Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 1.1.1.145 - 3beta-hydroxy-DELTA5-steroid dehydrogenase and Organism(s) Sus scrofa and UniProt Accession Q9N119

for references in articles please use BRENDA:EC1.1.1.145
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
This activity is found in several bifunctional enzymes that catalyse the oxidative conversion of Delta5-3-hydroxy steroids to a Delta4-3-oxo configuration. This conversion is carried out in two separate, sequential reactions; in the first reaction, which requires NAD+, the enzyme catalyses the dehydrogenation of the 3beta-hydroxy steroid to a 3-oxo intermediate. In the second reaction the reduced coenzyme, which remains attached to the enzyme, activates the isomerization of the Delta5 form to a Delta4 form (cf. EC 5.3.3.1, steroid Delta-isomerase). Substrates include dehydroepiandrosterone (which is converted into androst-5-ene-3,17-dione), pregnenolone (converted to progesterone) and cholest-5-en-3-one, an intermediate of cholesterol degradation.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Sus scrofa
UNIPROT: Q9N119
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Sus scrofa
The enzyme appears in selected viruses and cellular organisms
Synonyms
hsd3b2, hsd3b, dhrs4, 3-beta-hydroxysteroid dehydrogenase, hsd3b6, 3betahsd2, 3beta hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase type ii, 3beta-hydroxysteroid dehydrogenase type 2, 3beta-hsd type ii, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3beta-HSD
-
3beta-hydroxysteroid dehydrogenase
-
3betaHSD
-
3-beta-hydroxy-5-ene steroid dehydrogenase
-
-
-
-
3-beta-hydroxy-delta(5)-steroid dehydrogenase
-
-
-
-
3-beta-hydroxysteroid dehydrogenase
-
-
3beta-HSD
-
-
3beta-HSDH
-
-
-
-
3beta-hydroxy steroid dehydrogenase/5-ene-4-ene isomerase
-
-
-
-
3beta-hydroxy steroid dehydrogenase/isomerase
-
-
-
-
3beta-hydroxy-5-ene steroid dehydrogenase
-
-
-
-
3beta-hydroxy-5-ene-steroid dehydrogenase
-
-
-
-
3beta-hydroxy-5-ene-steroid oxidoreductase
-
-
-
-
3beta-hydroxy-DELTA5-C27-steroid dehydrogenase/isomerase
-
-
-
-
3beta-hydroxy-DELTA5-C27-steroid oxidoreductase
-
-
-
-
3betaHSD
-
-
3betaHSD2
-
-
5-ene-3-beta-hydroxysteroid dehydrogenase
-
-
-
-
5alpha-dihydrotestosterone 3beta-hydroxysteroid dehydrogenase
-
-
-
-
dehydrogenase, 3beta-hydroxy-DELTA5-steroid
-
-
-
-
DELTA5-3beta-hydroxysteroid dehydrogenase
-
-
-
-
HSD3B1
-
-
HSDB1
-
-
progesterone reductase
-
-
-
-
steroid-DELTA5-3beta-ol dehydrogenase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
-
oxidation
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
3beta-hydroxy-DELTA5-steroid:NAD+ 3-oxidoreductase
This activity is found in several bifunctional enzymes that catalyse the oxidative conversion of Delta5-3-hydroxy steroids to a Delta4-3-oxo configuration. This conversion is carried out in two separate, sequential reactions; in the first reaction, which requires NAD+, the enzyme catalyses the dehydrogenation of the 3beta-hydroxy steroid to a 3-oxo intermediate. In the second reaction the reduced coenzyme, which remains attached to the enzyme, activates the isomerization of the Delta5 form to a Delta4 form (cf. EC 5.3.3.1, steroid Delta-isomerase). Substrates include dehydroepiandrosterone (which is converted into androst-5-ene-3,17-dione), pregnenolone (converted to progesterone) and cholest-5-en-3-one, an intermediate of cholesterol degradation.
CAS REGISTRY NUMBER
COMMENTARY hide
9044-85-3
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
androstenone + NADH
beta-androstenol + NAD+
show the reaction diagram
-
-
-
?
11beta,17alpha,21-trihydroxy-4-pregnen-3,20-dione + NADPH
3beta,11beta,17alpha,21-tetrahydroxy-4-pregnen-20-one + NADP+
show the reaction diagram
-
-
-
-
?
