Any feedback?
Please rate this page
(ecexplorer.php)
(0/150)

BRENDA support

EC Explorer

[browse EC tree] - [search]
EC 3.2.1.114 Details
EC number
3.2.1.114
Accepted name
mannosyl-oligosaccharide 1,3-1,6-α-mannosidase
Reaction
Man5GlcNAc3-[protein] + 2 H2O = Man3GlcNAc3-[protein] + 2 α-D-mannopyranose
Other name(s)
MAN2A1 (gene name), MAN2A2 (gene name), mannosidase II, exo-1,3-1,6-α-mannosidase, α-D-mannosidase II, α-mannosidase II, α1-3,6-mannosidase, GlcNAc transferase I-dependent α1,3[α1,6]mannosidase, Golgi α-mannosidase II, ManII, 1,3(1,6)-α-D-mannosidase, 1,3-(1,6-)mannosyl-oligosaccharide α-D-mannohydrolase, (1→3)-(1→6)-mannosyl-oligosaccharide α-D-mannohydrolase
Systematic name
(1→3)-(1→6)-mannosyl-oligosaccharide α-D-mannohydrolase (configuration-retaining)
CAS registry number
82047-77-6
Comment
The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus. It removes two mannosyl residues, one linked by α1,3 linkage, and the other linked by α1,6 linkage, both of which are removed by the same catalytic site. The enzyme is sensitive to swainsonine.
History
created 1986, modified 2018
back to top
EC Tree
1 Oxidoreductases
2 Transferases
3 Hydrolases
3.1 Acting on ester bonds
3.2 Glycosylases
3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
3.2.1.1 α-amylase
3.2.1.2 β-amylase
3.2.1.3 glucan 1,4-α-glucosidase
3.2.1.4 cellulase
3.2.1.5 created 1961, deleted 1964
3.2.1.6 endo-1,3(4)-β-glucanase
3.2.1.7 inulinase
3.2.1.8 endo-1,4-β-xylanase
3.2.1.9 created 1961, deleted 1972
3.2.1.10 oligo-1,6-glucosidase
3.2.1.11 dextranase
3.2.1.12 created 1961, deleted 1976
3.2.1.13 created 1961, deleted 1976
3.2.1.14 chitinase
3.2.1.15 endo-polygalacturonase
3.2.1.16 created 1961, deleted 1972
3.2.1.17 lysozyme
3.2.1.18 exo-α-sialidase
3.2.1.19 created 1961, deleted 1978
3.2.1.20 α-glucosidase
3.2.1.21 β-glucosidase
3.2.1.22 α-galactosidase
3.2.1.23 β-galactosidase
3.2.1.24 α-mannosidase
3.2.1.25 β-mannosidase
3.2.1.26 β-fructofuranosidase
3.2.1.27 created 1961, deleted 1972
3.2.1.28 α,α-trehalase
3.2.1.29 created 1961, deleted 1972
3.2.1.30 created 1961, deleted 1992
3.2.1.31 β-glucuronidase
3.2.1.32 endo-1,3-β-xylanase
3.2.1.33 amylo-α-1,6-glucosidase
3.2.1.34 created 1965, deleted 1972
3.2.1.35 hyaluronoglucosaminidase
3.2.1.36 hyaluronoglucuronidase
3.2.1.37 xylan 1,4-β-xylosidase
3.2.1.38 β-D-fucosidase
3.2.1.39 glucan endo-1,3-β-D-glucosidase
3.2.1.40 α-L-rhamnosidase
3.2.1.41 pullulanase
3.2.1.42 GDP-glucosidase
3.2.1.43 β-L-rhamnosidase
3.2.1.44 fucoidanase
3.2.1.45 glucosylceramidase
3.2.1.46 galactosylceramidase
3.2.1.47 galactosylgalactosylglucosylceramidase
3.2.1.48 sucrose α-glucosidase
3.2.1.49 α-N-acetylgalactosaminidase
3.2.1.50 α-N-acetylglucosaminidase
3.2.1.51 α-L-fucosidase
3.2.1.52 β-N-acetylhexosaminidase
3.2.1.53 β-N-acetylgalactosaminidase
3.2.1.54 cyclomaltodextrinase
3.2.1.55 non-reducing end α-L-arabinofuranosidase
3.2.1.56 glucuronosyl-disulfoglucosamine glucuronidase
3.2.1.57 isopullulanase
3.2.1.58 glucan 1,3-β-glucosidase
3.2.1.59 glucan endo-1,3-α-glucosidase
3.2.1.60 glucan 1,4-α-maltotetraohydrolase
3.2.1.61 mycodextranase
3.2.1.62 glycosylceramidase
3.2.1.63 1,2-α-L-fucosidase
3.2.1.64 2,6-β-fructan 6-levanbiohydrolase
3.2.1.65 levanase
3.2.1.66 quercitrinase
3.2.1.67 galacturonan 1,4-α-galacturonidase
3.2.1.68 isoamylase
3.2.1.69 created 1972, deleted 1976
