]pentanoic acid
-
-
5-[4-(benzyloxy)benzyl]-1,3-thiazolidine-2,4-dione
-
pIC50 is 4.50
6',6''-dinitrorosmarinic acid
docking structure with ALR2, overview
6'-nitrorosmarinic acid
docking structure with ALR2, overview
6-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]hexanoic acid
-
-
6-[(5-chloro-3-methyl-1-benzofuran-2-yl)sulfonyl]pyridazin-3(2H)-one
-
binding structure, inhibition mechanism, residues Trp111, His110, Thr113, Tyr48, Trp20, and Phe122, and the residues of the C-terminal loop Ala299, Leu300, Leu301, Ser302, Cys303 are involved, overview
6-[[(di(2,4-dimethoxyphenyl)methylidene)amino]oxy]hexanoic acid
-
-
6-[[(di(3,5-dimethoxyphenyl)methylidene)amino]oxy]hexanoic acid
-
-
6-[[(di(4-methoxy-3-methylphenyl)methylidene)amino]oxy]hexanoic acid
-
-
7-Hydroxy-4-oxo-4H-chromen-2-carboxylic acid
-
-
8-lavandulylkaempferol
-
potent inhibitor of recombinant human aldose reductase
8-methoxy-N-[(1S)-2-methyl-1-(5-phenyl-1H-imidazol-2-yl)propyl]-2H-1-benzopyran-3-carboxamide
-
-
8-methoxy-N-[(5-phenyl-1H-imidazol-2-yl)methyl]-2H-1-benzopyran-3-carboxamide
-
-
8-methoxy-N-[[5-(4-methoxyphenyl)-1H-imidazol-2-yl]methyl]-2H-1-benzopyran-3-carboxamide
-
-
Alrestatin
Barbital
-
-
bezafibrate
-
noncompetitive, IC50: 0.003 mM, recombinant enzyme
butein
-
89.9% inhibition at 0.002 mM
ciprofibrate
-
competitive, IC50: 0.00086 mM, recombinant enzyme
citrate
-
inhibition is pH-dependent
Clofibric acid
-
noncompetitive, IC50: 0.0012 mM, recombinant enzyme
coptisine
-
53.85-61.54% inhibition at 0.075 mg/ml
CuCl2
-
0.007 mM, 20% residual activity, addition of dithiothreitol recovers activity
curcumin
inhibits ALR2 in a non-competitive manner, also inhibits AKR1B10, docking analysis and kinetics, overview. Curcumin is able to suppress sorbitol accumulation in human erythrocytes under high glucose conditions
davallialactone
-
-
desmethylanhydroicaritin
-
potent inhibitor of recombinant human aldose reductase
dithiothreitol
-
increased inhibitory effect of sorbinil
DL-dihydrolipoic acid
-
binds very tight to the enzyme, best inhibitor of the investigated, competitive
DL-lipoamide
-
binds three-fold more weakly than D,L-lipoic acid, competitive
DL-lipoic acid
-
is effective in the treatment of diabetic complications, binds tightly to the enzyme, competitive
ellagic acid
-
-
epalrestat
epiberberine
-
69.23-76.92% inhibition at 0.075 mg/ml
Ethosuccinimide
-
-
ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate
-
an AR inhibitor, abolishes the accumulation of TPA-treated cells in S phase was almost completely
fenofibrate
-
competitive, IC50: 0.00056 mM, recombinant enzyme
ferulic acid
-
-
fidarestat
fisetin
-
31.1% inhibition at 0.002 mM
folic acid
-
-
fustin
-
20.1% inhibition at 0.002 mM
gallic acid
-
-
gemfibrozil
-
noncompetitive, IC50: 0.0065 mM, recombinant enzyme
groenlandicine
-
69.23-76.92% inhibition at 0.075 mg/ml
hexanoic acid
-
competitive
hypholomine B
-
-
IDD 594
imirestat
-
-
indole-1-acetic acid
-
-
indomethacin
-
-
iodoacetate
-
-
isoliquiritigenin
-
-
kuraridin
-
; potent inhibitor of recombinant human aldose reductase
kushenol E
-
potent inhibitor of recombinant human aldose reductase
Li2SO4
-
0.4 M: essential for full activity
lidorestat
liquiritigenin
-
-
lukianol B
-
IC50: 0.0006 mM
Mandelic acid
-
competitive
methyl 3-methyl-2-([2-nitro-4-(trifluoromethyl)phenyl]amino)butanoate
-
methyl [(5Z)-2,4-dioxo-5-(3-phenoxybenzylidene)-1,3-thiazolidin-3-yl]acetate
-
pIC50 is 5.88
methyl [(5Z)-5-(3-aminobenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetate
-
pIC50 is 4.41
methyl [(5Z)-5-(3-methoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetate
-
pIC50 is 5.05
methyl [(5Z)-5-(3-methylbenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetate
-
pIC50 is 5.00
methyl [(5Z)-5-(4-fluorobenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetate
-
pIC50 is 4.89
methyl [(5Z)-5-(4-hydroxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetate
-
pIC50 is 5.21
methyl [5-(3-methoxybenzyl)-2,4-dioxo-1,3-thiazolidin-3-yl]acetate
-
pIC50 is 4.68
methyl {(5Z)-2,4-dioxo-5-[3-(trifluoromethyl)benzylidene]-1,3-thiazolidin-3-yl}acetate
-
pIC50 is 4.54
methyl {(5Z)-2,4-dioxo-5-[4-(trifluoromethyl)benzylidene]-1,3-thiazolidin-3-yl}acetate
-
pIC50 is 5.46
minalrestat
Morin hydrate
-
14.1% inhibition at 0.002 mM
Myricitrin
-
-
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-beta-alanine
-
-
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-alanine
-
-
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-isoleucine
-
-
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-leucine
-
-
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-phenylalanine
-
