Information on EC 1.1.1.164 - hexadecanol dehydrogenase

for references in articles please use BRENDA:EC1.1.1.164
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

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EC NUMBER
COMMENTARY hide
1.1.1.164
-
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RECOMMENDED NAME
GeneOntology No.
hexadecanol dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
hexadecanol + NAD+ = hexadecanal + NADH + H+
show the reaction diagram
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-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
hexadecanol:NAD+ oxidoreductase
The liver enzyme acts on long-chain alcohols from C8 to C16. The Euglena enzyme also oxidizes the corresponding aldehydes to fatty acids.
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CAS REGISTRY NUMBER
COMMENTARY hide
62213-59-6
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Z
-
-
Manually annotated by BRENDA team
Z
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
hexadecanal + NADH
hexadecanol + NAD+
show the reaction diagram
hexadecanol + NAD+
hexadecanal + NADH
show the reaction diagram
hexadecanol + NAD+
hexadecanal + NADH + H+
show the reaction diagram
additional information
?
-
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
hexadecanal + NADH
hexadecanol + NAD+
show the reaction diagram
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADP+
-
low activity
NADPH
-
utilized to a lesser extent than NADH
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
rifampicin
-
inhibits enzyme induction in hexadecanol-grown cells, not in cells grown on ethanol, palmitate or hexadecane
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0016 - 0.0073
hexadecanol
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0008
-
growth substrate of cells ethanol, assay substrate n-hexadecanol
0.0011
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growth substrate of cells palmitic acid, assay substrate n-hexadecanol
0.0046
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growth substrate of cells hexadecanol, assay substrate n-hexadecanol
0.0059
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growth substrate of cells hexadecane, assay substrate n-hexadecanol
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7
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aerobically grown mycelial cells
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
highly unstable, more than 50% loss of activity within 24 h
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20�C, Tris-HCl 10 mM, pH 7.8, precipitation at 50% ammonium sulfate saturation, dissolved in 15fold reduced volume
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 1.1.1.164)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)