Information on EC 1.1.1.152 - 3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase

for references in articles please use BRENDA:EC1.1.1.152
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The expected taxonomic range for this enzyme is: Comamonas testosteroni

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EC NUMBER
COMMENTARY hide
1.1.1.152
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RECOMMENDED NAME
GeneOntology No.
3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3alpha-hydroxy-5beta-androstane-17-one + NAD+ = 5beta-androstane-3,17-dione + NADH + H+
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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-
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redox reaction
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-
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reduction
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Steroid hormone biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
3alpha-hydroxy-5beta-steroid:NAD+ 3-oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY hide
37250-77-4
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
2 strains, ATCC 11996 and STDH-m
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Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3alpha-hydroxy-5beta-androstane-17-one + NAD+
5beta-androstane-3,17-dione + NADH
show the reaction diagram
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etiocholanolone, strong substrate specificity
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ir
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
3alpha-hydroxy-5beta-androstane-17-one + NAD+
5beta-androstane-3,17-dione + NADH
show the reaction diagram
-
etiocholanolone, strong substrate specificity
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ir
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
47000
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meniscus depletion method, gel filtration
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
to homogeneity, chromatography techniques, preparative gel electrophoresis
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
analysis
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selective microquantitation of steroid substrates
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LINKS TO OTHER DATABASES (specific for EC-Number 1.1.1.152)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)