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Information on EC 1.1.1.16 - galactitol 2-dehydrogenase and Organism(s) Rhizobium leguminosarum bv. viciae and UniProt Accession Q1MLL4

for references in articles please use BRENDA:EC1.1.1.16
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IUBMB Comments
Also converts other alditols containing an L-threo-configuration adjacent to a primary alcohol group into the corresponding sugars. The enzyme from Agrobacterium fabrum C58 is part of D-altritol and galactitol degradation pathways.
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Rhizobium leguminosarum bv. viciae
UNIPROT: Q1MLL4
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The taxonomic range for the selected organisms is: Rhizobium leguminosarum bv. viciae
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
galactitol dehydrogenase, dulcitol dehydrogenase, galactitol 2-dehydrogenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dulcitol dehydrogenase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
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oxidation
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reduction
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
galactitol:NAD+ 2-oxidoreductase
Also converts other alditols containing an L-threo-configuration adjacent to a primary alcohol group into the corresponding sugars. The enzyme from Agrobacterium fabrum C58 is part of D-altritol and galactitol degradation pathways.
CAS REGISTRY NUMBER
COMMENTARY hide
9028-23-3
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Saccharomyces cerevisiae
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
synthesis
a yeast strain capable of consuming lactose intracellularly is engineered to produce tagatose from lactose. GAL1 coding for galactose kinase is deleted to eliminate galactose utilization. Heterologous xylose reductase (XR) and galactitol dehydrogenase (GDH) are introduced into the Gal1 deletion strain. The expression levels of XR and GDH are adjusted to maximize tagatose production. The resulting engineered yeast produces 37.69 g/l of tagatose from lactose with a tagatose and galactose ratio of 9:1 in the reaction broth
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Liu, J.J.; Zhang, G.C.; Kwak, S.; Oh, E.J.; Yun, E.J.; Chomvong, K.; Cate, J.H.D.; Jin, Y.S.
Overcoming the thermodynamic equilibrium of an isomerization reaction through oxidoreductive reactions for biotransformation
Nat. Commun.
10
1356
2019
Rhizobium leguminosarum bv. viciae (Q1MLL4)
Manually annotated by BRENDA team