-
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-serine
-
-
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-tyrosine
-
-
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-valine
-
-
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)glycine
-
-
N-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)glycyl-L-phenylalanine
-
9% inhibition at 10.5 mM
N-(2-phenylethyl)-N-{[4-(trifluoromethyl)phenyl]sulfonyl}glycine
-
-
N-cyclopropyl-N-[cyclopropyl(5-phenyl-1H-imidazol-2-yl)methyl]-2H-1-benzopyran-3-carboxamide
-
-
N-cyclopropyl-N-[cyclopropyl(5-phenyl-1H-imidazol-2-yl)methyl]-8-methoxy-2H-1-benzopyran-3-carboxamide
-
-
N-cyclopropyl-N-[cyclopropyl[5-(pyridin-3-yl)-1H-imidazol-2-yl]methyl]-2H-1-benzopyran-3-carboxamide
-
-
N-cyclopropyl-N-[cyclopropyl[5-(pyridin-3-yl)-1H-imidazol-2-yl]methyl]-8-methoxy-2H-1-benzopyran-3-carboxamide
-
-
N-ethylmaleimide
-
-
N-galloyl beta-D-glucopyranosylamine
-
-
N-tert-butyl-2-(2-chloro-6-methoxy-4-([(3-methyl-5-sulfanyl-4H-1,2,4-triazol-4-yl)amino]methyl)phenoxy)acetamide
-
N-[(1S)-1-[5-(4-bromophenyl)-1H-imidazol-2-yl]-2-methylpropyl]-2H-1-benzopyran-3-carboxamide
-
-
N-[(1S)-1-[5-(4-bromophenyl)-1H-imidazol-2-yl]-2-methylpropyl]-8-methoxy-2H-1-benzopyran-3-carboxamide
-
-
N-[(1S)-2-methyl-1-(5-phenyl-1H-imidazol-2-yl)propyl]-2H-1-benzopyran-3-carboxamide
-
-
N-[(5-phenyl-1H-imidazol-2-yl)methyl]-2H-1-benzopyran-3-carboxamide
-
-
N-[[5-(4-bromophenyl)-1H-imidazol-2-yl]methyl]-2H-1-benzopyran-3-carboxamide
-
-
N-[[5-(4-bromophenyl)-1H-imidazol-2-yl]methyl]-8-methoxy-2H-1-benzopyran-3-carboxamide
-
-
N-[[5-(4-chlorophenyl)-1H-imidazol-2-yl](cyclopropyl)methyl]-N-cyclopropyl-2H-1-benzopyran-3-carboxamide
-
-
N-[[5-(4-chlorophenyl)-1H-imidazol-2-yl](cyclopropyl)methyl]-N-cyclopropyl-8-methoxy-2H-1-benzopyran-3-carboxamide
-
-
N-[[5-(4-chlorophenyl)-1H-imidazol-2-yl]methyl]-2H-1-benzopyran-3-carboxamide
-
-
N-[[5-(4-chlorophenyl)-1H-imidazol-2-yl]methyl]-8-methoxy-2H-1-benzopyran-3-carboxamide
-
-
N-[[5-(4-fluorophenyl)-1H-imidazol-2-yl]methyl]-2H-1-benzopyran-3-carboxamide
-
-
N-[[5-(4-fluorophenyl)-1H-imidazol-2-yl]methyl]-8-methoxy-2H-1-benzopyran-3-carboxamide
-
-
N-[[5-(4-methoxyphenyl)-1H-imidazol-2-yl]methyl]-2H-1-benzopyran-3-carboxamide
-
-
N-[[6-methoxy-5(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglycine
N2-(2-methylaminobenzoyl)tetrahydro-1H-pyrido[3,4-b]indol-1-one
-
i.e. rhetsinine, from Evodia rutaecarpa hot water extract. Rhetsinine inhibits sorbitol accumulation by 79.3% at 0.1 mM in erythrocytes
NaCl
-
-
NADP+
-
-
nitric oxide
-
from NO donors S-nitroso-N-acetylpenicillamine or S-nitrosoglutathione in vivo and in vitro, leads to increased S-glutathiolation of the enzyme
p-catechuic acid
-
-
p-coumaric acid
-
-
p-hydroxymercuribenzoate
-
-
pentagalloyl glucose
-
46.6% inhibition at 0.002 mM
Phenobarbital
-
-
Phenobarbitone
-
-
phenylacetic acid
-
competitive
piplartine
-
-
ponalrestat
protocatechuic acid
-
12.6% inhibition at 0.002 mM
pyrazolo[5,1-c][1,2,4]benzotriazin-8-yl dimethylcarbamate
-
EN-00263
quercetin
quercitrin
-
-
rosmarinic acid
docking structure with ALR2, overview
S-nitrosoglutathione
-
0.05 mM, up to 40% inhibition, possibly due to selctive formation of a single mixed disulfide between glutathione and Cys298
semilicoisoflavone B
-
contains a gamma,gamma-dimethylchromene ring on the aromatic ring
sorbinil
Statil
-
molecular modeling redicts an enhancement of net binding energy of the complex by 33% through replacement of the fluorine atom of statil by a carboxylate group
sulfuretin
-
69.8% inhibition at 0.002 mM
sulindac
-
exhibits both the highest inhibitory activity towards human aldose reductase among popular non-steroidal anti-inflammatory drugs and clear beneficial clinical effects on Type 2 diabetes, uncompetitive inhibition, enzyme binding structure, overview
sulindac sulfide
-
enzyme binding structure, overview
sulindac sulfone
-
enzyme binding structure, overview
syringic acid
-
-
Tolmetin
-
enzyme binding structure, overview
Tolrestat
trans-cinnamic acid
-
-
vanillic acid
-
-
Zenarestat
zopolrestat
[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino](phenyl)acetic acid
-
-
[(5H-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetic acid
-
-
[(5Z)-2,4-dioxo-5-(3-phenoxybenzylidene)-1,3-thiazolidin-3-yl]acetic acid
-
pIC50 is 6.89
[(5Z)-2,4-dioxo-5-(4-phenoxybenzylidene)-1,3-thiazolidin-3-yl]acetic acid
-
pIC50 is 6.09
[(5Z)-5-(3-fluorobenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid
-
pIC50 is 6.13
[(5Z)-5-(3-hydroxy-4-methoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid
-
pIC50 is 6.25
[(5Z)-5-(3-hydroxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid
