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Information on EC 1.1.1.205 - IMP dehydrogenase and Organism(s) Streptococcus pyogenes and UniProt Accession P0C0H6

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     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.205 IMP dehydrogenase
IUBMB Comments
The enzyme acts on the hydroxy group of the hydrated derivative of the substrate.
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This record set is specific for:
Streptococcus pyogenes
UNIPROT: P0C0H6
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The taxonomic range for the selected organisms is: Streptococcus pyogenes
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
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IMP
+
NAD+
+
H2O
=
XMP
+
NADH
+
H+
+
+
=
+
+
Synonyms
impdh, imp dehydrogenase, inosine monophosphate dehydrogenase, impdh2, impdh1, inosine 5'-monophosphate dehydrogenase, inosine-5'-monophosphate dehydrogenase, impdh ii, imp dh, inosinate dehydrogenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
inosine 5'-monophosphate dehydrogenase
-
dehydrogenase, inosinate
-
-
-
-
IMP dehydrogenase
-
-
-
-
IMP oxidoreductase
-
-
-
-
IMPD
-
-
-
-
IMPDH
inosinate dehydrogenase
-
-
-
-
inosine 5'-monophosphate dehydrogenase
inosine monophosphate dehydrogenase
inosine monophosphate oxidoreductase
-
-
-
-
inosine-5'-phosphate dehydrogenase
-
-
-
-
inosinic acid dehydrogenase
-
-
-
-
Raspberry protein
-
-
-
-
SOI12
-
-
-
-
Superoxide-inducible protein 12
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
-
oxidation
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
IMP:NAD+ oxidoreductase
The enzyme acts on the hydroxy group of the hydrated derivative of the substrate.
CAS REGISTRY NUMBER
COMMENTARY hide
9028-93-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
show the reaction diagram
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
xanthosine 5'-phosphate + NADH + H+
show the reaction diagram
-
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6-Chloropurine
irreversible inhibitor
mizobirine 5'-monophosphate
-
Mycophenolic acid
-
ribavirin 5'-monophosphate
-
1H-naphtho[2,3-d]imidazol-2-ylmethyl 4-aminobenzoate
-
-
2-[(3-ethyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide
-
-
3-(1H-naphtho[2,3-d]imidazol-2-yl)propyl 4-aminobenzoate
-
-
methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylate
-
-
mizoribine monophosphate
-
-
Mycophenolic acid
-
-
N-(4-methoxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
-
-
N-(4-methoxyphenyl)-2-[2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]acetamide
-
-
N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-5,6-dihydro-1H-benzimidazol-1-yl]acetamide
-
-
ribavirin monophosphate
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.062
inosine 5'-phosphate
-
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
24
inosine 5'-phosphate
-
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0005
mizoribine monophosphate
-
-
10
Mycophenolic acid
-
-
0.006
ribavirin monophosphate
-
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00055
1H-naphtho[2,3-d]imidazol-2-ylmethyl 4-aminobenzoate
Streptococcus pyogenes
-
pH 8.0, 25°C
0.013
2-[(3-ethyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide
Streptococcus pyogenes
-
pH 8.0, 25°C
0.00086
3-(1H-naphtho[2,3-d]imidazol-2-yl)propyl 4-aminobenzoate
Streptococcus pyogenes
-
pH 8.0, 25°C
0.015
methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylate
Streptococcus pyogenes
-
pH 8.0, 25°C
0.049
N-(4-methoxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
Streptococcus pyogenes
-
pH 8.0, 25°C
0.07
N-(4-methoxyphenyl)-2-[2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]acetamide
Streptococcus pyogenes
-
pH 8.0, 25°C
0.0000054
N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-5,6-dihydro-1H-benzimidazol-1-yl]acetamide
Streptococcus pyogenes
-
pH 8.0, 25°C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
-
is a key enzyme in the biosynthesis of purine nucleotides
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
IMDH_STRPY
493
0
52807
Swiss-Prot
-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
tetramer
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
tetramer structure of IMPDH shows square planar geometry
vapor diffusion method using hanging drops
in complex with inosine 5'-phosphate at 1.9 A resolution
-
in complex with inosine 5'-phosphate, at 1.9 A resolution
-
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E421Q
full enzymatic activity
R406A
no enzymatic activity
Y450A
25% of enzymatic activity
Y450D
no enzymatic activity
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zhang, R.G.; Evans, G.; Rotella, F.J.; Westbrook, E.M.; Beno, D.; Huberman, E; Joachimiak, A.; Collart, F.R.
Characteristics and crystal structure of bacterial inosine-5'-monophosphate dehydrogenase
Biochemistry
38
4691-4700
1999
Streptococcus pyogenes (P0C0H6), Streptococcus pyogenes
Manually annotated by BRENDA team
Goldstein, B.M.; Colby, T.D.
IMP dehydrogenase: Structural aspects of inhibitor binding
Curr. Med. Chem.
6
519-536
1999
Borreliella burgdorferi, Cricetulus griseus, Homo sapiens, Streptococcus pyogenes, Tritrichomonas suis
Manually annotated by BRENDA team
Pimkin, M.; Markham, G.
Inosine 5-monophosphate dehydrogenase
Adv. Enzymol. Relat. Areas Mol. Biol.
76
1-53
2009
Klebsiella aerogenes, Borreliella burgdorferi, Saccharomyces cerevisiae, Candida albicans, Cricetulus griseus, Cryptosporidium parvum, Escherichia coli, Homo sapiens, Mus musculus, Streptococcus pyogenes, Tritrichomonas suis
Manually annotated by BRENDA team
Hedstrom, L.
IMP dehydrogenase: Structure, mechanism, and inhibition
Chem. Rev.
109
2903-2928
2009
Klebsiella aerogenes, Candida albicans, Cricetulus griseus, Escherichia coli, Eimeria tenella, Staphylococcus aureus, Plasmodium falciparum, Pyrococcus horikoshii, Toxoplasma gondii, no activity in Giardia lamblia, no activity in Trichomonas vaginalis, Streptococcus pyogenes (P0C0H6), Homo sapiens (P12268), Homo sapiens (P20839), Leishmania donovani (P21620), Borreliella burgdorferi (P49058), Tritrichomonas suis (P50097), Trypanosoma brucei (P50098), Pneumocystis carinii (Q12658), Cryptosporidium parvum (Q8T6T2)
Manually annotated by BRENDA team
Shu, Q.; Nair, V.
Inosine monophosphate dehydrogenase (IMPDH) as a target in drug discovery
Med. Res. Rev.
28
219-232
2008
Borreliella burgdorferi, Cricetulus griseus, Escherichia coli, Leishmania donovani, Mycobacterium tuberculosis, Mus musculus, Rattus norvegicus, Streptococcus pyogenes, Thermotoga maritima, Tritrichomonas suis, Pyrococcus horikoshii OT3, Homo sapiens (P12268), Homo sapiens (P20839)
Manually annotated by BRENDA team
Gollapalli, D.R.; Macpherson, I.S.; Liechti, G.; Gorla, S.K.; Goldberg, J.B.; Hedstrom, L.
Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases
Chem. Biol.
17
1084-1091
2010
Borreliella burgdorferi, Escherichia coli, Helicobacter pylori, Streptococcus pyogenes
Manually annotated by BRENDA team