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Information on EC 1.1.1.176 - 12alpha-hydroxysteroid dehydrogenase

for references in articles please use BRENDA:EC1.1.1.176
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IUBMB Comments
Catalyses the oxidation of the 12alpha-hydroxy group of bile acids, both in their free and conjugated form. Also acts on bile alcohols.
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
12alpha-hsdh, nad-dependent 12alpha-hydroxysteroid dehydrogenase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
cholate + NADP+ = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oate + NADPH + H+
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