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Information on EC 1.1.1.197 - 15-hydroxyprostaglandin dehydrogenase (NADP+)

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IUBMB Comments
Acts on prostaglandins E2, F2alpha and B1, but not on prostaglandin D2 [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+)]. May be identical with EC 1.1.1.189 prostaglandin-E2 9-reductase.
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The enzyme appears in viruses and cellular organisms
Synonyms
9-ketoprostaglandin reductase, carbonyl reductase, NADP-dependent 15-hydroxyprostaglandin dehydrogenase, NADP-linked 15-hydroxyprostglandin dehydrogenase, NADP-specific 15-hydroxyprostaglandin dehydrogenase, prostaglandin 9-ketoreductase, prostaglandin E 9-ketoreductase, type II 15-hydroxyprostaglandin dehydrogenase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP+ = (13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH + H+
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Acts on prostaglandins E2, F2alpha and B1, but not on prostaglandin D2[cf. EC1.1.1.141 (NADP)]. May be identical with EC1.1.1.189 prostaglandin-E2 9-reductase
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