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Information on EC 1.1.1.14 - L-iditol 2-dehydrogenase and Organism(s) Saccharomyces cerevisiae and UniProt Accession Q07786

for references in articles please use BRENDA:EC1.1.1.14
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EC Tree
IUBMB Comments
This enzyme is widely distributed and has been described in archaea, bacteria, yeast, plants and animals. It acts on a number of sugar alcohols, including (but not limited to) L-iditol, D-glucitol, D-xylitol, and D-galactitol. Enzymes from different organisms or tissues display different substrate specificity. The enzyme is specific to NAD+ and can not use NADP+.
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Saccharomyces cerevisiae
UNIPROT: Q07786
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The taxonomic range for the selected organisms is: Saccharomyces cerevisiae
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
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L-iditol
+
NAD+
=
L-sorbose
+
NADH
+
H+
+
=
+
+
Synonyms
sorbitol dehydrogenase, polyol dehydrogenase, d-sorbitol dehydrogenase, nad-sdh, nad-dependent sorbitol dehydrogenase, glucitol dehydrogenase, mdsdh5, goscr, nad-sorbitol dehydrogenase, pdh-11300, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
sorbitol dehydrogenase 2
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dehydrogenase, L-iditol
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-
-
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glucitol dehydrogenase
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L-iditol 2-dehydrogenase
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L-iditol dehydrogenase (sorbitol)
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-
-
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L-iditol:NAD oxidoreductase
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-
-
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L-iditol:NAD+ 5-oxidoreductase
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-
-
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NAD+-dependent sorbitol dehydrogenase
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-
-
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NAD-dependent sorbitol dehydrogenase
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-
-
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NAD-sorbitol dehydrogenase
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-
-
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polyol dehydrogenase
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-
-
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Protein tms1
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sorbitol dehydrogenase
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sorbitol dehydrogenase 1
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
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oxidation
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reduction
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SYSTEMATIC NAME
IUBMB Comments
L-iditol:NAD+ 2-oxidoreductase
This enzyme is widely distributed and has been described in archaea, bacteria, yeast, plants and animals. It acts on a number of sugar alcohols, including (but not limited to) L-iditol, D-glucitol, D-xylitol, and D-galactitol. Enzymes from different organisms or tissues display different substrate specificity. The enzyme is specific to NAD+ and can not use NADP+.
CAS REGISTRY NUMBER
COMMENTARY hide
9028-21-1
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene SOR2
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
electrophoretic karyotyping and array-based comparative genomic hybridization (array-CGH), comparison of four different species derived from the Saccharomyces sensu stricto complex of 22 distillery strains, overview. The genomic diversity is mainly revealed within subtelomeric regions and the losses and/or gains of fragments of chromosomes I, III, VI and IX are the most frequently observed. Statistically significant differences in the gene copy number are documented in six functional gene categories: 1. telomere maintenance via recombination, DNA helicase activity or DNA binding, 2. maltose metabolism process, glucose transmembrane transporter activity, 3. asparagine catabolism, cellular response to nitrogen starvation, localized in cell wall-bounded periplasmic space, 4. siderophore transport, 5. response to copper ion, cadmium ion binding and 6. L-iditol 2-dehydrogenase activity. Distillery yeasts are diploid. Gene ontology overrepresentation profiles are species-specific
Manually annotated by BRENDA team
