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(NADH)-linked 1,3-PD oxidoreductase
-
-
1,3-PD:NAD+ oxidoreductase
-
-
-
-
1,3-propanediol dehydrogenase
-
-
-
-
1,3-propanediol oxidoreductase
1,3-propanediol-oxidoreductase
1,3-propanediol-oxydoreductase
1,3-propanediol:NAD oxidoreductase
-
-
-
-
3-hydroxypropionaldehyde reductase
-
-
-
-
dehydrogenase, 1,3-propanediol
-
-
-
-
NADH-dependent 1,3-PD dehydrogenase
NADH-dependent 1,3-propanediol oxidoreductase
NADH-linked 1,3-propanediol oxidoreductase
-
-
1,3-PD dehydrogenase

-
-
1,3-PD dehydrogenase
-
-
-
1,3-PD oxidoreductase

-
-
1,3-PD oxidoreductase
-
-
1,3-PD oxidoreductase
-
-
-
1,3-PD oxidoreductase
-
-
-
1,3-PDDH

-
-
1,3-Pdiol dehydrogenase

-
-
1,3-Pdiol dehydrogenase
-
-
-
1,3-propanediol oxidoreductase

-
-
-
-
1,3-propanediol oxidoreductase
-
1,3-propanediol oxidoreductase
-
-
1,3-propanediol oxidoreductase
-
-
-
1,3-propanediol oxidoreductase
-
-
1,3-propanediol oxidoreductase
-
1,3-propanediol oxidoreductase
-
1,3-propanediol oxidoreductase
-
-
-
1,3-propanediol oxidoreductase
-
-
1,3-propanediol oxidoreductase
-
-
-
1,3-propanediol oxidoreductase
-
-
-
1,3-propanediol-oxidoreductase

-
-
1,3-propanediol-oxidoreductase
-
-
-
1,3-propanediol-oxydoreductase

-
-
1,3-propanediol-oxydoreductase
-
-
-
1,3-propanediol-oxydoreductase
-
-
1,3-propanediol-oxydoreductase
-
-
-
1,3-propanediol-oxydoreductase
-
-
1,3-propanediol-oxydoreductase
-
-
1,3-propanediol-oxydoreductase
-
-
1,3-propanediol-oxydoreductase
-
-
-
1,3-propanediol-oxydoreductase
-
-
1,3-propanediol-oxydoreductase
-
-
1,3-propanediol-oxydoreductase
-
-
1,3-propanediol-oxydoreductase
-
-
1,3-propanediol-oxydoreductase
-
-
ADH3

-
DhaT

-
-
NADH-dependent 1,3-PD dehydrogenase

-
-
NADH-dependent 1,3-PD dehydrogenase
-
-
-
NADH-dependent 1,3-propanediol oxidoreductase

-
-
NADH-dependent 1,3-propanediol oxidoreductase
-
-
-
PDOR

-
-
YqhD

-
-
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1,2-propanediol + NAD+
2-hydroxypropanal + NADH
1,2-propylene glycol + NAD+
? + NADH + H+
1,3-propanediol + NAD+
3-hydroxypropanal + NADH
1,3-propanediol + NAD+
3-hydroxypropanal + NADH + H+
-
-
-
?
1,4-butanediol + NAD+
4-hydroxybutanal + NADH
1,4-butanediol + NAD+
4-hydroxybutanal + NADH + H+
1-butanol + NAD+
1-butanal + NADH + H+
-
-
-
r
1-butanol + NAD+
NADH + butanal
1-butyl alcohol + NAD+
1-butanal + NADH + H+
1-propanol + NAD+
1-propanal + NADH + H+
-
-
-
r
1-propanol + NAD+
NADH + propanal
1-propanol + NAD+
propanal + NADH + H+
2,3-butanediol + NAD+
? + NADH
-
-
-
-
r
2-butanol + NAD+
NADH + butanone
3-hydroxypropanal + NADH
propane-1,3-diol + NAD+
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
3-hydroxypropanal + NADPH + H+
propane-1,3-diol + NADP+
3-hydroxypropionaldehyde + NADH
propane-1,3-diol + NAD+
3-hydroxypropionaldehyde + NADH + H+
propane-1,3-diol + NAD+
acetaldehyde + NADH + H+
ethanol + NAD+
acetone + NADH + H+
?
-
25.3% activity compared to propionaldehyde
-
-
?
acetone + NADH + H+
? + NAD+
-
-
-
r
butyraldehyde + NADH + H+
butan-1-ol + NAD+
-
-
-
?
dihydroxyacetone + NADH + H+
? + NAD+
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
ethanol + NAD+
NADH + ethanal
ethylene glycol + NAD+
NADH + ?
-
-
-
-
r
formaldehyde + NADH + H+
methanol + NAD+
glyceraldehyde + NADH + H+
? + NAD+
-
-
-
r
glycerol + NAD+
dihydroxyacetone + NADH + H+
glycerol + NAD+
glyceraldehyde + NADH + H+
glycerol + NADH
propane-1,3-diol + NAD+
hydroxyacetone + NADH + H+
?
-
30.6% activity compared to propionaldehyde
-
-
?
hydroxyacetone + NADH + H+
? + NAD+
-
-
-
r
propane-1,2-diol + NAD+
2-hydroxypropanal + NADH
-
-
-
-
r
propane-1,2-diol + NAD+
2-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
3-hydroxypropanal + NADH
propane-1,3-diol + NAD+
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+ + H+
3-hydroxypropanal + NADH
-
-
-
?
propane-1,3-diol + NADP+
3-hydroxypropanal + NADPH + H+
NADP+ is not substrate for wild-type, but for mutant D41G
-
-
r
propionaldehyde + NADH + H+
propan-1-ol + NAD+
valeraldehyde + NADH + H+
pentan-1-ol + NAD+
-
-
-
?
additional information
?
-
1,2-propanediol + NAD+