3.2.1.70 glucan 1,6-α-glucosidase
3.2.1.71 glucan endo-1,2-β-glucosidase
3.2.1.72 xylan 1,3-β-xylosidase
3.2.1.73 licheninase
3.2.1.74 glucan 1,4-β-glucosidase
3.2.1.75 glucan endo-1,6-β-glucosidase
3.2.1.76 L-iduronidase
3.2.1.77 mannan 1,2-(1,3)-α-mannosidase
3.2.1.78 mannan endo-1,4-β-mannosidase
3.2.1.79 created 1972, deleted 1976
3.2.1.80 fructan β-fructosidase
3.2.1.81 β-agarase
3.2.1.82 exo-poly-α-digalacturonosidase
3.2.1.83 κ-carrageenase
3.2.1.84 glucan 1,3-α-glucosidase
3.2.1.85 6-phospho-β-galactosidase
3.2.1.86 6-phospho-β-glucosidase
3.2.1.87 capsular-polysaccharide endo-1,3-α-galactosidase
3.2.1.88 non-reducing end β-L-arabinopyranosidase
3.2.1.89 arabinogalactan endo-β-1,4-galactanase
3.2.1.90 created 1976, deleted 2001
3.2.1.91 cellulose 1,4-β-cellobiosidase (non-reducing end)
3.2.1.92 peptidoglycan β-N-acetylmuramidase
3.2.1.93 α,α-phosphotrehalase
3.2.1.94 glucan 1,6-α-isomaltosidase
3.2.1.95 dextran 1,6-α-isomaltotriosidase
3.2.1.96 mannosyl-glycoprotein endo-β-N-acetylglucosaminidase
3.2.1.97 endo-α-N-acetylgalactosaminidase
3.2.1.98 glucan 1,4-α-maltohexaosidase
3.2.1.99 arabinan endo-1,5-α-L-arabinanase
3.2.1.100 mannan 1,4-mannobiosidase
3.2.1.101 mannan endo-1,6-α-mannosidase
3.2.1.102 blood-group-substance endo-1,4-β-galactosidase
3.2.1.103 keratan-sulfate endo-1,4-β-galactosidase
3.2.1.104 steryl-β-glucosidase
3.2.1.105 3α(S)-strictosidine β-glucosidase
3.2.1.106 mannosyl-oligosaccharide glucosidase
3.2.1.107 protein-glucosylgalactosylhydroxylysine glucosidase
3.2.1.108 lactase
3.2.1.109 endogalactosaminidase
3.2.1.110 mucinaminylserine mucinaminidase
3.2.1.111 1,3-α-L-fucosidase
3.2.1.112 2-deoxyglucosidase
3.2.1.113 mannosyl-oligosaccharide 1,2-α-mannosidase
3.2.1.114 mannosyl-oligosaccharide 1,3-1,6-α-mannosidase
3.2.1.115 branched-dextran exo-1,2-α-glucosidase
3.2.1.116 glucan 1,4-α-maltotriohydrolase
3.2.1.117 amygdalin β-glucosidase
3.2.1.118 prunasin β-glucosidase
3.2.1.119 vicianin β-glucosidase
3.2.1.120 oligoxyloglucan β-glycosidase
3.2.1.121 polymannuronate hydrolase
3.2.1.122 maltose-6′-phosphate glucosidase
3.2.1.123 endoglycosylceramidase
3.2.1.124 3-deoxy-2-octulosonidase
3.2.1.125 raucaffricine β-glucosidase
3.2.1.126 coniferin β-glucosidase
3.2.1.127 1,6-α-L-fucosidase
3.2.1.128 glycyrrhizin hydrolase
3.2.1.129 endo-α-sialidase
3.2.1.130 glycoprotein endo-α-1,2-mannosidase
3.2.1.131 xylan α-1,2-glucuronosidase
3.2.1.132 chitosanase
3.2.1.133 glucan 1,4-α-maltohydrolase
3.2.1.134 difructose-dianhydride-I hydrolase
3.2.1.135 neopullulanase
3.2.1.136 glucuronoarabinoxylan endo-1,4-β-xylanase
3.2.1.137 mannan exo-1,2-1,6-α-mannosidase
3.2.1.138 created 1992, deleted 2003
3.2.1.139 α-glucuronidase
3.2.1.140 lacto-N-biosidase
3.2.1.141 4-α-D-{(1→4)-α-D-glucano}trehalose trehalohydrolase
3.2.1.142 limit dextrinase
3.2.1.143 poly(ADP-ribose) glycohydrolase
3.2.1.144 3-deoxyoctulosonase
3.2.1.145 galactan 1,3-β-galactosidase
3.2.1.146 β-galactofuranosidase
3.2.1.147 thioglucosidase
3.2.1.148 created 1972 as EC 3.3.1.3, transferred 2001 to EC 3.2.1.148, deleted 2004
3.2.1.149 β-primeverosidase
3.2.1.150 oligoxyloglucan reducing-end-specific cellobiohydrolase
3.2.1.151 xyloglucan-specific endo-β-1,4-glucanase
3.2.1.152 mannosylglycoprotein endo-β-mannosidase
3.2.1.153 fructan β-(2,1)-fructosidase
3.2.1.154 fructan β-(2,6)-fructosidase