11beta,17alpha,21-trihydroxy-5alpha-pregnane-3,20-dione + NADPH
3beta,11beta,17alpha,21-tetrahydroxy-5alpha-pregnan-20-one + NADP+
show the reaction diagram
-
-
-
-
?
11beta,17alpha,21-trihydroxy-5beta-pregnane-3,20-dione + NADPH
3beta,11beta,17alpha,21-tetrahydroxy-5beta-pregnan-20-one + NADP+
show the reaction diagram
-
-
-
-
?
13,14-dihydro-15-keto-prostaglandin F2 + NADPH
?
show the reaction diagram
-
-
-
-
?
13,14-dihydro-15-keto-prostaglandin F2alpha + NADPH
?
show the reaction diagram
-
-
-
-
?
17-hydroxyprogesterone + NADPH
3beta,17-dihydroxy-4-pregnen-20-one + NADP+
show the reaction diagram
-
-
-
-
?
17beta-hydroxy-5alpha-androstane-3-one + NADPH
3beta,17beta-dihydroxy-5alpha-androstane + NADP+
show the reaction diagram
-
-
-
-
?
17beta-hydroxy-5beta-androstane-3-one + NADPH
3beta,17beta-dihydroxy-5beta-androstane + NADP+
show the reaction diagram
-
-
-
-
?
3beta,17alpha-dihydroxy-5-pregnen-20-one + NAD(P)+
17alpha-hydroxypregn-5-ene-3,20-dione + NAD(P)H
show the reaction diagram
-
-
-
-
?
3beta,7alpha-dihydroxy-5-cholestenoic acid + NAD+
7alpha-hydroxy-3-oxo-5-cholestenoic acid + NADH
show the reaction diagram
-
-
-
-
?
4-benzylpyridine + NADPH
?
show the reaction diagram
-
-
-
-
?
4-carboxybenzaldehyde + NADP+ + H2O
4-carboxybenzoic acid + NADPH + H+
show the reaction diagram
-
-
-
-
?
4-nitroacetophenone + NADPH
1-(4-nitrophenyl)ethanol + NADP+
show the reaction diagram
-
-
-
-
?
4-nitrobenzaldehyde + NADPH
4-nitrobenzyl alcohol + NADP+
show the reaction diagram
-
-
-
-
?
5,16-androstadien-3beta-ol + NAD+
5,16-androstadien-3-one + NADH
show the reaction diagram
-
-
-
-
?
5alpha-androstane-3,17-dione + NADPH
3beta-hydroxy-5alpha-androstane-17-one + NADP+
show the reaction diagram
-
-
-
-
?
5alpha-dihydrotestosterone + NADPH
5alpha-androstane-3beta,17beta-diol + NADP+
show the reaction diagram
-
-
-
-
?
5alpha-pregnane-3,20-dione + NAD(P)H
5alpha-pregnane-3beta-ol-20-one + NAD(P)+
show the reaction diagram
-
-
-
-
?
5beta-androstane-3,17-dione + NADPH
3beta-hydroxy-5beta-androstane-17-one + NADP+
show the reaction diagram
-
-
-
-
?
5beta-pregnane-3,20-dione + NAD(P)H + H+
5beta-pregnane-3beta-ol-20-one + NAD(P)+
show the reaction diagram
-
-
-
-
?
7alpha,25-dihydroxycholesterol + NAD+
7alpha,25-dihydroxy-4-cholesten-3-one + NADH
show the reaction diagram
-
-
-
-
?
7alpha,27-dihydroxycholesterol + NAD+
7alpha,27-dihydroxy-4-cholesten-3-one + NADH
show the reaction diagram
-
-
-
-
?
7alpha-hydroxycholesterol + NAD+
7alpha-hydroxy-4-cholesten-3-one + NADH
show the reaction diagram
-
-
-
-
?
9,10-phenanthrenequinone + NADPH
?
show the reaction diagram
-
-
-
-
?
9,10-phenanthrenequinone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
androstenedione + NADPH + H+
3beta-hydroxy-5-androsten-17-one + NADP+
show the reaction diagram
-
-
-
-
?
androstenone + NAD+
5alpha-androst-16-en-3beta-ol + NADH + H+
show the reaction diagram
-
-
-
-
?
camphorquinone + NADPH + H+
camphorquinol + NADP+
show the reaction diagram
-
-
-
-
?
caprinaldehyde + NADPH
?
show the reaction diagram
-
-
-
-
?
cyclohexanone + NADPH
cyclohexanol + NADP+
show the reaction diagram
-
-
-
-
?
