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Information on EC 1.1.1.202 - 1,3-propanediol dehydrogenase
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EC Tree
1.1.1.202 1,3-propanediol dehydrogenaseSpecify your search results
Word Map
- 1.1.1.202
- pneumoniae
- klebsiella
- dehydratase
- synthesis
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fed-batch
- butyricum
- freundii
- citrobacter
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3-hydroxypropionic
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dissimilation
- 1,2-propanediol
- pasteurianum
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eutropha
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biodiesel
- reuteri
- industry
The enzyme appears in viruses and cellular organisms
Synonyms
1,3-propanediol oxidoreductase, 1,3-propanediol dehydrogenase, 1,3-pd oxidoreductase, lr_1734, lr_0030, 1,3-pd dehydrogenase, 1,3-propanediol-oxidoreductase, nadh-dependent 1,3-propanediol oxidoreductase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
1,3-PD dehydrogenase
1,3-PD oxidoreductase
1,3-PD:NAD+ oxidoreductase
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1,3-PDDH
1,3-Pdiol dehydrogenase
1,3-propanediol dehydrogenase
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1,3-propanediol oxidoreductase
1,3-propanediol-oxidoreductase
1,3-propanediol-oxydoreductase
1,3-propanediol:NAD oxidoreductase
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3-hydroxypropionaldehyde reductase
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ADH3
dehydrogenase, 1,3-propanediol
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DhaT
NADH-dependent 1,3-PD dehydrogenase
NADH-dependent 1,3-propanediol oxidoreductase
PDOR
YqhD
1,3-propanediol oxidoreductase
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1,3-propanediol oxidoreductase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
propane-1,3-diol + NAD+ = 3-hydroxypropanal + NADH + H+
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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redox reaction
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reduction
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SYSTEMATIC NAME
IUBMB Comments
propane-1,3-diol:NAD+ 1-oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY
81611-70-3
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acetone + NADH + H+
?
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25.3% activity compared to propionaldehyde
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?
hydroxyacetone + NADH + H+
?
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30.6% activity compared to propionaldehyde
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?
propane-1,3-diol + NADP+
3-hydroxypropanal + NADPH + H+
NADP+ is not substrate for wild-type, but for mutant D41G
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r
1,3-propanediol + NAD+
3-hydroxypropanal + NADH
activity with 1,3-propanediol is highly dependent on the presence of Ni2+
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?
1,3-propanediol + NAD+
3-hydroxypropanal + NADH
activity with 1,3-propanediol is highly dependent on the presence of Ni2+
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?
1,4-butanediol + NAD+
4-hydroxybutanal + NADH + H+
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r
3-hydroxypropanal + NADH
propane-1,3-diol + NAD+
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overexpression of PDOR does not affect the concentration of propane-1,3-diol, but it enhances the molar yield from 50.6 to 64.0% and reduces the concentration of by-products, among them, the concentrations of lactic acid, ethanol and succinic acid are decreased by 51.8, 50.6 and 47.4%, respectively. Activity of recombinant PDOR is 44fold higher than those of the wild-type. PDOR overexpression leads to a slower cell growth and lower productivity, and during the fed-batch fermentation in 3.7 l bioreactor, a growth stagnation is observed
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?
3-hydroxypropanal + NADH
propane-1,3-diol + NAD+
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overexpression of PDOR does not affect the concentration of propane-1,3-diol, but it enhances the molar yield from 50.6 to 64.0% and reduces the concentration of by-products, among them, the concentrations of lactic acid, ethanol and succinic acid are decreased by 51.8, 50.6 and 47.4%, respectively. Activity of recombinant PDOR is 44fold higher than those of the wild-type. PDOR overexpression leads to a slower cell growth and lower productivity, and during the fed-batch fermentation in 3.7 l bioreactor, a growth stagnation is observed
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?
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
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r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
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r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
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r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
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r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
part of the conversion of glycerol to 1,3-propanediol, not the limiting step
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r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
3-hydroxypropionaldehyde is an inhibitory intermediary metabolite in the 1,3-propanediol synthesis pathway during fermentation of raw material required for the synthesis of polytrimethylene terephthalate and other polyester fibers, accumulation of 3-hydroxypropanal in broth causes an irreversible cessation of the fermentation process
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r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
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a key enzyme in the reductive pathway of anaerobic glycerol dissimilation converting glycerol to 1,3-propanediol in the human pathogen Klebsiella pneumoniae
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r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
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activity of PDOR in KG1 (pUC18K-dhaT) is 44fold higher than that of the wild-type strain. In the resting cell system, overexpression of 1,3-propanediol oxidoreductase leads to faster glycerol conversion and propane-1,3-diol production. After a 12 h conversion process, it improves the yield of propane-1,3-diol by 20.4% and enhances the conversion ratio of glycerol into propane-1,3-diol from 50.8% to 59.8%
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?