2-hydroxypropanal + NADH
-
-
-
?
1,2-propanediol + NAD+
2-hydroxypropanal + NADH
-
-
-
?
1,2-propylene glycol + NAD+

? + NADH + H+
-
-
-
-
r
1,2-propylene glycol + NAD+
? + NADH + H+
-
-
-
-
r
1,2-propylene glycol + NAD+
? + NADH + H+
-
-
-
-
r
1,2-propylene glycol + NAD+
? + NADH + H+
-
-
-
-
r
1,2-propylene glycol + NAD+
? + NADH + H+
-
-
-
-
r
1,2-propylene glycol + NAD+
? + NADH + H+
-
-
-
-
r
1,2-propylene glycol + NAD+
? + NADH + H+
-
-
-
-
r
1,2-propylene glycol + NAD+
? + NADH + H+
-
-
-
-
r
1,2-propylene glycol + NAD+
? + NADH + H+
-
-
-
-
r
1,2-propylene glycol + NAD+
? + NADH + H+
-
-
-
-
r
1,2-propylene glycol + NAD+
? + NADH + H+
-
-
-
-
r
1,2-propylene glycol + NAD+
? + NADH + H+
-
-
-
-
r
1,3-propanediol + NAD+

3-hydroxypropanal + NADH
activity with 1,3-propanediol is highly dependent on the presence of Ni2+
-
-
?
1,3-propanediol + NAD+
3-hydroxypropanal + NADH
activity with 1,3-propanediol is highly dependent on the presence of Ni2+
-
-
?
1,4-butanediol + NAD+

4-hydroxybutanal + NADH
-
-
-
-
r
1,4-butanediol + NAD+
4-hydroxybutanal + NADH
-
-
-
-
?
1,4-butanediol + NAD+
4-hydroxybutanal + NADH
-
-
-
-
?
1,4-butanediol + NAD+

4-hydroxybutanal + NADH + H+
-
-
-
-
r
1,4-butanediol + NAD+
4-hydroxybutanal + NADH + H+
-
-
-
-
r
1,4-butanediol + NAD+
4-hydroxybutanal + NADH + H+
-
-
-
-
r
1,4-butanediol + NAD+
4-hydroxybutanal + NADH + H+
-
-
-
-
r
1,4-butanediol + NAD+
4-hydroxybutanal + NADH + H+
-
-
-
-
r
1,4-butanediol + NAD+
4-hydroxybutanal + NADH + H+
-
-
-
-
r
1,4-butanediol + NAD+
4-hydroxybutanal + NADH + H+
-
-
-
-
r
1,4-butanediol + NAD+
4-hydroxybutanal + NADH + H+
-
-
-
r
1,4-butanediol + NAD+
4-hydroxybutanal + NADH + H+
-
-
-
-
r
1,4-butanediol + NAD+
4-hydroxybutanal + NADH + H+
-
-
-
-
r
1,4-butanediol + NAD+
4-hydroxybutanal + NADH + H+
-
-
-
-
r
1-butanol + NAD+

NADH + butanal
-
-
-
-
r
1-butanol + NAD+
NADH + butanal
-
-
-
-
?
1-butanol + NAD+
NADH + butanal
-
-
-
-
?
1-butyl alcohol + NAD+

