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EC Tree
IUBMB CommentsThe enzyme acts on the hydroxy group of the hydrated derivative of the substrate.
The taxonomic range for the selected organisms is: Borreliella burgdorferi
The enzyme appears in selected viruses and cellular organisms
Synonyms
impdh, imp dehydrogenase, inosine monophosphate dehydrogenase, impdh2, impdh1, inosine 5'-monophosphate dehydrogenase, inosine-5'-monophosphate dehydrogenase, impdh ii, imp dh, inosinate dehydrogenase,
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inosine 5'-monophosphate dehydrogenase
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dehydrogenase, inosinate
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IMP dehydrogenase
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IMP oxidoreductase
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inosinate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
inosine monophosphate dehydrogenase
inosine monophosphate oxidoreductase
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inosine-5'-phosphate dehydrogenase
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inosinic acid dehydrogenase
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Raspberry protein
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Superoxide-inducible protein 12
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IMPDH
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine monophosphate dehydrogenase
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inosine monophosphate dehydrogenase
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IMP:NAD+ oxidoreductase
The enzyme acts on the hydroxy group of the hydrated derivative of the substrate.
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inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
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inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
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?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
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inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
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subdomain of the enzyme is not required for catalytic activity
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inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
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?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH
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subdomain of the enzyme is not required for catalytic activity
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?
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NAD+
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1H-naphtho[2,3-d]imidazol-2-ylmethyl 4-aminobenzoate
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2-[(3-ethyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide
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3-(1H-naphtho[2,3-d]imidazol-2-yl)propyl 4-aminobenzoate
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GMP
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competitive with respect to IMP
methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylate
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N-(4-methoxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
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N-(4-methoxyphenyl)-2-[2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]acetamide
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N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-5,6-dihydro-1H-benzimidazol-1-yl]acetamide
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NAD+
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substrate inhibition at high concentration
P1-(thiazofurin-5'-yl)-P2-(adenosyl-5'-yl)-alpha,beta-methylene diphosphate
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thiazole-4-carboxamide adenine dinucleotide
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uncompetitive with respect to IMP and NAD
xanthosine 5'-phosphate
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competitive with respect to IMP
additional information
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overview
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Mycophenolic acid
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Mycophenolic acid
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uncompetitive with respect to IMP and NAD+
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0.029
inosine 5'-phosphate
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in the presence of 25 mM K+
1.1
NAD+
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in the presence of 25 mM K+
additional information
additional information
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additional information
additional information
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additional information
additional information
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overview
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2.6
inosine 5'-phosphate
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in the presence of 25 mM K+
additional information
additional information
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overview
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0.0016
P1-(thiazofurin-5'-yl)-P2-(adenosyl-5'-yl)-alpha,beta-methylene diphosphate
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additional information
additional information
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0.00022
1H-naphtho[2,3-d]imidazol-2-ylmethyl 4-aminobenzoate
Borreliella burgdorferi
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pH 8.0, 25°C
0.0008
2-[(3-ethyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide
Borreliella burgdorferi
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pH 8.0, 25°C
0.0009
3-(1H-naphtho[2,3-d]imidazol-2-yl)propyl 4-aminobenzoate
Borreliella burgdorferi
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pH 8.0, 25°C
0.0009
methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylate
Borreliella burgdorferi
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pH 8.0, 25°C
0.0017
N-(4-methoxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
Borreliella burgdorferi
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pH 8.0, 25°C
0.0006
N-(4-methoxyphenyl)-2-[2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]acetamide
Borreliella burgdorferi
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pH 8.0, 25°C
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UniProt
brenda
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physiological function
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is a key enzyme in the biosynthesis of purine nucleotides
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43640
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calculated from amino acid composition
additional information
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equilibrium sedimentation results suggest monomeric, dimeric and tetrameric forms and higher order aggregates
44000
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in complex with sulfate, at 2.4 A resolution
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Zhou, X.; Cahoon, M.; Rosa, P.; Hedstrom, L.
Expression, purification, and characterization of inosine 5'-monophosphate dehydrogenase from Borrelia burgdorferi
J. Biol. Chem.
35
21977-21981
1997
Borreliella burgdorferi
brenda
Goldstein, B.M.; Colby, T.D.
IMP dehydrogenase: Structural aspects of inhibitor binding
Curr. Med. Chem.
6
519-536
1999
Borreliella burgdorferi, Cricetulus griseus, Homo sapiens, Streptococcus pyogenes, Tritrichomonas suis
brenda
Hedstrom, L.
IMP dehydrogenase: Mechanism of action and inhibition
Curr. Med. Chem.
6
545-560
1999
Borreliella burgdorferi, Escherichia coli, Eimeria tenella, Homo sapiens, Rattus norvegicus, Tritrichomonas suis
brenda
Pimkin, M.; Markham, G.
Inosine 5-monophosphate dehydrogenase
Adv. Enzymol. Relat. Areas Mol. Biol.
76
1-53
2009
Klebsiella aerogenes, Borreliella burgdorferi, Saccharomyces cerevisiae, Candida albicans, Cricetulus griseus, Cryptosporidium parvum, Escherichia coli, Homo sapiens, Mus musculus, Streptococcus pyogenes, Tritrichomonas suis
brenda
Hedstrom, L.
IMP dehydrogenase: Structure, mechanism, and inhibition
Chem. Rev.
109
2903-2928
2009
Klebsiella aerogenes, Candida albicans, Cricetulus griseus, Escherichia coli, Eimeria tenella, Staphylococcus aureus, Plasmodium falciparum, Pyrococcus horikoshii, Toxoplasma gondii, no activity in Giardia lamblia, no activity in Trichomonas vaginalis, Streptococcus pyogenes (P0C0H6), Homo sapiens (P12268), Homo sapiens (P20839), Leishmania donovani (P21620), Borreliella burgdorferi (P49058), Tritrichomonas suis (P50097), Trypanosoma brucei (P50098), Pneumocystis carinii (Q12658), Cryptosporidium parvum (Q8T6T2)
brenda
Shu, Q.; Nair, V.
Inosine monophosphate dehydrogenase (IMPDH) as a target in drug discovery
Med. Res. Rev.
28
219-232
2008
Borreliella burgdorferi, Cricetulus griseus, Escherichia coli, Leishmania donovani, Mycobacterium tuberculosis, Mus musculus, Rattus norvegicus, Streptococcus pyogenes, Thermotoga maritima, Tritrichomonas suis, Pyrococcus horikoshii OT3, Homo sapiens (P12268), Homo sapiens (P20839)
brenda
Gollapalli, D.R.; Macpherson, I.S.; Liechti, G.; Gorla, S.K.; Goldberg, J.B.; Hedstrom, L.
Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases
Chem. Biol.
17
1084-1091
2010
Borreliella burgdorferi, Escherichia coli, Helicobacter pylori, Streptococcus pyogenes
brenda