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IUBMB CommentsThis enzyme is widely distributed and has been described in archaea, bacteria, yeast, plants and animals. It acts on a number of sugar alcohols, including (but not limited to) L-iditol, D-glucitol, D-xylitol, and D-galactitol. Enzymes from different organisms or tissues display different substrate specificity. The enzyme is specific to NAD+ and can not use NADP+.
Synonyms
sorbitol dehydrogenase, polyol dehydrogenase, d-sorbitol dehydrogenase, nad-sdh, nad-dependent sorbitol dehydrogenase, glucitol dehydrogenase, mdsdh5, nad-sorbitol dehydrogenase, goscr, pdh-11300,
more
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dehydrogenase, L-iditol
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glucitol dehydrogenase
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L-iditol 2-dehydrogenase
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L-iditol dehydrogenase (sorbitol)
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L-iditol:NAD oxidoreductase
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L-iditol:NAD+ 5-oxidoreductase
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NAD+-dependent sorbitol dehydrogenase
NAD-dependent polyol dehydrogenase
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NAD-dependent sorbitol dehydrogenase
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NAD-sorbitol dehydrogenase
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sorbitol dehydrogenase 1
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sorbitol dehydrogenase 2
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sorbitol related enzyme
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D-sorbitol dehydrogenase

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D-sorbitol dehydrogenase
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D-sorbitol dehydrogenase
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D-sorbitol dehydrogenase
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Dgeo_2865

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GoSCR

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NAD+-dependent sorbitol dehydrogenase

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NAD+-dependent sorbitol dehydrogenase
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PDH-11300

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polyol dehydrogenase

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polyol dehydrogenase
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SDH

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SldA

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SLDH

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sorbitol dehydrogenase

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sorbitol dehydrogenase
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sorbitol dehydrogenase
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sorbitol dehydrogenase
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sorbitol dehydrogenase
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sorbitol dehydrogenase
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sorbitol dehydrogenase
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sorbitol dehydrogenase
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sorbitol dehydrogenase
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SORD

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additional information

cf. EC 1.1.1.76
additional information
cf. EC 1.1.1.76
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additional information
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enzyme belongs to the family of medium-chain dehydrogenase/reductase proteins
additional information
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enzyme belongs to the family of medium-chain dehydrogenase/reductase proteins
additional information
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enzyme belongs to the family of medium-chain dehydrogenase/reductase proteins
additional information
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enzyme belongs to the family of medium-chain dehydrogenase/reductase proteins
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L-iditol + NAD+ = L-sorbose + NADH + H+
L-iditol + NAD+ = L-sorbose + NADH + H+

