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Synonyms
impdh, imp dehydrogenase, inosine monophosphate dehydrogenase, impdh2, impdh1, inosine 5'-monophosphate dehydrogenase, inosine-5'-monophosphate dehydrogenase, impdh ii, imp dh, inosinate dehydrogenase,
more
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dehydrogenase, inosinate
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EC 1.2.1.14
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formerly
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IMP:NAD oxidoreductase
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IMP:NAD+ oxidoreductase
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inosine 5' monophosphate dehydrogenase
inosine 5'-monophosphate dehydrogenase
inosine 5'-monophosphate dehydrogenase 2
inosine 5'-phosphate dehydrogenase
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inosine 5-monophosphate dehydrogenase
inosine 5-monophosphate dehydrogenase 2
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inosine 5-monophosphate dehydrogenase type I
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inosine 5 -monophosphate dehydrogenase
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inosine 5-monophosphate dehydrogenase 2
inosine monophosphate dehydrogenase
inosine monophosphate dehydrogenase-1
inosine monophosphate dehydrogenase-2
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inosine monophosphate oxidoreductase
inosine-5'-monophosphate dehydrogenase
inosine-5'-phosphate dehydrogenase
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inosine-5-monophosphate dehydrogenase
inosinic acid 5-monophosphate dehydrogenase
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inosinic acid dehydrogenase
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Raspberry protein
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Superoxide-inducible protein 12
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type 1 inosine monophosphate
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type 2 inosine monophosphate dehydrogenase
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class I IMPDH

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class II IMPDH

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guaB

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guaB2

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IMP dehydrogenase

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IMP DH

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IMP oxidoreductase

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IMPDH

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IMPDH
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667473, 667935, 667937, 667938, 667965, 667966, 667976, 667980, 668351, 669476, 669807, 670881, 701583, 703272, 706817, 761825
IMPDH II

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IMPDH1

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IMPDH2

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IMPDHA

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isoform
IMPDHab

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IMPDHkp

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IMPDHlpp

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inosinate dehydrogenase

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inosinate dehydrogenase
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inosine 5' monophosphate dehydrogenase

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inosine 5' monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase

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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase
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inosine 5'-monophosphate dehydrogenase 2

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inosine 5'-monophosphate dehydrogenase 2
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inosine 5'-monophosphate dehydrogenase 2
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inosine 5-monophosphate dehydrogenase

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inosine 5-monophosphate dehydrogenase
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inosine 5-monophosphate dehydrogenase
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inosine 5-monophosphate dehydrogenase
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inosine 5-monophosphate dehydrogenase
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inosine 5-monophosphate dehydrogenase
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inosine 5-monophosphate dehydrogenase
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inosine 5-monophosphate dehydrogenase
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inosine 5-monophosphate dehydrogenase
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inosine 5-monophosphate dehydrogenase
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inosine 5-monophosphate dehydrogenase
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inosine 5-monophosphate dehydrogenase
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inosine 5-monophosphate dehydrogenase 2

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inosine 5-monophosphate dehydrogenase 2
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inosine monophosphate dehydrogenase

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inosine monophosphate dehydrogenase
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inosine monophosphate dehydrogenase
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inosine monophosphate dehydrogenase
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inosine monophosphate dehydrogenase
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inosine monophosphate dehydrogenase
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inosine monophosphate dehydrogenase
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inosine monophosphate dehydrogenase
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inosine monophosphate dehydrogenase
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inosine monophosphate dehydrogenase
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667935, 667937, 667938, 667976, 667980, 669476, 669807, 670881, 703272, 706815, 761825
inosine monophosphate dehydrogenase
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inosine monophosphate dehydrogenase
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inosine monophosphate dehydrogenase
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inosine monophosphate dehydrogenase
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inosine monophosphate dehydrogenase
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inosine monophosphate dehydrogenase
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inosine monophosphate dehydrogenase
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inosine monophosphate dehydrogenase
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inosine monophosphate dehydrogenase
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inosine monophosphate dehydrogenase
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inosine monophosphate dehydrogenase
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inosine monophosphate dehydrogenase-1

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inosine monophosphate dehydrogenase-1
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inosine monophosphate oxidoreductase

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inosine monophosphate oxidoreductase
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inosine-5'-monophosphate dehydrogenase

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inosine-5'-monophosphate dehydrogenase
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inosine-5'-monophosphate dehydrogenase
Q81W29
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inosine-5'-monophosphate dehydrogenase
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inosine-5'-monophosphate dehydrogenase
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inosine-5'-monophosphate dehydrogenase
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inosine-5'-monophosphate dehydrogenase
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inosine-5'-monophosphate dehydrogenase
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inosine-5'-monophosphate dehydrogenase
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inosine-5'-monophosphate dehydrogenase
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inosine-5'-monophosphate dehydrogenase
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inosine-5'-monophosphate dehydrogenase
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inosine-5'-monophosphate dehydrogenase
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inosine-5'-monophosphate dehydrogenase
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inosine-5'-monophosphate dehydrogenase
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inosine-5'-monophosphate dehydrogenase
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inosine-5'-monophosphate dehydrogenase
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inosine-5'-monophosphate dehydrogenase
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inosine-5'-monophosphate dehydrogenase
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inosine-5'-monophosphate dehydrogenase
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inosine-5-monophosphate dehydrogenase

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inosine-5-monophosphate dehydrogenase
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lpg1723