-
pIC50 is 6.18
[(5Z)-5-(3-methoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid
-
pIC50 is 6.32
[(5Z)-5-(3-methylbenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid
-
pIC50 is 6.19
[(5Z)-5-(3-nitrobenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid
-
pIC50 is 6.31
[(5Z)-5-(4-fluorobenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid
-
pIC50 is 5.94
[(5Z)-5-(4-hydroxy-3-methoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid
-
pIC50 is 6.15
[(5Z)-5-(4-hydroxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid
-
pIC50 is 6.82
[(5Z)-5-(biphenyl-4-ylmethylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid
-
pIC50 is 6.59
[(5Z)-5-(naphthalen-1-ylmethylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid
-
pIC50 is 6.77
[2,4-dioxo-5-(3-phenoxybenzyl)-1,3-thiazolidin-3-yl]acetic acid
-
pIC50 is 6.00
[2,4-dioxo-5-(4-phenoxybenzyl)-1,3-thiazolidin-3-yl]acetic acid
-
pIC50 is 5.55
[3-(2,2-dimethylpropanoyl)-1H-indol-1-yl]acetic acid
-
-
[3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acid
-
-
[3-[(diethylamino)methyl]-1H-indol-1-yl]acetic acid
-
-
[3-[(dimethylamino)methyl]-2-methyl-1H-indol-1-yl]acetic acid
-
-
[3-[(morpholin-4-yl)methyl]-1H-indol-1-yl]acetic acid
-
-
[3-[(propan-2-yl)sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl]acetic acid
-
-
[3-[(pyrrolidin-1-yl)methyl]-1H-indol-1-yl]acetic acid
-
-
[5-(3-carboxymethoxy-4-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetic acid
-
i.e. CMD, a potent inhibitor of ALR2, but not for ALR1, structure molecular modelling, overview. The non-conserved C-terminal residue Leu300 in ALR2, which is Pro301 in ALR1, contributes to inhibitor selectivity
[5-(3-hydroxy-4-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetic acid
-
i.e. HMD, modelling of inhibitor-enzyme active site complex
[5-(3-methoxybenzyl)-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid
-
pIC50 is 5.53
[5-(4-hydroxybenzyl)-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid
-
pIC50 is 5.68
[5-(4-methoxybenzyl)-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid
-
pIC50 is 5.97
[5-(biphenyl-4-ylmethyl)-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid
-
pIC50 is 5.77
[5-fluoro-2-[[[(4,5,7-trifluoro-2-benzothiazolyl)methyl]amino]carbonyl]phenoxy]acetic acid
-
-
[6-ethyl-3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acid
-
-
[6-hydroxy-3-(4-hydroxyphenoxy)pyrazin-2-yl](4-hydroxyphenyl)methanone
-
isolated from red ascidian Botryllus leachi, pyrazine derivative, IC50: 0.0194 mM
[6-methyl-3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acid
-
-
[[(4-methylphenyl)sulfonyl](2-thiophen-2-ylethyl)amino]acetic acid
-
S-12728
{(5Z)-2,4-dioxo-5-[3-(trifluoromethyl)benzylidene]-1,3-thiazolidin-3-yl}acetic acid
-
pIC50 is 6.33
{(5Z)-2,4-dioxo-5-[4-(trifluoromethyl)benzylidene]-1,3-thiazolidin-3-yl}acetic acid
-
pIC50 is 6.34
{(5Z)-5-[3-(carboxymethoxy)-4-ethoxybenzylidene]-2,4-dioxo-1,3-thiazolidin-3-yl}acetic acid
-
pIC50 is 5.85
{(5Z)-5-[3-(carboxymethoxy)benzylidene]-2,4-dioxo-1,3-thiazolidin-3-yl}acetic acid
-
pIC50 is 6.64
{(5Z)-5-[4-(benzyloxy)benzylidene]-2,4-dioxo-1,3-thiazolidin-3-yl}acetic acid
-
pIC50 is 6.55
{(5Z)-5-[4-(carboxymethoxy)-3-methoxybenzylidene]-2,4-dioxo-1,3-thiazolidin-3-yl}acetic acid
-
pIC50 is 6.59
{(5Z)-5-[4-(carboxymethoxy)benzylidene]-2,4-dioxo-1,3-thiazolidin-3-yl}acetic acid
-
pIC50 is 6.22
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(NH4)2SO4
12-O-tetradecanoylphorbol-13-acetate
-
i.e. TPA, induces enzyme expression in A-549 cells and increases the enzyme activity, TPA is a potent tumor promoter, TPA-induced increase in mRNA level and promoter activity of the AR gene is significantly attenuated in the presence of inhibitors of protein kinase C, tyrosine kinase, or nuclear kinase and NF- kB, cycloheximide, actinomycin D, bisindolylmaleimide I, and genistein abolish enzyme induction by TPA
N-(beta-glucopyranosyl)-N2-acetyl-S-nitroso-N-acetylpenicillamine
-
2 mM, up to 7fold increase in activity, possibly due to nitrosation of Cys298
Na2SO4
NaCl
-
increased concentration
NADPH
-
in absence, loss of 60% of activity
peroxynitrite
-
peroxynitrite activates by oxidizing cysteine resiudes to sulfenic acid. C298 is the major site of sulfenic acid formation and oxidation of C298 is necessary and sufficient for enzyme activation by peroxynitrite
pyridoxal 5'-phosphate
-
2,5fold activity at 0,5 mM
SO42-
-
stimulation
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.091
1-butanal
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0044
1-Decanol
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0026
1-Dodecanal