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L-iditol + NAD+ = L-sorbose + NADH + H+
ordered catalytic mechanism and substrate binding
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L-iditol + NAD+ = L-sorbose + NADH + H+
ordered catalytic mechanism and substrate binding
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L-iditol + NAD+ = L-sorbose + NADH + H+
ordered catalytic mechanism and substrate binding
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L-iditol + NAD+ = L-sorbose + NADH + H+
ordered catalytic mechanism and substrate binding, active site structure
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L-iditol:NAD+ 2-oxidoreductase
This enzyme is widely distributed and has been described in archaea, bacteria, yeast, plants and animals. It acts on a number of sugar alcohols, including (but not limited to) L-iditol, D-glucitol, D-xylitol, and D-galactitol. Enzymes from different organisms or tissues display different substrate specificity. The enzyme is specific to NAD+ and can not use NADP+.
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1,2-butanediol + NAD+
? + NADH + H+
1,2-hexanediol + NAD+
? + NADH + H+
2-hydroxyacetophenone + NADH + H+
(S)-1-phenyl-1,2-ethanediol + NAD+
3-deoxy-D-sorbitol + NAD+
? + NADH
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?
3-fluoro-D-sorbitol + NAD+
3-fluoro-D-fructose + NADH + H+
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r
4-deoxy-D-sorbitol + NAD+
4-deoxy-D-fructose + NADH + H+
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r
4-fluoro-D-sorbitol + NAD+
4-fluoro-D-fructose + NADH + H+
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r
6-deoxy-D-sorbitol + NAD+
? + NADH
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nearly 2fold higher activity compared to D-sorbitol
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?
6-fluoro-D-sorbitol + NAD+
? + NADH
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over 2fold higher activity compared to D-sorbitol, best substrate
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?
D-adonitol + NAD+
D-ribulose + NADH
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?
D-arabitol + NAD(P)+
D-xylulose + NAD(P)H + H+
D-arabitol + NAD+
D-xylulose + NADH + H+
D-fructose + NADH
?
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?
D-fructose + NADH + H+
D-sorbitol + NAD+
D-galactitol + NAD+
D-tagatose + NADH
D-galactitol + NAD+
D-tagatose + NADH + H+
D-glucitol + NAD+
D-fructose + NADH + H+
D-gluconate + NAD+
?
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low activity
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?
D-glucose + NADH
?
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low activity
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?
D-glycero-D-gluco-heptitol + NAD+
?
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?
D-mannitol + NAD(P)+
D-fructose + NAD(P)H + H+
D-mannitol + NAD+
D-fructose + NADH + H+
D-mannose + NADH
?
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low activity
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?
D-psicose + NADH
?
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?
D-raffinose + NADH
?
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low activity
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?
D-ribose + NADH
?
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low activity
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?
D-sorbitol + 2,6-dichlorophenolindophenol
L-sorbose + ?
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electron acceptor: i.e. DCIP
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?
D-sorbitol + acceptor
L-sorbose + reduced acceptor
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?
D-sorbitol + NAD(P)+
L-sorbose + NAD(P)H + H+
D-sorbitol + NAD+
? + NADH + H+
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?
D-sorbitol + NAD+
D-fructose + NADH + H+
D-sorbitol + NAD+
L-sorbose + NADH + H+
D-sorbose + NADH
?
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low activity
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?
D-tagatose + NADH
D-galactitol + NAD+
D-xylitol + NAD+
? + NADH + H+
D-xylitol + NADP+
? + NADPH + H+
NADP+ is not a cofactor for wild-type, but for a substrate-binding loop chimera
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?
ethanol + NAD+
acetaldehyde + NADH
glycerol + NAD+
?
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low activity
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?
glycerol + NAD+
dihydroxyacetone + NADH + H+
L-erythrulose + NADH
?
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?
L-rhamnose + NADH
?
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low activity
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?
meso-erythritol + NAD+
erythrulose + NADH
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high activity
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?
ribitol + NAD+
?
60% of the activity with D-sorbitol
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?
sorbitol + NAD+
D-fructose + NADH
Xylitol + NAD+
?
29% of the activity with D-sorbitol
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?
xylitol + NAD+
D-xylulose + NADH + H+
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r
additional information
?
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1,2-butanediol + NAD+

? + NADH + H+
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?
1,2-butanediol + NAD+
? + NADH + H+
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?
1,2-hexanediol + NAD+

? + NADH + H+
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?
1,2-hexanediol + NAD+
? + NADH + H+
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?
2-hydroxyacetophenone + NADH + H+

(S)-1-phenyl-1,2-ethanediol + NAD+
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?
2-hydroxyacetophenone + NADH + H+
(S)-1-phenyl-1,2-ethanediol + NAD+
99% enantiomeric excess
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?
2-hydroxyacetophenone + NADH + H+
(S)-1-phenyl-1,2-ethanediol + NAD+
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?
2-hydroxyacetophenone + NADH + H+
(S)-1-phenyl-1,2-ethanediol + NAD+
99% enantiomeric excess
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?
D-arabinose + NADH

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low activity
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?
D-arabinose + NADH
?
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low activity
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?
D-arabitol + NAD(P)+

D-xylulose + NAD(P)H + H+
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?
D-arabitol + NAD(P)+
D-xylulose + NAD(P)H + H+
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?
D-arabitol + NAD+

?
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D-arabinitol is identical, low activity
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?
D-arabitol + NAD+
?
Cereibacter sphaeroides Si4 / DSM 8371
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D-arabinitol is identical, low activity
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?
D-arabitol + NAD+
?
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D-arabinitol is identical, low activity
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?
D-arabitol + NAD+
?
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D-arabinitol is identical, low activity
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?
D-arabitol + NAD+
?
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D-arabinitol is identical, low activity
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?
D-arabitol + NAD+
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D-arabinitol is identical, low activity
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?
D-arabitol + NAD+

D-xylulose + NADH + H+
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best substrate
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?
D-arabitol + NAD+
D-xylulose + NADH + H+
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best substrate
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?
D-fructose + NADH + H+

