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BRENDA support

Information on EC 1.1.1.105 - all-trans-retinol dehydrogenase (NAD+)

for references in articles please use BRENDA:EC1.1.1.105

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IUBMB Comments

The enzyme recognizes all-trans-retinol and all-trans-retinal as substrates and exhibits a strong preference for NAD+/NADH as cofactors. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form . No activity with 11-cis-retinol or 11-cis-retinal (c.f. EC 1.1.1.315, 11-cis retinol dehydrogenase). Also active with 3α-hydroxysteroids .

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
all-trans-retinol-[cellular-retinol-binding-protein]
+
=
all-trans-retinal-[cellular-retinol-binding-protein]
+
+

Synonyms
rdh, rdh12, rdh10, dhrs9, retinal reductase, rodh-4, retinol dehydrogenase 12, rdh16, retinol dehydrogenase 10, rdhe2, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
all-trans-retinol-[cellular-retinol-binding-protein] + NAD+ = all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
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