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0027
1-heptanal
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.112
1-hexanal
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.18
1-Hexanol
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0007
1-nonanal
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.011
1-nonanol
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0017
1-octanal
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0006
1-Tetradecanol
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.051
2,3-Hexanedione
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0009
20alpha-hydroxyprogesterone
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0032
21-Dehydrocortisol
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.129
3-deoxyglucosone
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0002
5-Pregnene-3beta,20alpha-diol
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0004
5alpha-pregnan-20alpha-ol-3-one
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0008
5alpha-pregnane-3beta,20alpha-diol
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0097
benzaldehyde
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.3
benzyl alcohol
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.74
D-lactoaldehyde
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
6
DL-glyceraldehyde
-
pH 7.0, 25C, recombinant detagged enzyme
0.025
geraniol
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0004 - 0.0009
geranylgeraniol
21
glycolaldehyde
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
11
Glyoxal
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0022
isatin
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.056
isocaproaldehyde
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.02
nerol
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.13
Pyridine-3-aldehyde
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.49
Pyridine-3-methanol
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0023 - 0.0033
trans,trans-farnesol
0.25
trans-2-buten-1-al
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.004
trans-2-decen-1-al
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.028
trans-2-hexen-1-al
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0034
trans-2-nonen-1-al
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0096
1-palmitoyl-2-(5-oxovaleryl)sn-glycero-3-phosphocholine
-
pH 6.0, 30C
0.001
20alpha-Isocorticosterone
-
and 20alpha-isocortisol, values below
0.01
4-hydroxyphenylacetaldehyde
-
-
0.002 - 0.003
4-nitrobenzaldehyde
0.025
benzaldehyde
-
-
40 - 49.3
D-galactose
57.3 - 205
D-glucose
0.152 - 6.4
D-glucuronate
0.035
D-glyceraldehyde
-
-
506 - 2740
D-Lyxose
5.04 - 1340
D-xylose
0.02 - 84
DL-glyceraldehyde
130.2 - 142
galactose
155
glucose
-
-
0.51
glyceraldehyde
-
-
0.016
Indole-3-acetaldehyde
-
-
0.018
L-glyceraldehyde
4
L-idose
-
pH 6.8, 37C
100 - 1190
L-Xylose
0.25 - 0.62
NADH
0.0032 - 0.232
NADPH
0.02
p-bromobenzaldehyde
-
-
0.005
p-Carboxybenzaldehyde
-
-
0.007
p-nitrobenzaldehyde
-
-
0.011
propionaldehyde
-
-
0.039
Pyridine-3-aldehyde
-
-
102
ribose
-
-
29.77
xylose
-
-
additional information
additional information
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.3
1-butanal
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.05
1-Decanol
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
1.25
1-Dodecanal
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
2
1-heptanal
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
2.37
1-hexanal
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.158
1-Hexanol
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
1.38
1-nonanal
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.065
1-nonanol
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
1.37
1-octanal
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.017
1-Tetradecanol
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
1.32
2,3-Hexanedione
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.004
20alpha-hydroxyprogesterone
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.48
21-Dehydrocortisol
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.75
3-deoxyglucosone
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.006
5-Pregnene-3beta,20alpha-diol
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.008
5alpha-pregnan-20alpha-ol-3-one
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.012
5alpha-pregnane-3beta,20alpha-diol
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
1.73
benzaldehyde
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.167
benzyl alcohol
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
1.87
D-lactoaldehyde