D-galactose + NADPH
?
show the reaction diagram
-
-
-
-
?
D-glucose + NADPH
?
show the reaction diagram
-
-
-
-
?
D-glucuronic acid + NADPH
?
show the reaction diagram
-
-
-
-
?
D-glyceraldehyde + NADPH
?
show the reaction diagram
-
-
-
-
?
D-xylose + NADPH
?
show the reaction diagram
-
-
-
-
?
dehydroepiandrosterone + NAD+
androst-5-en-3,17-dione + NADH + H+
show the reaction diagram
-
-
-
-
?
dehydroepiandrosterone + NADPH
3beta-hydroxy-5-androsten-17-one + NADP+
show the reaction diagram
-
-
-
-
?
hydritantin + NADPH
?
show the reaction diagram
-
-
-
-
?
menadione + NADPH
menadiol + NADP+
show the reaction diagram
-
-
-
-
?
methylglyoxal + NADPH
?
show the reaction diagram
-
-
-
-
?
phenylglyoxal + NADPH
?
show the reaction diagram
-
-
-
-
?
pregnenolone + NAD(P)+
pregn-5-en-3,20-dione + NAD(P)H + H+
show the reaction diagram
-
-
-
-
?
pregnenolone + NAD+
pregn-5-en-3,20-dione + NADH + H+
show the reaction diagram
-
-
-
-
?
progesterone + NADPH
3beta-hydroxy-4-pregnen-20-one + NADP+
show the reaction diagram
-
-
-
-
?
prostaglandin E1 + NADPH
?
show the reaction diagram
-
-
-
-
?
prostaglandin E2 + NADPH
?
show the reaction diagram
-
-
-
-
?
testosterone + NADPH + H+
3beta,17beta-dihydroxy-4-androsten + NADP+
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
androstenone + NADH
beta-androstenol + NAD+
show the reaction diagram
-
-
-
?
androstenone + NAD+
5alpha-androst-16-en-3beta-ol + NADH + H+
show the reaction diagram
-
-
-
-
?
dehydroepiandrosterone + NAD+
androst-5-en-3,17-dione + NADH + H+
show the reaction diagram
-
-
-
-
?
pregnenolone + NAD(P)+
pregn-5-en-3,20-dione + NAD(P)H + H+
show the reaction diagram
-
-
-
-
?
pregnenolone + NAD+
pregn-5-en-3,20-dione + NADH + H+
show the reaction diagram
-
-
-
-
?
additional information
?
-
relationship between the expression of hepatic but not testicular enzyme with androstenone deposition in pig adipose tissue, overview
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADPH
-
testicular cytosol
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
trilostane
specific enzyme inhibitor
AgNO3
-
-
Cd2+
-
-
Co2+
-
-
Cu2+
-
-
deoxycorticosterone
-
-
Disulfiram
-
-
Hexestrol
-
-
Hg2+
-
-
Ni2+
-
-
p-chloromercuribenzoate
-
-
Stilbestrol
-
-
testosterone
-
-
trilostane
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0038
11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione
-
-
0.0827
11beta,17alpha,21-trihydroxy-5alpha-pregnane-3,20-dione
-
-
0.0461
11beta,17alpha,21-trihydroxy-5beta-pregnane-3,20-dione
-
-
0.0621
13,14-dihydro-15-keto-prostaglandin F2
-
-
0.13
13,14-dihydro-15-keto-prostaglandin F2alpha
-
-
0.206
17-hydroxyprogesterone
-
-
0.684
17beta-hydroxy-5alpha-androstane-3-one
-
-
0.231
17beta-hydroxy-5beta-androstane-3-one
-
-
2.097
4-benzylpyridine
-
-
0.319
4-carboxybenzaldehyde
-
-
0.137
4-Nitroacetophenone
-
-
1.966
4-nitrobenzaldehyde
-
-
1.043
5alpha-androstane-3,17-dione
-
-
0.217
5alpha-pregnane-3,20-dione
-
-
0.123
5beta-androstane-3,17-dione
-
-
0.246
5beta-pregnane-3,20-dione
-
-
0.003
7alpha,27-dihydroxycholesterol
-
-
0.0032
7alpha-hydroxycholesterol
-
-
2.408
9,10-phenanthrenequinone
-
-
0.0703
androstenedione
-
-
0.555
Camphorquinone
-
-
0.69
caprinaldehyde
-
-
1.663
cyclohexanone
-
-
0.287
D-galactose
-
-
0.122
D-glucose
-
-
0.465
D-glucuronic acid
-
-
1.07
D-glyceraldehyde
-
-
0.467
D-xylose
-
-
0.114
dehydroepiandrosterone
-
-
0.466
hydritantin
-
-
0.693
menadione
-
-
2.651
methylglyoxal
-
-
2.366
Phenylglyoxal
-
-
0.0346
progesterone
-
-
0.373
prostaglandin E1
-
-
0.0152
prostaglandin E2
-
-
0.0583
testosterone
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0033
-
7alpha,25-dihydroxycholesterol as substrate
0.0041
-
-
0.175
-
3beta,7alpha-dihydroxy-5-cholestenoic acid as substrate
0.838
-
7alpha,27-dihydroxycholesterol as substrate
1.489
-
7alpha-hydroxycholesterol as substrate
2.88
-
-
additional information
androstenone concentration in different tissues, overview
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.4
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