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Rv3411c

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IMP + NAD+ + H2O = XMP + NADH + H+
IMP + NAD+ + H2O = XMP + NADH + H+

reaction mechanism
IMP + NAD+ + H2O = XMP + NADH + H+
ordered sequential mechanism
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IMP + NAD+ + H2O = XMP + NADH + H+
ordered sequential mechanism
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IMP + NAD+ + H2O = XMP + NADH + H+
ordered sequential mechanism
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IMP + NAD+ + H2O = XMP + NADH + H+
enzyme acts on the hydroxyl group of the hydrated derivative of the substrate, ordered bi-bi mechanism
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IMP + NAD+ + H2O = XMP + NADH + H+
enzyme acts on the hydroxyl group of the hydrated derivative of the substrate, ordered bi-bi mechanism
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IMP + NAD+ + H2O = XMP + NADH + H+
sequential addition of IMP, NAD+ and K+
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IMP + NAD+ + H2O = XMP + NADH + H+
IMP and K+ can bind randomly to the free enzyme, while NAD+ does not react unless K+ or both K+ and IMP are present on the enzyme
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IMP + NAD+ + H2O = XMP + NADH + H+
IMP binds first, followed by NAD+, NADH dissociates from the ternary complex first, then XMP is released
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IMP + NAD+ + H2O = XMP + NADH + H+
mechanism is partially random
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IMP + NAD+ + H2O = XMP + NADH + H+
IMP binds first, XMP is released last
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IMP + NAD+ + H2O = XMP + NADH + H+
Arg418 is involved in the reaction mechanism as catalytic base
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IMP + NAD+ + H2O = XMP + NADH + H+
covalent enzyme reaction intermediate, hydrolysis of enzyme-XMP is rate-limiting and requires the adoption of the closed conformation, Arg418 is involved in the reaction mechanism as catalytic base, Thr321 is involved in both hydride transfer and hydrolysis
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IMP + NAD+ + H2O = XMP + NADH + H+
reaction and kinetic mechanism, an Arg residue is involved in catalysis as general base
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IMP + NAD+ + H2O = XMP + NADH + H+
reaction and kinetic mechanism, an Arg residue is involved in catalysis as general base, Cys319-linked covalent enzyme intermediate E-XMP
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IMP + NAD+ + H2O = XMP + NADH + H+
substrate binding and catalytic reaction mechanism, Cys319 is the catalytic residue, NAD+ promotes the nucleophilic attack of Cys319 on IMP
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IMP + NAD+ + H2O = XMP + NADH + H+
a steady-state ordered Bi Bi kinetic mechanism in which IMP binds first followed by NAD+, and product release is ordered. Hydride transfer appears not to be rate-limiting. The pH-rate profile indicates one deprotonated group essential for catalysis
IMP + NAD+ + H2O = XMP + NADH + H+
reaction in two steps via covalent interemediate state, the catalytic residue is Cys334
IMP + NAD+ + H2O = XMP + NADH + H+
the enzymatic mechanism of IMPDH consists two steps, a dehydrogenase and a hydrolase reaction. Upon binding of IMP and NAD+ cofactor, a thioimidate enzyme-substrate adduct, E-XMP*, is formed via a covalent bond to the catalytic C341 with concurrent production of NADH. Hydride transfer occurs to the pro-S position with the cofactor in the anti-conformation. The cofactor is released and an active site mobile flap moves into the NAD+ site and facilitates E-XMP* hydrolysis with a conserved R443 acting as a general base. The enzyme has two distinct conformations, an open form for the dehydrogenase reaction and a closed form for E-XMP* hydrolysis
IMP + NAD+ + H2O = XMP + NADH + H+
the IMPDH reaction involves two chemical transformations. First, the catalytic Cys attacks IMP, and hydride is transferred to NAD to form the covalent intermediate E-XMP*. In the second step, E-XMP* is hydrolyzed to produce XMP
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IMP + NAD+ + H2O = XMP + NADH + H+
the IMPDH reaction involves two chemical transformations. First, the catalytic Cys attacks IMP, and hydride is transferred to NAD to form the covalent intermediate E-XMP*. In the second step, E-XMP* is hydrolyzed to produce XMP
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IMP + NAD+ + H2O = XMP + NADH + H+
the IMPDH reaction involves two chemical transformations. First, the catalytic Cys attacks IMP, and hydride is transferred to NAD to form the covalent intermediate E-XMP*. In the second step, E-XMP* is hydrolyzed to produce XMP
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IMP + NAD+ + H2O = XMP + NADH + H+
the IMPDH reaction involves two chemical transformations. First, the catalytic Cys attacks IMP, and hydride is transferred to NAD to form the covalent intermediate E-XMP*. In the second step, E-XMP* is hydrolyzed to produce XMP
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IMP + NAD+ + H2O = XMP + NADH + H+
the enzymatic mechanism of IMPDH consists two steps, a dehydrogenase and a hydrolase reaction. Upon binding of IMP and NAD+ cofactor, a thioimidate enzyme-substrate adduct, E-XMP*, is formed via a covalent bond to the catalytic C341 with concurrent production of NADH. Hydride transfer occurs to the pro-S position with the cofactor in the anti-conformation. The cofactor is released and an active site mobile flap moves into the NAD+ site and facilitates E-XMP* hydrolysis with a conserved R443 acting as a general base. The enzyme has two distinct conformations, an open form for the dehydrogenase reaction and a closed form for E-XMP* hydrolysis
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IMP + NAD+ + H2O = XMP + NADH + H+
a steady-state ordered Bi Bi kinetic mechanism in which IMP binds first followed by NAD+, and product release is ordered. Hydride transfer appears not to be rate-limiting. The pH-rate profile indicates one deprotonated group essential for catalysis
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IMP + NAD+ + H2O = XMP + NADH + H+
reaction in two steps via covalent interemediate state, the catalytic residue is Cys334
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IMP + NAD+ + H2O = XMP + NADH + H+
reaction mechanism
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IMP + NAD+ + H2O = XMP + NADH + H+
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