1-butanal + NADH + H+
-
-
-
-
r
1-butyl alcohol + NAD+
1-butanal + NADH + H+
-
-
-
-
r
1-butyl alcohol + NAD+
1-butanal + NADH + H+
-
-
-
-
r
1-butyl alcohol + NAD+
1-butanal + NADH + H+
-
-
-
-
r
1-butyl alcohol + NAD+
1-butanal + NADH + H+
-
-
-
-
r
1-butyl alcohol + NAD+
1-butanal + NADH + H+
-
-
-
-
r
1-butyl alcohol + NAD+
1-butanal + NADH + H+
-
-
-
-
r
1-butyl alcohol + NAD+
1-butanal + NADH + H+
-
-
-
-
r
1-butyl alcohol + NAD+
1-butanal + NADH + H+
-
-
-
-
r
1-butyl alcohol + NAD+
1-butanal + NADH + H+
-
-
-
-
r
1-propanol + NAD+

NADH + propanal
-
-
-
-
r
1-propanol + NAD+
NADH + propanal
-
-
-
-
?
1-propanol + NAD+
NADH + propanal
-
-
-
-
?
1-propanol + NAD+
NADH + propanal
-
-
-
-
?
1-propanol + NAD+
NADH + propanal
-
-
-
-
?
1-propanol + NAD+

propanal + NADH + H+
-
-
-
-
r
1-propanol + NAD+
propanal + NADH + H+
-
-
-
-
r
1-propanol + NAD+
propanal + NADH + H+
-
-
-
-
r
1-propanol + NAD+
propanal + NADH + H+
-
-
-
-
r
1-propanol + NAD+
propanal + NADH + H+
-
-
-
-
r
1-propanol + NAD+
propanal + NADH + H+
-
-
-
-
r
1-propanol + NAD+
propanal + NADH + H+
-
-
-
-
r
1-propanol + NAD+
propanal + NADH + H+
-
-
-
-
r
1-propanol + NAD+
propanal + NADH + H+
-
-
-
-
r
1-propanol + NAD+
propanal + NADH + H+
-
-
-
-
r
1-propanol + NAD+
propanal + NADH + H+
-
-
-
-
r
1-propanol + NAD+
propanal + NADH + H+
-
-
-
-
r
1-propanol + NAD+
propanal + NADH + H+
-
-
-
-
r
2-butanol + NAD+

NADH + butanone
-
-
-
-
?
2-butanol + NAD+
NADH + butanone
-
-
-
-
?
2-butanol + NAD+
NADH + butanone
-
-
-
-
?
3-hydroxypropanal + NADH

propane-1,3-diol + NAD+
-
overexpression of PDOR does not affect the concentration of propane-1,3-diol, but it enhances the molar yield from 50.6 to 64.0% and reduces the concentration of by-products, among them, the concentrations of lactic acid, ethanol and succinic acid are decreased by 51.8, 50.6 and 47.4%, respectively. Activity of recombinant PDOR is 44fold higher than those of the wild-type. PDOR overexpression leads to a slower cell growth and lower productivity, and during the fed-batch fermentation in 3.7 l bioreactor, a growth stagnation is observed
-
-
?
3-hydroxypropanal + NADH
propane-1,3-diol + NAD+
-
overexpression of PDOR does not affect the concentration of propane-1,3-diol, but it enhances the molar yield from 50.6 to 64.0% and reduces the concentration of by-products, among them, the concentrations of lactic acid, ethanol and succinic acid are decreased by 51.8, 50.6 and 47.4%, respectively. Activity of recombinant PDOR is 44fold higher than those of the wild-type. PDOR overexpression leads to a slower cell growth and lower productivity, and during the fed-batch fermentation in 3.7 l bioreactor, a growth stagnation is observed
-
-
?
3-hydroxypropanal + NADH + H+