at early and mid pregnancy up to 71 days, 3beta-hydroxysteroid dehydrogenase protein is observed in large luteal cells, while on day 71, the enzyme is present exclusively in small luteal cells. Enzyme mRNA is detected in all investigated samples isolated at different stages of pregnancy
Manually annotated by BRENDA team
-
HSDB1 transcript abundance in the endometrium and myometrium remain at the same level during the examined days of pregnancy. After luteolysis both endometrial and myometrial HSD3B1 expression wane
Manually annotated by BRENDA team
-
HSDB1 transcript abundance in the endometrium and myometrium remain at the same level during the examined days of pregnancy. After luteolysis both endometrial and myometrial HSD3B1 expression wane
Manually annotated by BRENDA team
additional information
relationship between the expression of hepatic but not testicular enzyme with androstenone deposition in pig adipose tissue
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
isoform 3betaHSD2 associates with the inner mitochondrial membrane or outer mitochondrial membrane translocases facing the intermembrane space. Tthis interaction promotes the conformational change needed for full activity. 3betaHSD2 associates with the inner mitochondrial membrane but does not integrate into the membrane. 3betaHSD2 forms a transient association with the translocases Tim50 and Tom22 and with Tim23. This association occurs primarily through the interaction of Tim50 with the N-terminus of 3betaHSD2 and contributes to enzymatic activity. Tim50 knockdown inhibits catalysis of dehydroepiandrostenedione to androstenedione and pregnenolone to progesterone. Although Tim50 knockdown decreases 3betaHSD2 expression, restoration of expression via proteasome and protease inhibition does not rescue activity
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
physiological function
-
isoform 3betaHSD2 associates with the inner mitochondrial membrane but does not integrate into the membrane. 3betaHSD2 forms a transient association with the translocases Tim50 and Tom22 and with Tim23. This association occurs primarily through the interaction of Tim50 with the N-terminus of 3betaHSD2 and contributes to enzymatic activity. Tim50 knockdown inhibits catalysis of dehydroepiandrostenedione to androstenedione and pregnenolone to progesterone. Although Tim50 knockdown decreases 3betaHSD2 expression, restoration of expression via proteasome and protease inhibition does not rescue activity
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
3BHS_PIG
373
0
41882
Swiss-Prot
other Location (Reliability: 4)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
28000
-
gel filtration
31000
-
1 * 31000, SDS-PAGE
36000
-
x * 36000, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 36000, SDS-PAGE
monomer
-
1 * 31000, SDS-PAGE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA and amino acid sequence determination and analysis, tissue-specific expression analysis
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
independent of castration method, all castrated pigs show greater mRNA and protein expression of 3beta-HSD and lower levels of all steroids in plasma compared with entire males. There is a strong correlation between mRNA and protein expression of 3beta-HSD and steroid levels
after luteolysis both endometrial and myometrial HSD3B1 expression wane
-
HSDB1 transcript abundance in the endometrium and myometrium remain at the same level during the examined days of pregnancy
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nutrition
independent of castration method, all castrated pigs show greater mRNA and protein expression of 3beta-HSD and lower levels of all steroids in plasma compared with entire males. There is a strong correlation between mRNA and protein expression of 3beta-HSD and steroid levels
nutrition
-
expression of hepatic but not testicular 3beta-hydroxysteroid dehydrogenase shows a negative relationship with the level of backfat androsterone and is accompanied by a reduced rate of the hepatic androsterone clearance. Low expression of enzyme protein in the liver of high androsterone pigs is accompanied by a reduced level of enzyme mRNA
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Furster, C.; Zhang, J.; Toll, A.