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
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in the cell exponential growth phase, the reaction catalyzed by 1,3-propanediol oxidoreductase is the rate limiting step in 1,3-propanediol production
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?
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
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level of PDOR activity of Klebsiella pneumoniae/pETPkan-dhaT (1.64 U/mg) shows an increase of 0.9fold in PDOR activity with respect to the wild-type Klebsiella pneumoniae (0.85 U/mg). The recombinant strain Klebsiella pneumoniae/pETPkan-dhaT improves propane-1,3-diol production by 16.5% with respect to the wild-type strain
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?
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
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overexpression of PDOR increases activity by 3.2fold, enzyme activity ratio of PDOR/GDHt (glycerol dehydratase) also is increased. 3-hydroxypropanal accumulation is successfully decreased and the risk of fermentation cease is reduced at the same time by overexpression of PDOR and GDH (glycerol dehydrogenase)
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?
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
under physiological conditions, DhaT mostly catalyzes the forward reaction
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r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
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r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
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r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
under physiological conditions, DhaT mostly catalyzes the forward reaction
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r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
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r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
3-hydroxypropionaldehyde is an inhibitory intermediary metabolite in the 1,3-propanediol synthesis pathway during fermentation of raw material required for the synthesis of polytrimethylene terephthalate and other polyester fibers, accumulation of 3-hydroxypropanal in broth causes an irreversible cessation of the fermentation process
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r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
reduction of the aldehyde is the preferred reaction
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r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
reduction of the aldehyde is the preferred reaction, 3-hydroxypropanal is the preferred substrate
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r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
reduction of the aldehyde is the preferred reaction
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r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
reduction of the aldehyde is the preferred reaction, 3-hydroxypropanal is the preferred substrate
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r
3-hydroxypropanal + NADPH + H+
propane-1,3-diol + NADP+
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improvement of propane-1,3-diol production by a novel propane-1,3-diol operon of three genes (dhaB1 and dhaB2 from Clostridium butyricum and YqhD from Escherichia coli) tandemly arrayed under the control of a constitutive, temperature-sensitive promoter in the vector pBV220 for heterologous expression in Escherichia coli
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?
3-hydroxypropanal + NADPH + H+
propane-1,3-diol + NADP+
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the Escherichia coli yqhD homolog can replace the function of DhaT in the Klebsiella pneumoniae AK mutant strain defective in 1,3-PD oxidoreductase activity (DhaT). The yqhD homolog restores propane-1,3-diol production and 1,3-PD oxidoreductase activity. Level of propane-1,3-diol production during batch fermentation in the recombinant strain is comparable to that of the parent strain
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?
3-hydroxypropanal + NADPH + H+
propane-1,3-diol + NADP+
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improvement of propane-1,3-diol production by a novel propane-1,3-diol operon of three genes (dhaB1 and dhaB2 from Clostridium butyricum and YqhD from Escherichia coli) tandemly arrayed under the control of a constitutive, temperature-sensitive promoter in the vector pBV220 for heterologous expression in Escherichia coli
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?
3-hydroxypropanal + NADPH + H+
propane-1,3-diol + NADP+
NADPH is not substrate for wild-type, but for mutant D41G
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r
3-hydroxypropionaldehyde + NADH
propane-1,3-diol + NAD+
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recombinant mutant Clostridium acetobutylicum strain DG1(pSPD5) expressing the enzyme from an introduced plasmid
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?
3-hydroxypropionaldehyde + NADH
propane-1,3-diol + NAD+
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recombinant mutant Clostridium acetobutylicum strain DG1(pSPD5) expressing the enzyme from an introduced plasmid
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?
3-hydroxypropionaldehyde + NADH + H+
propane-1,3-diol + NAD+
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the enzyme is important in vivo for convertion of glycerol into propane-1,3-diol as second step after dehydration of glycerol by coenzyme B12-dependent glycerol dehydratase
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r
formaldehyde + NADH + H+