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EC 6.3.2.17 Details
EC number
6.3.2.17
Accepted name
tetrahydrofolate synthase
Reaction
ATP + tetrahydropteroyl-[γ-Glu]n + L-glutamate = ADP + phosphate + tetrahydropteroyl-[γ-Glu]n+1
Other name(s)
folylpolyglutamate synthase, folate polyglutamate synthetase, formyltetrahydropteroyldiglutamate synthetase, N10-formyltetrahydropteroyldiglutamate synthetase, folylpoly-γ-glutamate synthase, folylpolyglutamyl synthetase, folylpoly(γ-glutamate) synthase, folylpolyglutamate synthetase, FPGS, tetrahydrofolylpolyglutamate synthase, tetrahydrofolate:L-glutamate γ-ligase (ADP-forming), tetrahydropteroyl-[γ-Glu]n:L-glutamate γ-ligase (ADP-forming)
Systematic name
tetrahydropteroyl-γ-polyglutamate:L-glutamate γ-ligase (ADP-forming)
CAS registry number
63363-84-8
Comment
In some bacteria, a single protein catalyses both this activity and that of EC 6.3.2.12, dihydrofolate synthase [3], the combined activity of which leads to the formation of the coenzyme polyglutamated tetrahydropteroate (H4PteGlun), i.e. various tetrahydrofolates (H4folate). In contrast, the activities are located on separate proteins in most eukaryotes studied to date [4]. In Arabidopsis thaliana, this enzyme is present as distinct isoforms in the mitochondria, the cytosol and the chloroplast. Each isoform is encoded by a separate gene, a situation that is unique among eukaryotes [4]. As the affinity of folate-dependent enzymes increases markedly with the number of glutamic residues, the tetrahydropteroyl polyglutamates are the preferred coenzymes of C1 metabolism. (reviewed in [5]). The enzymes from different sources (particularly eukaryotes versus prokaryotes) have different substrate specificities with regard to one-carbon substituents and the number of glutamate residues present on the tetrahydrofolates.
History
created 1984, modified 2003, modified 2005
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EC Tree
1 Oxidoreductases
2 Transferases
3 Hydrolases
4 Lyases
5 Isomerases
6 Ligases
6.1 Forming carbon-oxygen bonds
6.2 Forming carbon-sulfur bonds
6.3 Forming carbon-nitrogen bonds
6.3.1 Acid—ammonia (or amine) ligases (amide synthases)
6.3.2 Acid—amino-acid ligases (peptide synthases)
6.3.2.1 pantoate—β-alanine ligase (AMP-forming)
6.3.2.2 glutamate—cysteine ligase
6.3.2.3 glutathione synthase
6.3.2.4 D-alanine—D-alanine ligase
6.3.2.5 phosphopantothenate—cysteine ligase (CTP)
6.3.2.6 phosphoribosylaminoimidazolesuccinocarboxamide synthase
6.3.2.7 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—L-lysine ligase
6.3.2.8 UDP-N-acetylmuramate—L-alanine ligase
6.3.2.9 UDP-N-acetylmuramoyl-L-alanine—D-glutamate ligase
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide—D-alanyl-D-alanine ligase
6.3.2.11 carnosine synthase
6.3.2.12 dihydrofolate synthase
6.3.2.13 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—2,6-diaminopimelate ligase
6.3.2.14 enterobactin synthase
6.3.2.15 created 1976, deleted 2002
6.3.2.16 D-alanine—alanyl-poly(glycerolphosphate) ligase
6.3.2.17 tetrahydrofolate synthase
6.3.2.18 γ-glutamylhistamine synthase
6.3.2.19 ubiquitin—protein ligase
6.3.2.20 indoleacetate—lysine synthetase
6.3.2.21 ubiquitin—calmodulin ligase
6.3.2.22 diphthine—ammonia ligase
6.3.2.23 homoglutathione synthase
6.3.2.24 tyrosine—arginine ligase
6.3.2.25 tubulin—tyrosine ligase
6.3.2.26 N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
6.3.2.27 aerobactin synthase
6.3.2.28 L-amino-acid α-ligase
6.3.2.29 cyanophycin synthase (L-aspartate-adding)
6.3.2.30 cyanophycin synthase (L-arginine-adding)
6.3.2.31 coenzyme F420-0:L-glutamate ligase
6.3.2.32 coenzyme γ-F420-2:α-L-glutamate ligase
6.3.2.33 tetrahydrosarcinapterin synthase
6.3.2.34 coenzyme F420-1:γ-L-glutamate ligase
6.3.2.35 D-alanine—D-serine ligase
6.3.2.36 4-phosphopantoate—β-alanine ligase
6.3.2.37 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—D-lysine ligase
6.3.2.38 N2-citryl-N6-acetyl-N6-hydroxylysine synthase
6.3.2.39 aerobactin synthase
6.3.2.40 cyclopeptine synthase
6.3.2.41 N-acetylaspartylglutamate synthase
6.3.2.42 N-acetylaspartylglutamylglutamate synthase
6.3.2.43 [amino-group carrier protein]—L-2-aminoadipate ligase
6.3.2.44 pantoate—β-alanine ligase (ADP-forming)
6.3.2.45 UDP-N-acetylmuramate—L-alanyl-γ-D-glutamyl-meso-2,6-diaminoheptanedioate ligase
6.3.2.46 fumarate—(S)-2,3-diaminopropanoate ligase
6.3.2.47 dapdiamide synthase
6.3.2.48 L-arginine-specific L-amino acid ligase
6.3.2.49 L-alanine—L-anticapsin ligase
6.3.2.50 tenuazonic acid synthetase
6.3.2.51 phosphopantothenate—cysteine ligase (ATP)
6.3.2.52 jasmonoyl—L-amino acid ligase
6.3.2.53 UDP-N-acetylmuramoyl-L-alanine—L-glutamate ligase
6.3.2.54 L-2,3-diaminopropanoate—citrate ligase
6.3.2.55 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase
6.3.2.56 staphyloferrin B synthase
6.3.2.57 staphyloferrin A synthase
6.3.2.58 D-ornithine—citrate ligase
6.3.2.59 3-methyl-D-ornithine—L-lysine ligase
6.3.2.60 glutamate—[amino group carrier protein] ligase
6.3.2.61 tubulin-glutamate ligase
6.3.2.62 β-tubulin-glutamate ligase
6.3.3 Cyclo-ligases
6.3.4 Other carbon-nitrogen ligases
6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor
6.4 Forming carbon-carbon bonds
6.5 Forming phosphoric-ester bonds
6.6 Forming nitrogen—metal bonds
6.7 Forming nitrogen-nitrogen bonds
7 Translocases