Purification of a 3beta-hydroxy-D5-C27-steroid dehydrogenase from pig liver microsomes active in major and alternative pathways of bile acid biosynthesis
J. Biol. Chem.
271
20903-20907
1996
Sus scrofa
Manually annotated by BRENDA team
Hebert, P.; Cooke, G.M.
Kinetic evidence for separate 3beta-hydroxysteroid dehydrogenase-isomerases in androgen and 16-androstene biosynthetic pathways in the pig testis
J. Steroid Biochem. Mol. Biol.
42
901-910
1992
Sus scrofa
Manually annotated by BRENDA team
Nakajin, S.; Ishii, A.; Shinoda, M.
Purification and characterization of 5alpha-dihydrotestosterone 3beta-hydroxysteroid dehydrogenase from mature pig testicular cytosol
Biol. Pharm. Bull.
17
1155-1160
1994
Sus scrofa
Manually annotated by BRENDA team
Nicolau-Solano, S.I.; McGivan, J.D.; Whittington, F.M.; Nieuwhof, G.J.; Wood, J.D.; Doran, O.
Relationship between the expression of hepatic but not testicular 3beta-hydroxysteroid dehydrogenase with androstenone deposition in pig adipose tissue
J. Anim. Sci.
84
2809-2817
2006
Sus scrofa (Q9N119)
Manually annotated by BRENDA team
Nicolau-Solano, S.I.; Whittington, F.M.; Wood, J.D.; Doran, O.
Relationship between carcass weight, adipose tissue androstenone level and expression of the hepatic 3beta -hydroxysteroid dehydrogenase in entire commercial pigs
Animal
1
1053-1059
2007
Sus scrofa
Manually annotated by BRENDA team
Knapczyk, K.; Duda, M.; Czaplicki, D.; Slomczynska, M.
The presence of 3beta-hydroxysteroid dehydrogenase in the ovarian follicles and corpora lutea of pregnant swine
Exp. Clin. Endocrinol. Diabetes
115
411-416
2007
Sus scrofa
Manually annotated by BRENDA team
Pawlak, K.J.; Prasad, M.; Thomas, J.L.; Whittal, R.M.; Bose, H.S.
Inner mitochondrial translocase Tim50 interacts with 3beta-hydroxysteroid dehydrogenase type 2 to regulate adrenal and gonadal steroidogenesis
J. Biol. Chem.
286
39130-39140
2011
Sus scrofa
Manually annotated by BRENDA team
Wojciechowicz, B.; Kotwica, G.; Kolakowska, J.; Franczak, A.
The activity and localization of 3beta-hydroxysteroid dehydrogenase/DELTA(5)-DELTA(4) isomerase and release of androstenedione and progesterone by uterine tissues during early pregnancy and the estrous cycle in pigs
J. Reprod. Dev.
59
49-58
2013
Sus scrofa
Manually annotated by BRENDA team
Rasmussen, M.; Brunius, C.; Ekstrand, B.; Zamaratskaia, G.
Expression of hepatic 3beta-hydroxysteroid dehydrogenase and sulfotransferase 2A1 in entire and castrated male pigs
Mol. Biol. Rep.
39
7927-32
2012
Sus scrofa (Q9N119)
Manually annotated by BRENDA team
Smolinska, N.; Dobrzyn, K.; Kiezun, M.; Szeszko, K.; Maleszka, A.; Kaminski, T.
Effect of adiponectin on the steroidogenic acute regulatory protein, P450 side chain cleavage enzyme and 3beta-hydroxysteroid dehydrogenase gene expression, progesterone and androstenedione production by the porcine uterus during early pregnancy
J. Physiol. Pharmacol.
67
443-456
2016
Sus scrofa
Manually annotated by BRENDA team
Chen, G.; Bai, Y.; Ren, L.; Zhu, D.; Li, Y.; Fang, M.; Al-Kateb, H.; Doran, O.
Metabolism of androstenone, 17beta-estradiol and dihydrotestosterone in primary cultured pig hepatocytes and the role of 3beta-hydroxysteroid dehydrogenase in this process
PLoS ONE
10
e113194
2015
Sus scrofa
Manually annotated by BRENDA team