electrophoretic karyotyping and array-based comparative genomic hybridization (array-CGH), comparison of four different species derived from the Saccharomyces sensu stricto complex of 22 distillery strains, overview. The genomic diversity is mainly revealed within subtelomeric regions and the losses and/or gains of fragments of chromosomes I, III, VI and IX are the most frequently observed. Statistically significant differences in the gene copy number are documented in six functional gene categories: 1. telomere maintenance via recombination, DNA helicase activity or DNA binding, 2. maltose metabolism process, glucose transmembrane transporter activity, 3. asparagine catabolism, cellular response to nitrogen starvation, localized in cell wall-bounded periplasmic space, 4. siderophore transport, 5. response to copper ion, cadmium ion binding and 6. L-iditol 2-dehydrogenase activity. Distillery yeasts are diploid. Gene ontology overrepresentation profiles are species-specific
Manually annotated by BRENDA team
additional information
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
electrophoretic karyotyping and array-based comparative genomic hybridization (array-CGH), comparison of four different species derived from the Saccharomyces sensu stricto complex of 22 distillery strains, overview. The genomic diversity is mainly revealed within subtelomeric regions and the losses and/or gains of fragments of chromosomes I, III, VI and IX are the most frequently observed. Statistically significant differences in the gene copy number are documented in six functional gene categories: 1. telomere maintenance via recombination, DNA helicase activity or DNA binding, 2. maltose metabolism process, glucose transmembrane transporter activity, 3. asparagine catabolism, cellular response to nitrogen starvation, localized in cell wall-bounded periplasmic space, 4. siderophore transport, 5. response to copper ion, cadmium ion binding and 6. L-iditol 2-dehydrogenase activity. Distillery yeasts are diploid. Gene ontology overrepresentation profiles are species-specific
molecular karyotyping reveals the diversity of chromosome patterns, four strains with the most accented genetic variabilities are selected and subjected to genome-wide array-based comparativ genomic hybridization (array-CGH) analysis. The differences in the gene copy number are found in five functional gene categories: (1) maltose metabolism and transport, (2) response to toxin, (3) siderophore transport, (4) cellular aldehyde metabolic process, and (5) L-iditol 2-dehydrogenase activity. Genomic stability and nucleolus state are affected in Saflager W-34/70 strain
electrophoretic karyotyping and array-based comparative genomic hybridization (array-CGH), comparison of four different species derived from the Saccharomyces sensu stricto complex of 22 distillery strains, overview. The genomic diversity is mainly revealed within subtelomeric regions and the losses and/or gains of fragments of chromosomes I, III, VI and IX are the most frequently observed. Statistically significant differences in the gene copy number are documented in six functional gene categories: 1. telomere maintenance via recombination, DNA helicase activity or DNA binding, 2. maltose metabolism process, glucose transmembrane transporter activity, 3. asparagine catabolism, cellular response to nitrogen starvation, localized in cell wall-bounded periplasmic space, 4. siderophore transport, 5. response to copper ion, cadmium ion binding and 6. L-iditol 2-dehydrogenase activity. Distillery yeasts are diploid. Gene ontology overrepresentation profiles are species-specific
molecular karyotyping reveals the diversity of chromosome patterns, four strains with the most accented genetic variabilities are selected and subjected to genome-wide array-based comparativ genomic hybridization (array-CGH) analysis. The differences in the gene copy number are found in five functional gene categories: (1) maltose metabolism and transport, (2) response to toxin, (3) siderophore transport, (4) cellular aldehyde metabolic process, and (5) L-iditol 2-dehydrogenase activity. Genomic stability and nucleolus state are affected in Saflager W-34/70 strain
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Adamczyk, J.; Deregowska, A.; Skoneczny, M.; Skoneczna, A.; Natkanska, U.; Kwiatkowska, A.; Rawska, E.; Potocki, L.; Kuna, E.; Panek, A.; Lewinska, A.; Wnuk, M.
Copy number variations of genes involved in stress responses reflect the redox state and DNA damage in brewing yeasts
Cell Stress Chaperones
21
849-864
2016
Saccharomyces cerevisiae (P35497), Saccharomyces cerevisiae (Q07786), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Deregowska, A.; Skoneczny, M.; Adamczyk, J.; Kwiatkowska, A.; Rawska, E.; Skoneczna, A.; Lewinska, A.; Wnuk, M.
Genome-wide array-CGH analysis reveals YRF1 gene copy number variation that modulates genetic stability in distillery yeasts
Oncotarget
6
30650-30663
2015
Saccharomyces bayanus, Saccharomyces paradoxus, Saccharomyces kudriavzevii, Saccharomyces cerevisiae (P35497), Saccharomyces cerevisiae (Q07786)
Manually annotated by BRENDA team