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Information on EC 1.1.1.10 - L-xylulose reductase and Organism(s) Caenorhabditis elegans and UniProt Accession Q21929

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EC Tree
     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.10 L-xylulose reductase
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This record set is specific for:
Caenorhabditis elegans
UNIPROT: Q21929 not found.
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Word Map
The taxonomic range for the selected organisms is: Caenorhabditis elegans
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
Synonyms
xylose reductase, l-xylulose reductase, dicarbonyl/l-xylulose reductase, nad(p)h-dependent xylose reductase, rplxr, rplxr3, nadp(+)-dependent xylitol dehydrogenase, nadp+-dependent xylitol dehydrogenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dicarbonyl/L-xylulose reductase
-
reductase, L-xylulose
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
-
oxidation
-
-
-
-
reduction
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -
SYSTEMATIC NAME
IUBMB Comments
xylitol:NADP+ 4-oxidoreductase (L-xylulose-forming)
-
CAS REGISTRY NUMBER
COMMENTARY hide
9028-17-5
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-erythrose + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
ir
D-threose + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
ir
D-xylulose + NADPH + H+
xylitol + NADP+
show the reaction diagram
-
-
-
?
L-erythrulose + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
ir
L-ribulose + NADPH + H+
? + NADP+
show the reaction diagram
low activity
-
-
?
L-xylulose + NADPH + H+
xylitol + NADP+
show the reaction diagram
-
-
-
ir
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-xylulose + NADPH + H+
xylitol + NADP+
show the reaction diagram
-
-
-
ir
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.27
D-erythrose
pH 7.0, temperature not specified in the publication
0.68
D-threose
pH 7.0, temperature not specified in the publication
2.58
D-xylulose
pH 7.0, temperature not specified in the publication
0.17
L-erythrulose
pH 7.0, temperature not specified in the publication
0.18
L-ribulose
pH 7.0, temperature not specified in the publication
0.66
L-xylulose
pH 7.0, temperature not specified in the publication
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.8
D-erythrose
pH 7.0, temperature not specified in the publication
2.32
D-threose
pH 7.0, temperature not specified in the publication
1.22
D-xylulose
pH 7.0, temperature not specified in the publication
3.32
L-erythrulose
pH 7.0, temperature not specified in the publication
0.49
L-ribulose
pH 7.0, temperature not specified in the publication
4.98
L-xylulose
pH 7.0, temperature not specified in the publication
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6.75
D-erythrose
pH 7.0, temperature not specified in the publication
3.42
D-threose
pH 7.0, temperature not specified in the publication
0.47
D-xylulose
pH 7.0, temperature not specified in the publication
19.03
L-erythrulose
pH 7.0, temperature not specified in the publication
0.36
L-ribulose
pH 7.0, temperature not specified in the publication
7.55
L-xylulose
pH 7.0, temperature not specified in the publication
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene dhs-21
UniProt
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
dhs-21 null mutants show defects in longevity, reproduction and egg-laying
metabolism
dicarbonyl/L-xylulose reductase converts L-xylulose into xylitol, and reduces various alpha-dicarbonyl compounds, performing a dual role in carbohydrate metabolism and detoxification
physiological function
the enzyme is essential for normal life span and reproduction
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DCXR_CAEEL
251
0
27219
Swiss-Prot
other Location (Reliability: 1)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene dhs-21, DNA and amino acid sequence determination and analysis, the dhs-21 gene is physically mapped to the cosmid R11D1 between the sma-1 and mes-4genes on chromosome V, expression of His6-tagged enzyme. Spatial and temporal expression pattern of the DHS-21-GFP construct in transgenic worms, overview
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
knock-down of daf-16 and elt-2 transcription factors affects dhs-21 expression
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Son, l.e..T.; Ko, K.M.; Cho, J.H.; Singaravelu, G.; Chatterjee, I.; Choi, T.W.; Song, H.O.; Yu, J.R.; Park, B.J.; Lee, S.K.; Ahnn, J.
DHS-21, a dicarbonyl/L-xylulose reductase (DCXR) ortholog, regulates longevity and reproduction in Caenorhabditis elegans
FEBS Lett.
585
1310-1316
2011
Caenorhabditis elegans (Q21929), Caenorhabditis elegans
Manually annotated by BRENDA team