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EC 3.5.4.9 Details

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EC number

3.5.4.9

Accepted name

methenyltetrahydrofolate cyclohydrolase

Reaction

5,10-methenyltetrahydrofolate + H₂O = 10-formyltetrahydrofolate

Other name(s)

Citrovorum factor cyclodehydrase, cyclohydrolase, formyl-methenyl-methylenetetrahydrofolate synthetase (combined), 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)

Systematic name

5,10-methenyltetrahydrofolate 5-hydrolase (ring-opening)

CAS registry number

9027-97-8

Comment

In eukaryotes, the enzyme occurs as a trifunctional enzyme that also has methylenetetrahydrofolate dehydrogenase (NADP⁺) (EC 1.5.1.5) and formate—tetrahydrofolate ligase (EC 6.3.4.3) activity. In some prokaryotes, it occurs as a bifunctional enzyme that also has dehydrogenase (EC 1.5.1.5) activity or formimidoyltetrahydrofolate cyclodeaminase (EC 4.3.1.4) activity.

History

created 1961

EC Tree

1 Oxidoreductases

2 Transferases

3 Hydrolases

3.1 Acting on ester bonds

3.2 Glycosylases

3.3 Acting on ether bonds

3.4 Acting on peptide bonds (peptidases)

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.1 In linear amides

3.5.2 In cyclic amides

3.5.3 In linear amidines

3.5.4 In cyclic amidines

3.5.4.1 cytosine deaminase

3.5.4.2 adenine deaminase

3.5.4.3 guanine deaminase

3.5.4.4 adenosine deaminase

3.5.4.5 cytidine deaminase

3.5.4.6 AMP deaminase

3.5.4.7 ADP deaminase

3.5.4.8 aminoimidazolase

3.5.4.9 methenyltetrahydrofolate cyclohydrolase

3.5.4.10 IMP cyclohydrolase

3.5.4.11 pterin deaminase

3.5.4.12 dCMP deaminase

3.5.4.13 dCTP deaminase

3.5.4.14 deoxycytidine deaminase

3.5.4.15 guanosine deaminase

3.5.4.16 GTP cyclohydrolase I

3.5.4.17 adenosine-phosphate deaminase

3.5.4.18 ATP deaminase

3.5.4.19 phosphoribosyl-AMP cyclohydrolase

3.5.4.20 pyrithiamine deaminase

3.5.4.21 creatinine deaminase

3.5.4.22 1-pyrroline-4-hydroxy-2-carboxylate deaminase

3.5.4.23 blasticidin-S deaminase

3.5.4.24 sepiapterin deaminase

3.5.4.25 GTP cyclohydrolase II

3.5.4.26 diaminohydroxyphosphoribosylaminopyrimidine deaminase

3.5.4.27 methenyltetrahydromethanopterin cyclohydrolase

3.5.4.28 S-adenosylhomocysteine deaminase

3.5.4.29 GTP cyclohydrolase IIa

3.5.4.30 dCTP deaminase (dUMP-forming)

3.5.4.31 S-methyl-5′-thioadenosine deaminase

3.5.4.32 8-oxoguanine deaminase

3.5.4.33 tRNA(adenine³⁴) deaminase

3.5.4.34 tRNA^Ala(adenine³⁷) deaminase

3.5.4.35 tRNA(cytosine⁸) deaminase

3.5.4.36 mRNA(cytosine⁶⁶⁶⁶) deaminase

3.5.4.37 double-stranded RNA adenine deaminase

3.5.4.38 single-stranded DNA cytosine deaminase

3.5.4.39 GTP cyclohydrolase IV

3.5.4.40 aminodeoxyfutalosine deaminase

3.5.4.41 5′-deoxyadenosine deaminase

3.5.4.42 N-isopropylammelide isopropylaminohydrolase

3.5.4.43 hydroxydechloroatrazine ethylaminohydrolase

3.5.4.44 ectoine hydrolase

3.5.4.45 melamine deaminase

3.5.4.46 cAMP deaminase

3.5.5 In nitriles

3.5.99 In other compounds

3.6 Acting on acid anhydrides

3.7 Acting on carbon-carbon bonds

3.8 Acting on halide bonds

3.9 Acting on phosphorus-nitrogen bonds

3.10 Acting on sulfur-nitrogen bonds

3.11 Acting on carbon-phosphorus bonds

3.12 Acting on sulfur-sulfur bonds

3.13 Acting on carbon-sulfur bonds