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Information on EC 1.1.1.1 - alcohol dehydrogenase and Organism(s) Neurospora crassa and UniProt Accession Q9P6C8

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EC Tree
     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.1 alcohol dehydrogenase
IUBMB Comments
A zinc protein. Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.
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This record set is specific for:
Neurospora crassa
UNIPROT: Q9P6C8
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The taxonomic range for the selected organisms is: Neurospora crassa
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
adh, alcohol dehydrogenase, aldehyde dehydrogenase, adh1b, short-chain dehydrogenase/reductase, ssadh, adh1c, yeast alcohol dehydrogenase, retinol dehydrogenase, faldh, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
40 kDa allergen
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ADH
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-
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ADH-A2
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ADH-B2
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ADH-C2
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ADH-HT
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alcohol dehydrogenase (NAD)
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Alcohol dehydrogenase-B2
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aldehyde reductase
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aliphatic alcohol dehydrogenase
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dehydrogenase, alcohol
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ethanol dehydrogenase
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FALDH
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FDH
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Gastric alcohol dehydrogenase
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-
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Glutathione-dependent formaldehyde dehydrogenase
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GSH-FDH
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NAD-dependent alcohol dehydrogenase
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NAD-specific aromatic alcohol dehydrogenase
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NADH-alcohol dehydrogenase
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NADH-aldehyde dehydrogenase
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Octanol dehydrogenase
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primary alcohol dehydrogenase
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Retinol dehydrogenase
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yeast alcohol dehydrogenase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
oxidation
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reduction
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SYSTEMATIC NAME
IUBMB Comments
alcohol:NAD+ oxidoreductase
A zinc protein. Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.
CAS REGISTRY NUMBER
COMMENTARY hide
9031-72-5
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-butanol + NAD+
butanal + NADH + H+
show the reaction diagram
about 80% of activity with ethanol, ADH1
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-
?
1-hexanol + NAD+
hexanal + NADH + H+
show the reaction diagram
about 90% of activity with ethanol, ADH1
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-
?
1-octanol + NAD+
octanal + NADH + H+
show the reaction diagram
about 85% of activity with ethanol, ADH1
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-
?
1-pentanol + NAD+
pentanal + NADH + H+
show the reaction diagram
about 85% of activity with ethanol, ADH1
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-
?
1-propanol + NAD+
propanal + NADH + H+
show the reaction diagram
about 75% of activity with ethanol, ADH1
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?
2-butanol + NAD+
2-butanone + NADH + H+
show the reaction diagram
about 25% of activity with ethanol, ADH1
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-
?
2-propanol + NAD+
acetone + NADH + H+
show the reaction diagram
about 50% of activity with ethanol, ADH1
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?
ethanol + NAD+
acetaldehyde + NADH
show the reaction diagram
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-
?
(6S)-5,6-dihydro-6-methyl-4H-thieno[2,3b]thiopyran-4-one-7,7-dioxide + NADH + H+
(4S,6S)-5,6-dihydro-4-hydroxy-6-methyl-4H-thieno[2,3b]thiopyran-7,7-dioxide + NAD+
show the reaction diagram
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?
additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NAD+
ADH1 preferrs NAD+ 205fold better than NADP+ as cofactor
NAD+
ADH3 does not react with NADP+
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.3
calculated from sequence, ADH1
8.3
calculated from sequence
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
FGSC2489
SwissProt
Manually annotated by BRENDA team
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37443
x * 37443, ADH1, calculated from sequence
37983
x * 37983, ADH3, calculated from sequence
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 37443, ADH1, calculated from sequence
?
x * 37983, ADH3, calculated from sequence
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
ADH1 is expressed in recombinant Escherichia coli
ADH3 is expressed in recombinant Escherichia coli
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
synthesis
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production of (4S,6S)-5,6-dihydro-4-hydroxy-6-methyl-4H-thieno[2,3b]thiopyran-7,7dioxide, which is an intermediate in the synthesis of the carbonic anhydrase inhibitor trusopt. Trusopt is a novel, topically active treatment for glaucoma
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Blacklock, T.J.; Sohar, P.; Butcher, J.W.; Lamanec, T.; Grabowski, E.J.J.
An enantioselective synthesis of the topically-active carbonic anhydrase inhibitor MK-0507:5,6-dihydro-(s)-4-(ethylamino)-(s)-6-mehtyl-4H-thieno[2,3-beta]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride
J. Org. Chem.
58
1672-1679
1993
Neurospora crassa
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Manually annotated by BRENDA team
Park, Y.C.; San, K.Y.; Bennett, G.N.
Characterization of alcohol dehydrogenase 1 and 3 from Neurospora crassa FGSC2489
Appl. Microbiol. Biotechnol.
76
349-356
2007
Neurospora crassa, Neurospora crassa (Q9P6C8), Neurospora crassa DSM 1257 (Q9P6C8), Neurospora crassa FGSC2489
Manually annotated by BRENDA team