3.2.1.155 xyloglucan-specific endo-processive β-1,4-glucanase
3.2.1.156 oligosaccharide reducing-end xylanase
3.2.1.157 ι-carrageenase
3.2.1.158 α-agarase
3.2.1.159 α-neoagaro-oligosaccharide hydrolase
3.2.1.160 xyloglucan-specific exo-β-1,4-glucanase
3.2.1.161 β-apiosyl-β-glucosidase
3.2.1.162 λ-carrageenase
3.2.1.163 1,6-α-D-mannosidase
3.2.1.164 galactan endo-1,6-β-galactosidase
3.2.1.165 exo-1,4-β-D-glucosaminidase
3.2.1.166 heparanase
3.2.1.167 baicalin-β-D-glucuronidase
3.2.1.168 hesperidin 6-O-α-L-rhamnosyl-β-D-glucosidase
3.2.1.169 protein O-GlcNAcase
3.2.1.170 mannosylglycerate hydrolase
3.2.1.171 rhamnogalacturonan hydrolase
3.2.1.172 unsaturated rhamnogalacturonyl hydrolase
3.2.1.173 rhamnogalacturonan galacturonohydrolase
3.2.1.174 rhamnogalacturonan rhamnohydrolase
3.2.1.175 β-D-glucopyranosyl abscisate β-glucosidase
3.2.1.176 cellulose 1,4-β-cellobiosidase (reducing end)
3.2.1.177 α-D-xyloside xylohydrolase
3.2.1.178 β-porphyranase
3.2.1.179 gellan tetrasaccharide unsaturated glucuronosyl hydrolase
3.2.1.180 unsaturated chondroitin disaccharide hydrolase
3.2.1.181 galactan endo-β-1,3-galactanase
3.2.1.182 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside β-D-glucosidase
3.2.1.183 UDP-N-acetylglucosamine 2-epimerase (hydrolysing)
3.2.1.184 UDP-N,N′-diacetylbacillosamine 2-epimerase (hydrolysing)
3.2.1.185 non-reducing end β-L-arabinofuranosidase
3.2.1.186 protodioscin 26-O-β-D-glucosidase
3.2.1.187 (Ara-f)3-Hyp β-L-arabinobiosidase
3.2.1.188 avenacosidase
3.2.1.189 dioscin glycosidase (diosgenin-forming)
3.2.1.190 dioscin glycosidase (3-O-β-D-Glc-diosgenin-forming)
3.2.1.191 ginsenosidase type III
3.2.1.192 ginsenoside Rb1 β-glucosidase
3.2.1.193 ginsenosidase type I
3.2.1.194 ginsenosidase type IV
3.2.1.195 20-O-multi-glycoside ginsenosidase
3.2.1.196 limit dextrin α-1,6-maltotetraose-hydrolase
3.2.1.197 β-1,2-mannosidase
3.2.1.198 α-mannan endo-1,2-α-mannanase
3.2.1.199 sulfoquinovosidase
3.2.1.200 exo-chitinase (non-reducing end)
3.2.1.201 exo-chitinase (reducing end)
3.2.1.202 endo-chitodextinase
3.2.1.203 carboxymethylcellulase
3.2.1.204 1,3-α-isomaltosidase
3.2.1.205 isomaltose glucohydrolase
3.2.1.206 oleuropein β-glucosidase
3.2.1.207 mannosyl-oligosaccharide α-1,3-glucosidase
3.2.1.208 glucosylglycerate hydrolase
3.2.1.209 endoplasmic reticulum Man9GlcNAc2 1,2-α-mannosidase
3.2.1.210 endoplasmic reticulum Man8GlcNAc2 1,2-α-mannosidase
3.2.1.211 endo-(1→3)-fucoidanase
3.2.1.212 endo-(1→4)-fucoidanase
3.2.1.213 galactan exo-1,6-β-galactobiohydrolase (non-reducing end)
3.2.1.214 exo β-1,2-glucooligosaccharide sophorohydrolase (non-reducing end)
3.2.1.215 arabinogalactan exo α-(1,3)-α-D-galactosyl-(1→3)-L-arabinofuranosidase (non-reducing end)
3.2.1.216 kojibiose hydrolase
3.2.1.217 exo-acting protein-α-N-acetylgalactosaminidase
3.2.2 Hydrolysing N-glycosyl compounds
3.2.3 Hydrolysing S-glycosyl compounds (deleted sub-subclass)
3.3 Acting on ether bonds
3.4 Acting on peptide bonds (peptidases)
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.6 Acting on acid anhydrides
3.7 Acting on carbon-carbon bonds
3.8 Acting on halide bonds
3.9 Acting on phosphorus-nitrogen bonds
3.10 Acting on sulfur-nitrogen bonds
3.11 Acting on carbon-phosphorus bonds
3.12 Acting on sulfur-sulfur bonds
3.13 Acting on carbon-sulfur bonds
4 Lyases
5 Isomerases
6 Ligases
7 Translocases