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Information on EC 1.1.1.209 - 3(or 17)alpha-hydroxysteroid dehydrogenase

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IUBMB Comments
Acts on the 3alpha-hydroxy group of androgens of the 5alpha-androstane series; and also, more slowly, on the 17alpha-hydroxy group of both androgenic and estrogenic substrates (cf. EC 1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase).
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The enzyme appears in viruses and cellular organisms
Synonyms
akr1c21, 3beta- and 17beta-hydroxysteroid dehydrogenase, 3(17)alpha-hydroxysteroid dehydrogenase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
androsterone + NAD(P)+ = 5alpha-androstane-3,17-dione + NAD(P)H + H+
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random binding pattern of substrate, ordered release of product, pro-R-hydrogen atom of NAD(P)H is transferred to the carbonyl site
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