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.567
geraniol
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.078 - 0.165
geranylgeraniol
0.58
glycolaldehyde
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
1.12
Glyoxal
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
1.12
isatin
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
1.43
isocaproaldehyde
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.117
nerol
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
2.5
Pyridine-3-aldehyde
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.042
Pyridine-3-methanol
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.155 - 0.5
trans,trans-farnesol
0.78
trans-2-buten-1-al
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
1.83
trans-2-decen-1-al
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.82
trans-2-hexen-1-al
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
1.34
trans-2-nonen-1-al
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.61
1-palmitoyl-2-(5-oxovaleryl)sn-glycero-3-phosphocholine
-
pH 6.0, 30C
0.64
20alpha-Isocorticosterone
-
20alpha-isocortisol
0.233 - 0.525
D-galactose
0.183 - 126
D-glucose
0.418 - 2.3
D-glucuronate
0.55
D-glyceraldehyde
-
-
0.635 - 1.7
D-xylose
0.09 - 4.6
DL-glyceraldehyde
143
L-idose
-
pH 6.8, 37C
0.76
Phenylglyoxal
-
-
additional information
DL-glyceraldehyde
-
turnover number in mol per seconds for several mutants
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00004 - 0.0078
(5-chloro-2-[(4-cyanobenzyl)carbamoyl]phenoxy)acetic acid
0.00297
6-[[(di(2,4-dimethoxyphenyl)methylidene)amino]oxy]hexanoic acid
-
pH 6.8, 37C
0.00299
6-[[(di(3,5-dimethoxyphenyl)methylidene)amino]oxy]hexanoic acid
-
pH 6.8, 37C
0.00292
6-[[(di(4-methoxy-3-methylphenyl)methylidene)amino]oxy]hexanoic acid
-
pH 6.8, 37C
0.0011 - 0.0026
bezafibrate
-
pH 6.2, 25C, recombinant enzyme
0.00088
ciprofibrate
-
pH 6.2, 25C, recombinant enzyme
0.00124
Clofibric acid
-
pH 6.2, 25C, recombinant enzyme
0.00056
davallialactone
-
pH 6.2, 37C
0.00137
ellagic acid
-
pH 6.2, 37C
0.00056
fenofibrat
-
pH 6.2, 25C, recombinant enzyme
0.0012 - 0.0037
gemfibrozil
-
pH 6.2, 25C, recombinant enzyme
0.00128
hypholomine B
-
pH 6.2, 37C
0.00045
sorbinil
-
pH 6.2, 25C, recombinant enzyme
0.000458
sulindac
-
pH 6.2, temperature not specified in the publication, ALR2
0.0003
sulindac sulfide
-
pH 6.2, temperature not specified in the publication, ALR2
0.000434
sulindac sulfone
-
pH 6.2, temperature not specified in the publication, ALR2
0.000043
zopolrestat
-
pH 6.2, 25C, recombinant enzyme
additional information
additional information
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0033
(17alpha)-17-hydroxyandrost-4-en-3-one
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.012
17alpha-estradiol
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.003
17beta-estradiol
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0016
4-androsten-17beta-ol-3-one
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0005
4-androstene-3,17-dione
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0025
4-pregenene-21-ol-3,20-dione
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.017
4-pregnene-11beta,17alpha,21-triol-3,20-dione
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.005
4-pregnene-11beta,21-diol-3,20-dione
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0022
4-pregnene-17alpha,21-diol-3,11,20-trione
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.022
4-pregnene-18-al-11beta,21-diol-3,20-dione
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0011
5-androsten-3beta-ol-17-one
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00023
5-cholenic acid-3beta-ol
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0057
5alpha-Androstan-17alpha-ol-3-one
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00051
5alpha-androstan-17beta-ol-3-one
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0027
5alpha-Androstan-3alpha-ol-17-one
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00032
5alpha-Androstan-3beta-ol-17-one
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00039
5alpha-androstane-3,17-dione
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0046
5alpha-androstane-3alpha,17beta-diol
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00052
5alpha-Androstane-3beta,17beta-diol
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.000064
5alpha-cholanic acid-3beta-ol
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0005
5alpha-pregnan-3beta-ol-20-one
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00037
5alpha-pregnane-21-ol-3,20-dione
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00044