propane-1,3-diol + NAD+
-
-
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
-
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
-
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
-
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
-
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
-
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
-
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
-
-
-
?
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
-
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
-
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
-
-
?
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
part of the conversion of glycerol to 1,3-propanediol, not the limiting step
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
3-hydroxypropionaldehyde is an inhibitory intermediary metabolite in the 1,3-propanediol synthesis pathway during fermentation of raw material required for the synthesis of polytrimethylene terephthalate and other polyester fibers, accumulation of 3-hydroxypropanal in broth causes an irreversible cessation of the fermentation process
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
a key enzyme in the reductive pathway of anaerobic glycerol dissimilation converting glycerol to 1,3-propanediol in the human pathogen Klebsiella pneumoniae
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
activity of PDOR in KG1 (pUC18K-dhaT) is 44fold higher than that of the wild-type strain. In the resting cell system, overexpression of 1,3-propanediol oxidoreductase leads to faster glycerol conversion and propane-1,3-diol production. After a 12 h conversion process, it improves the yield of propane-1,3-diol by 20.4% and enhances the conversion ratio of glycerol into propane-1,3-diol from 50.8% to 59.8%
-
-
?
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
in the cell exponential growth phase, the reaction catalyzed by 1,3-propanediol oxidoreductase is the rate limiting step in 1,3-propanediol production
-
-
?
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
level of PDOR activity of Klebsiella pneumoniae/pETPkan-dhaT (1.64 U/mg) shows an increase of 0.9fold in PDOR activity with respect to the wild-type Klebsiella pneumoniae (0.85 U/mg). The recombinant strain Klebsiella pneumoniae/pETPkan-dhaT improves propane-1,3-diol production by 16.5% with respect to the wild-type strain
-
-
?
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
overexpression of PDOR increases activity by 3.2fold, enzyme activity ratio of PDOR/GDHt (glycerol dehydratase) also is increased. 3-hydroxypropanal accumulation is successfully decreased and the risk of fermentation cease is reduced at the same time by overexpression of PDOR and GDH (glycerol dehydrogenase)
-
-
?
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
under physiological conditions, DhaT mostly catalyzes the forward reaction
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
-
-
-
?
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
-
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
under physiological conditions, DhaT mostly catalyzes the forward reaction
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
3-hydroxypropionaldehyde is an inhibitory intermediary metabolite in the 1,3-propanediol synthesis pathway during fermentation of raw material required for the synthesis of polytrimethylene terephthalate and other polyester fibers, accumulation of 3-hydroxypropanal in broth causes an irreversible cessation of the fermentation process
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
-
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
-
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
reduction of the aldehyde is the preferred reaction
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
reduction of the aldehyde is the preferred reaction, 3-hydroxypropanal is the preferred substrate
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
reduction of the aldehyde is the preferred reaction
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
reduction of the aldehyde is the preferred reaction, 3-hydroxypropanal is the preferred substrate
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
-
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
-
-
-
r
3-hydroxypropanal + NADH + H+
propane-1,3-diol + NAD+
-
-
-
-
r
3-hydroxypropanal + NADPH + H+

propane-1,3-diol + NADP+
-
improvement of propane-1,3-diol production by a novel propane-1,3-diol operon of three genes (dhaB1 and dhaB2 from Clostridium butyricum and YqhD from Escherichia coli) tandemly arrayed under the control of a constitutive, temperature-sensitive promoter in the vector pBV220 for heterologous expression in Escherichia coli
-
-
?
3-hydroxypropanal + NADPH + H+
propane-1,3-diol + NADP+
-
the Escherichia coli yqhD homolog can replace the function of DhaT in the Klebsiella pneumoniae AK mutant strain defective in 1,3-PD oxidoreductase activity (DhaT). The yqhD homolog restores propane-1,3-diol production and 1,3-PD oxidoreductase activity. Level of propane-1,3-diol production during batch fermentation in the recombinant strain is comparable to that of the parent strain
-
-
?
3-hydroxypropanal + NADPH + H+
propane-1,3-diol + NADP+
-
improvement of propane-1,3-diol production by a novel propane-1,3-diol operon of three genes (dhaB1 and dhaB2 from Clostridium butyricum and YqhD from Escherichia coli) tandemly arrayed under the control of a constitutive, temperature-sensitive promoter in the vector pBV220 for heterologous expression in Escherichia coli
-
-
?
3-hydroxypropanal + NADPH + H+
propane-1,3-diol + NADP+
NADPH is not substrate for wild-type, but for mutant D41G
-
-
r
3-hydroxypropionaldehyde + NADH

propane-1,3-diol + NAD+
-
recombinant mutant Clostridium acetobutylicum strain DG1(pSPD5) expressing the enzyme from an introduced plasmid
-
-
?
3-hydroxypropionaldehyde + NADH
propane-1,3-diol + NAD+
-
recombinant mutant Clostridium acetobutylicum strain DG1(pSPD5) expressing the enzyme from an introduced plasmid
-
-
?
3-hydroxypropionaldehyde + NADH
propane-1,3-diol + NAD+
-
-
-
-
?
3-hydroxypropionaldehyde + NADH
propane-1,3-diol + NAD+
-
-
-
-
?
3-hydroxypropionaldehyde + NADH + H+

propane-1,3-diol + NAD+
-
-
-
-
?
3-hydroxypropionaldehyde + NADH + H+
propane-1,3-diol + NAD+
-
-
-
-
?
3-hydroxypropionaldehyde + NADH + H+
propane-1,3-diol + NAD+
-
-
-
-
r
3-hydroxypropionaldehyde + NADH + H+
propane-1,3-diol + NAD+
-
the enzyme is important in vivo for convertion of glycerol into propane-1,3-diol as second step after dehydration of glycerol by coenzyme B12-dependent glycerol dehydratase
-
-
r
acetaldehyde + NADH + H+

ethanol + NAD+
-
-
-
?
acetaldehyde + NADH + H+
ethanol + NAD+
-
-
-
?
ethanol + NAD+

acetaldehyde + NADH + H+
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
-
-
-
r
ethanol + NAD+

NADH + ethanal
-
-
-
-
r
ethanol + NAD+
NADH + ethanal
-
-
-
-
?