EC Explorer

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precorrin-2 dehydrogenase
precorrin-2 + NAD+ = sirohydrochlorin + NADH + H+
uroporphyrinogen-III C-methyltransferase
2 S-adenosyl-L-methionine + uroporphyrinogen III = 2 S-adenosyl-L-homocysteine + precorrin-2 (overall reaction);; (1a) S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1;;(1b) S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2
sirohydrochlorin ferrochelatase
siroheme + 2 H+ = sirohydrochlorin + Fe2+
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