5alpha-pregnane-3,20-dione
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0042
5beta-androstan-17beta-ol-3-one
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0048
5beta-Androstan-3alpha-ol-17-one
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00033
5beta-androstan-3beta-ol-17-one
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0021
5beta-androstane-3,17-dione
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0016
5beta-androstane-3beta,17beta-diol
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.04
5beta-cholan-24-ol
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.000052
5beta-cholanic acid
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.018
5beta-cholanic acid methyl ester
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00011
5beta-cholanic acid-3-one
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00021
5beta-cholanic acid-3alpha,12alpha-diol
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00026
5beta-cholanic acid-3alpha,6alpha-diol
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0022
5beta-cholanic acid-3alpha,7alpha,12alpha-triol
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0011
5beta-cholanic acid-3alpha,7alpha-diol
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00078
5beta-cholanic acid-3alpha,7beta-diol
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00012
5beta-cholanic acid-3alpha-ol
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.000027
5beta-cholanic acid-3beta-ol
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00055
5beta-Pregnan-3alpha-ol-20-one
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00044
5beta-Pregnan-3beta-ol-20-one
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00078
5beta-pregnane-3,20-dione
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.025
estriol
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0016
estrone
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.0018 - 0.033
fidarestat
0.0071
glycochenodeoxycholic acid
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
0.00071
glycolithocholic acid
Homo sapiens;
-
in 0.1 M potassium phosphate, pH 7.4, at 25C
7.3
(1H-indol-1-yl)acetic acid
Homo sapiens;
-
pH and temperature not specified in the publication
2.87
(2,3-dihydrocyclopenta[b]indol-4(1H)-yl)acetic acid
Homo sapiens;
-
pH and temperature not specified in the publication
0.2572
(2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
Homo sapiens;
-
pH 7.0, 37C
0.04141
(2R)-1-[(benzyloxy)carbonyl]-2,3-dihydro-1H-indole-2-carboxylic acid
Homo sapiens;
-
-
0.00037
(2S)-7,4'-dihydroxy-5-methoxy-8-(gamma,gamma-dimethylallyl)-flavanone
Homo sapiens;
-
-
0.097
(3-sulfanyl-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
Homo sapiens;
-
pH and temperature not specified in the publication
2.24
(3-[[(2-fluorophenyl)methyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
Homo sapiens;
-
pH and temperature not specified in the publication
4.06
(3-[[2-oxo-2-(2,4,6-trimethylanilino)ethyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
Homo sapiens;
-
pH and temperature not specified in the publication
0.0244
(4-hydroxy-3-methoxyphenyl)acetonitrile
Homo sapiens;
-
IC50: 0.0244 mM
0.0634
(4-hydroxy-3-methoxyphenyl)methamine
Homo sapiens;
-
IC50: 0.0634 mM
0.0414
(4-hydroxyphenyl)(6-hydroxypyrazin-2-yl)methanone
Homo sapiens;
-
isolated from red ascidian Botryllus leachi, pyrazine derivative, IC50: 0.0414 mM
0.0214
(4-hydroxyphenyl)[4-(4-hydroxyphenyl)-1H-imidazol-2-yl]methanone
Homo sapiens;
-
isolated from red ascidian Botryllus leachi, imidazole derivative, IC50: 0.0214 mM
11.46
(4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indol-5-yl)acetic acid
Homo sapiens;
-
pH and temperature not specified in the publication
0.019
(5Z)-3-chloro-4-(3,5-dibromo-4-hydroxyphenyl)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2(5H)-one
Homo sapiens;
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.019 mM
0.0008
(5Z)-3-chloro-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(4-hydroxyphenyl)furan-2(5H)-one
Homo sapiens;
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.0008 mM
0.02
(5Z)-4-(3,5-dibromo-4-hydroxyphenyl)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2(5H)-one
Homo sapiens;
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.020 mM
0.013
(5Z)-4-(3-bromo-4-hydroxyphenyl)-3-chloro-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2(5H)-one
Homo sapiens;
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.013 mM
0.048
(5Z)-4-(3-bromo-4-hydroxyphenyl)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2(5H)-one
Homo sapiens;
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.048 mM
0.017
