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EC 6.3.2.12 Details
EC number
6.3.2.12
Accepted name
dihydrofolate synthase
Reaction
ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8-dihydropteroylglutamate
Other name(s)
dihydrofolate synthetase, 7,8-dihydrofolate synthetase, H2-folate synthetase, 7,8-dihydropteroate:L-glutamate ligase (ADP), dihydropteroate:L-glutamate ligase (ADP-forming), DHFS
Systematic name
7,8-dihydropteroate:L-glutamate ligase (ADP-forming)
CAS registry number
37318-62-0
Comment
In some bacteria, a single protein catalyses both this activity and that of EC 6.3.2.17, tetrahydrofolate synthase [2], the combined activity of which leads to the formation of the coenzyme polyglutamated tetrahydropteroate (H4PteGlun), i.e. various tetrahydrofolates. In contrast, the activities are located on separate proteins in most eukaryotes studied to date [3]. This enzyme is reponsible for attaching the first glutamate residue to dihydropteroate to form dihydrofolate and is present only in those organisms that have the ability to synthesize tetrahydrofolate de novo, e.g. plants, most bacteria, fungi and protozoa [3].
History
created 1972, modified 2005
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EC Tree
1 Oxidoreductases
2 Transferases
3 Hydrolases
4 Lyases
5 Isomerases
6 Ligases
6.1 Forming carbon-oxygen bonds
6.2 Forming carbon-sulfur bonds
6.3 Forming carbon-nitrogen bonds
6.3.1 Acid—ammonia (or amine) ligases (amide synthases)
6.3.2 Acid—amino-acid ligases (peptide synthases)
6.3.2.1 pantoate—β-alanine ligase (AMP-forming)
6.3.2.2 glutamate—cysteine ligase
6.3.2.3 glutathione synthase
6.3.2.4 D-alanine—D-alanine ligase
6.3.2.5 phosphopantothenate—cysteine ligase (CTP)
6.3.2.6 phosphoribosylaminoimidazolesuccinocarboxamide synthase
6.3.2.7 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—L-lysine ligase
6.3.2.8 UDP-N-acetylmuramate—L-alanine ligase
6.3.2.9 UDP-N-acetylmuramoyl-L-alanine—D-glutamate ligase
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide—D-alanyl-D-alanine ligase
6.3.2.11 carnosine synthase
6.3.2.12 dihydrofolate synthase
6.3.2.13 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—2,6-diaminopimelate ligase
6.3.2.14 enterobactin synthase
6.3.2.15 created 1976, deleted 2002
6.3.2.16 D-alanine—alanyl-poly(glycerolphosphate) ligase
6.3.2.17 tetrahydrofolate synthase
6.3.2.18 γ-glutamylhistamine synthase
6.3.2.19 ubiquitin—protein ligase
6.3.2.20 indoleacetate—lysine synthetase
6.3.2.21 ubiquitin—calmodulin ligase
6.3.2.22 diphthine—ammonia ligase
6.3.2.23 homoglutathione synthase
6.3.2.24 tyrosine—arginine ligase
6.3.2.25 tubulin—tyrosine ligase
6.3.2.26 N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
6.3.2.27 aerobactin synthase
6.3.2.28 L-amino-acid α-ligase
6.3.2.29 cyanophycin synthase (L-aspartate-adding)
6.3.2.30 cyanophycin synthase (L-arginine-adding)
6.3.2.31 coenzyme F420-0:L-glutamate ligase
6.3.2.32 coenzyme γ-F420-2:α-L-glutamate ligase
6.3.2.33 tetrahydrosarcinapterin synthase
6.3.2.34 coenzyme F420-1:γ-L-glutamate ligase
6.3.2.35 D-alanine—D-serine ligase
6.3.2.36 4-phosphopantoate—β-alanine ligase
6.3.2.37 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—D-lysine ligase
6.3.2.38 N2-citryl-N6-acetyl-N6-hydroxylysine synthase
6.3.2.39 aerobactin synthase
6.3.2.40 cyclopeptine synthase
6.3.2.41 N-acetylaspartylglutamate synthase
6.3.2.42 N-acetylaspartylglutamylglutamate synthase
6.3.2.43 [amino-group carrier protein]—L-2-aminoadipate ligase
6.3.2.44 pantoate—β-alanine ligase (ADP-forming)
6.3.2.45 UDP-N-acetylmuramate—L-alanyl-γ-D-glutamyl-meso-2,6-diaminoheptanedioate ligase
6.3.2.46 fumarate—(S)-2,3-diaminopropanoate ligase
6.3.2.47 dapdiamide synthase
6.3.2.48 L-arginine-specific L-amino acid ligase
6.3.2.49 L-alanine—L-anticapsin ligase
6.3.2.50 tenuazonic acid synthetase
6.3.2.51 phosphopantothenate—cysteine ligase (ATP)
6.3.2.52 jasmonoyl—L-amino acid ligase
6.3.2.53 UDP-N-acetylmuramoyl-L-alanine—L-glutamate ligase
6.3.2.54 L-2,3-diaminopropanoate—citrate ligase
6.3.2.55 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase
6.3.2.56 staphyloferrin B synthase
6.3.2.57 staphyloferrin A synthase
6.3.2.58 D-ornithine—citrate ligase
6.3.2.59 3-methyl-D-ornithine—L-lysine ligase
6.3.2.60 glutamate—[amino group carrier protein] ligase
6.3.2.61 tubulin-glutamate ligase
6.3.2.62 β-tubulin-glutamate ligase
6.3.3 Cyclo-ligases
6.3.4 Other carbon-nitrogen ligases
6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor
6.4 Forming carbon-carbon bonds
6.5 Forming phosphoric-ester bonds
6.6 Forming nitrogen—metal bonds
6.7 Forming nitrogen-nitrogen bonds
7 Translocases