D-sorbitol + NAD+
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?
D-fructose + NADH + H+
D-sorbitol + NAD+
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?
D-fructose + NADH + H+
D-sorbitol + NAD+
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?
D-fructose + NADH + H+
D-sorbitol + NAD+
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?
D-fructose + NADH + H+
D-sorbitol + NAD+
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?
D-fructose + NADH + H+
D-sorbitol + NAD+
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?
D-fructose + NADH + H+
D-sorbitol + NAD+
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?
D-fructose + NADH + H+
D-sorbitol + NAD+
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?
D-fructose + NADH + H+
D-sorbitol + NAD+
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?
D-fructose + NADH + H+
D-sorbitol + NAD+
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?
D-fructose + NADH + H+
D-sorbitol + NAD+
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?
D-fructose + NADH + H+
D-sorbitol + NAD+
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r
D-fructose + NADH + H+
D-sorbitol + NAD+
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?
D-galactitol + NAD+

D-tagatose + NADH
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?
D-galactitol + NAD+
D-tagatose + NADH
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r
D-galactitol + NAD+
D-tagatose + NADH
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low activity
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?
D-galactitol + NAD+
D-tagatose + NADH
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r
D-galactitol + NAD+
D-tagatose + NADH
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?
D-galactitol + NAD+

D-tagatose + NADH + H+
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?
D-galactitol + NAD+
D-tagatose + NADH + H+
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?
D-glucitol + NAD+

D-fructose + NADH + H+
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r
D-glucitol + NAD+
D-fructose + NADH + H+
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r
D-mannitol + NAD(P)+

D-fructose + NAD(P)H + H+
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?
D-mannitol + NAD(P)+
D-fructose + NAD(P)H + H+
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?
D-mannitol + NAD+

?
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low activity
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?
D-mannitol + NAD+
?
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low activity
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?
D-mannitol + NAD+
?
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low activity
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?
D-mannitol + NAD+
?
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low activity
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?
D-mannitol + NAD+
?
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?
D-mannitol + NAD+
?
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low activity
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?
D-mannitol + NAD+
?
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low activity
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?
D-mannitol + NAD+
?
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?
D-mannitol + NAD+
?
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?
D-mannitol + NAD+
?
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low activity
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?
D-mannitol + NAD+
?
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?
D-mannitol + NAD+
?
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low activity
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?
D-mannitol + NAD+
?
6% of the activity with D-sorbitol
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?
D-mannitol + NAD+
?
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?
D-mannitol + NAD+

D-fructose + NADH + H+
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?
D-mannitol + NAD+
D-fructose + NADH + H+
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?
D-ribitol + NAD+

?
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?
D-ribitol + NAD+
?
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?
D-ribitol + NAD+
?
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?
D-ribitol + NAD+
?
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?
D-ribitol + NAD+
?
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?
D-ribitol + NAD+
?
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?
D-ribitol + NAD+
?
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?
D-ribitol + NAD+
?
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?
D-ribitol + NAD+
?
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?
D-ribitol + NAD+
?
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?
D-ribulose + NADH

?
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?
D-ribulose + NADH
?
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?
D-ribulose + NADH
?
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?
D-ribulose + NADH
?
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?
D-ribulose + NADH
?
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?
D-sorbitol + NAD(P)+

L-sorbose + NAD(P)H + H+
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?
D-sorbitol + NAD(P)+
L-sorbose + NAD(P)H + H+
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?
D-sorbitol + NAD+

D-fructose + NADH + H+
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?
D-sorbitol + NAD+
D-fructose + NADH + H+
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?
D-sorbitol + NAD+
D-fructose + NADH + H+
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?
D-sorbitol + NAD+
D-fructose + NADH + H+
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?
D-sorbitol + NAD+
D-fructose + NADH + H+
-
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r
D-sorbitol + NAD+
D-fructose + NADH + H+
Cereibacter sphaeroides Si4 / DSM 8371
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r
D-sorbitol + NAD+
D-fructose + NADH + H+
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?
D-sorbitol + NAD+
D-fructose + NADH + H+
-
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r
D-sorbitol + NAD+
D-fructose + NADH + H+
-
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r
D-sorbitol + NAD+
D-fructose + NADH + H+
-
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r
D-sorbitol + NAD+
D-fructose + NADH + H+
-
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-
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?
D-sorbitol + NAD+
D-fructose + NADH + H+
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second step of the polyol pathway of glucose metabolism, important in diabetic disease and hyperglycaemia
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?
D-sorbitol + NAD+
D-fructose + NADH + H+
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i.e. D-glucitol, dissociation of the enzyme-coenzyme binary complex is the rate-limiting step, interaction of Zn2+ with Ser46 and the oxygen atom of the 2-hydroxy and the 4-hydroxy groups is important for substrate binding
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?
D-sorbitol + NAD+
D-fructose + NADH + H+
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r
D-sorbitol + NAD+
D-fructose + NADH + H+
-
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r
D-sorbitol + NAD+
D-fructose + NADH + H+
-
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?