(5Z)-4-(3-bromo-4-hydroxyphenyl)-5-[(3-bromo-4-hydroxyphenyl)methylidene]-3-chlorofuran-2(5H)-one
Homo sapiens;
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.017 mM
0.057
(5Z)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(4-hydroxyphenyl)furan-2(5H)-one
Homo sapiens;
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.057 mM
0.046
(5Z)-5-[(3-bromo-4-hydroxyphenyl)methylidene]-3-chloro-4-(4-hydroxyphenyl)furan-2(5H)-one
Homo sapiens;
-
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.046 mM
2.75
(6H-indolo[2,3-b]quinoxalin-6-yl)acetic acid
Homo sapiens;
-
pH and temperature not specified in the publication
9.95
(7H-indolo[2',3':5,6][1,2,4]triazino[2,3-a]benzimidazol-7-yl)acetic acid
Homo sapiens;
-
pH and temperature not specified in the publication
0.33
(8-methyl-3-[[2-oxo-2-(propylamino)ethyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
Homo sapiens;
-
pH and temperature not specified in the publication
0.019
(E)-3-(5-(3-nitrophenyl)furan-2-yl)acrylic acid
Homo sapiens;
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.0203
(Z)-2-(5-biphenyl-4-ylmethylene-2,4-dioxothiazolidin-3-yl)-N-hydroxyacetamide
Homo sapiens;
-
in 0.25 M potassium phosphate buffer pH 6.8, at 37C
0.00734
(Z)-2-[5-(4-benzyloxybenzylidene)-2,4-dioxothiazolidin-3-yl]-N-hydroxyacetamide
Homo sapiens;
-
in 0.25 M potassium phosphate buffer pH 6.8, at 37C
0.00652
(Z)-2-[5-(4-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetamide
Homo sapiens;
-
in 0.25 M potassium phosphate buffer pH 6.8, at 37C
0.0042
(Z)-N-hydroxy-2-(5-naphthalen-1-ylmethylene-2,4-dioxothiazolidin-3-yl)acetamide
Homo sapiens;
-
in 0.25 M potassium phosphate buffer pH 6.8, at 37C
0.0127
(Z)-N-hydroxy-2-[2,4-dioxo-5-(3-phenoxybenzylidene)-thiazolidin-3-yl]acetamide
Homo sapiens;
-
in 0.25 M potassium phosphate buffer pH 6.8, at 37C
0.00367
(Z)-N-hydroxy-2-[2,4-dioxo-5-(4-phenoxybenzylidene)-thiazolidin-3-yl]acetamide
Homo sapiens;
-
in 0.25 M potassium phosphate buffer pH 6.8, at 37C
0.00179
(Z)-N-hydroxy-2-[5-(4-hydroxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetamide
Homo sapiens;
-
in 0.25 M potassium phosphate buffer pH 6.8, at 37C
0.07764
([2-[(4-methoxy-1-methyl-1H-indazol-3-yl)amino]-2-oxoethyl]sulfanyl)acetic acid
Homo sapiens;
-
-
0.00029
1-butyl-2-[[(4-oxo-3,4-dihydroquinazolin-2-yl)methyl]sulfanyl]-1H-benzimidazole-5-sulfonamide
Homo sapiens;
P42330
pH 6.6, temperature not specified in the publication
0.008
1-O-Galloyl-beta-D-glucose
Homo sapiens;
-
pH and temperature not specified in the publication
0.03561
2,1,3-benzoxadiazol-5-yl 5-chlorothiophene-2-sulfonate
Homo sapiens;
-
-
0.5271
2,2'-[sulfonylbis(benzene-4,1-diyliminomethylylidene)]dipropanedinitrile
Homo sapiens;
-
-
4.41
2,5-dihydro-3H-[1,2,4]triazino[5,6-b]indole-3-thione
Homo sapiens;
-
pH and temperature not specified in the publication
0.0303
2-(3,4-dimethoxyphenyl)-ethanoic acid
Homo sapiens;
-
IC50: 0.0303 mM
0.0185
2-(4-hydroxy-3-methoxyphenyl)ethanoic acid
Homo sapiens;
-
derived from ginger rhizom, Zingiber officinale, IC50: 0.0185 mM, suppresses nt only sorbitol accumulation in human erythrocytes
0.0192
2-(4-hydroxy-3-methoxyphenyl)ethanol
Homo sapiens;
-
derived from ginger rhizom, Zingiber officinale, IC50: 0.0192 mM, suppresses sorbitol accumulation in human erythrocytes
0.0265
2-amino-4-oxo-3,4-dihydropteridine-7-carboxylic acid
Homo sapiens;
-
pH and temperature not specified in the publication
0.0251
2-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]-4-phenylbutanoic acid
Homo sapiens;
-
pH and temperature not specified in the publication
0.0012
2-[(4-fluorobenzyl)[(2-fluorophenyl)sulfonyl]amino]-N-[2-(3-fluorophenyl)ethyl]acetamide
Homo sapiens;
P42330
pH 6.6, temperature not specified in the publication
0.4812
3,4-dinitro-2,5-bis(phenylsulfanyl)thiophene
Homo sapiens;
-
-
0.127
3,5-dichlorosalicylic acid
Homo sapiens;
-
ALR2 in 50 mM potassium phosphate (pH 6.2)
53.54
3-(1H-indol-1-yl)propanoic acid
Homo sapiens;
-
pH and temperature not specified in the publication
0.0765
3-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
Homo sapiens;
-
pH 7.0, 37C
0.022
3-(2-phenylthiazole-4-yl)propanoic acid
Homo sapiens;
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.283
3-(4-hydroxy-3-methoxyphenyl)propanol
Homo sapiens;
-
IC50: 0.283 mM
0.1073
3-(4-nitrophenyl)-2-[(phenylsulfonyl)amino]propanoic acid
Homo sapiens;
-
-
0.0019 - 0.014
3-(5-(3-(trifluormethyl)phenyl)thiophene-2-yl)propanoic acid
0.003
3-(5-(3-acetylphenyl)furan-2-yl)propanoic acid
Homo sapiens;
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.016
3-(5-(3-aminophenyl)furan-2-yl)propanoic acid
Homo sapiens;
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.0068
3-(5-(3-methoxyphenyl)furan-2-yl)propanoic acid
Homo sapiens;
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.0054
3-(5-(3-methoxyphenyl)thiophene-2-yl)propanoic acid
Homo sapiens;
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.0057
3-(5-(3-methylphenyl)furan-2-yl)propanoic acid
Homo sapiens;
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.0049
3-(5-(3-methylphenyl)thiophene-2-yl)propanoic acid
Homo sapiens;
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.004
3-(5-(3-methylsulfonyl)phenylfuran-2-yl)propanoic acid
Homo sapiens;
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.00026
3-(5-(3-nitrophenyl)furan-2-yl)propanoic acid
Homo sapiens;
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.00017
3-(5-(3-nitrophenyl)thiophene-2-yl)propanoic acid
Homo sapiens;
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.002
3-(5-(3-trifluormethyl)phenylfuran-2-yl)propanoic acid
Homo sapiens;
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.016
3-(5-phenylfuran-2-yl)propanoic acid
Homo sapiens;
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.0053
3-(5-phenylthiophene-2-yl)propanoic acid
Homo sapiens;
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.031
3-(5-pyridine-2-yl-furan-2-yl)propanoic acid
Homo sapiens;
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.019
3-(5-pyridine-3-yl-furan-2-yl)propanoic acid
Homo sapiens;
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.03108
3-benzyl-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl 4-methylbenzenesulfonate
Homo sapiens;
-
-
0.2808
3-[3,4-dihydroxy-5-(3-methylbut-2-en-1-yl)phenyl]-5,7-dihydroxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
Homo sapiens;
-
pH 7.0, 37C
19.85
3-[3-[(diethylamino)methyl]-1H-indol-1-yl]propanoic acid
Homo sapiens;
-
pH and temperature not specified in the publication
0.197
4-(4-hydroxy-3-methoxyphenyl)-2-butanone
Homo sapiens;
-
IC50: 0.197 mM
0.642
4-(4-hydroxy-3-methoxyphenyl)butanol
Homo sapiens;
-
IC50: 0.642 mM
0.0031
4-(5-(3-methylphenyl)thiophene-2-yl)butanoic acid
Homo sapiens;
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.0064
4-(5-phenylthiophene-2-yl)butanoic acid
Homo sapiens;
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.273
4-hydroxy-3-methoxyphenol
Homo sapiens;
-
IC50: 0.273 mM
0.0244
4-hydroxy-3-methoxyphenyl methanol
Homo sapiens;
-
IC50: 0.0244 mM
0.0041
4-oxo-4-(5-(3-methylphenyl)thiophene-2-yl)butanoic acid
Homo sapiens;
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.0065
4-oxo-4-(5-phenylthiophen-2-yl)butanoic acid
Homo sapiens;
-
in sodium phosphate buffer (100 mM, pH 6.2)
0.0255
4-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]butanoic acid
Homo sapiens;
-
pH and temperature not specified in the publication
0.00119 - 0.00392
4-[3-(5-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidin-6-yl)-1,2,4-oxadiazol-5-yl]butanoic acid
0.1762
4-[5,7-dimethoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol
Homo sapiens;
-
pH 7.0, 37C
0.1306
4-[7-hydroxy-5-methoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol
Homo sapiens;
-
pH 7.0, 37C
0.0853
5-oxo-3-phenyl-5-(quinolin-2-ylamino)pentanoic acid
Homo sapiens;
-
-
0.0117
5-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]pentanoic acid
Homo sapiens;
-
pH and temperature not specified in the publication
0.00402
6-[(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)amino]hexanoic acid
Homo sapiens;
-
pH and temperature not specified in the publication
0.00079
8-lavandulylkaempferol
Homo sapiens;
-
-
0.001
8-methoxy-N-[(1S)-2-methyl-1-(5-phenyl-1H-imidazol-2-yl)propyl]-2H-1-benzopyran-3-carboxamide
Homo sapiens;
-
pH 6.2, 30C
0.000731
8-methoxy-N-[(5-phenyl-1H-imidazol-2-yl)methyl]-2H-1-benzopyran-3-carboxamide
Homo sapiens;
-
pH 6.2, 30C
0.000899
8-methoxy-N-[[5-(4-methoxyphenyl)-1H-imidazol-2-yl]methyl]-2H-1-benzopyran-3-carboxamide
Homo sapiens;
-
pH 6.2, 30C
0.003
bezafibrate
Homo sapiens;
-
noncompetitive, IC50: 0.003 mM, recombinant enzyme
0.0007
butein
Homo sapiens;
-
in 0.1 M sodium phosphate buffer (pH 6.2)
0.00086
ciprofibrate
Homo sapiens;
-
competitive, IC50: 0.00086 mM, recombinant enzyme
0.0012
Clofibric acid
Homo sapiens;
-
noncompetitive, IC50: 0.0012 mM, recombinant enzyme
0.1873
coptisine
Homo sapiens;
-
in 100 mM sodium phosphate buffer (pH 6.2)
0.01 - 0.03
curcumin
0.00045
desmethylanhydroicaritin
Homo sapiens;
-
-
0.0000665 - 0.0013
epalrestat
0.1681
epiberberine
Homo sapiens;
-
in 100 mM sodium phosphate buffer (pH 6.2)
0.00056
fenofibrate
Homo sapiens;
-
competitive, IC50: 0.00056 mM, recombinant enzyme
0.000026
fidarestat
Homo sapiens;
-
pH 7.0, 25C, recom