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EC 2.7.11.12 Details
EC number
2.7.11.12
Accepted name
cGMP-dependent protein kinase
Reaction
ATP + a protein = ADP + a phosphoprotein
Other name(s)
3′:5′-cyclic GMP-dependent protein kinase, cGMP-dependent protein kinase Iβ, guanosine 3′:5′-cyclic monophosphate-dependent protein kinase, PKG, PKG 1α, PKG 1β, PKG II, STK23
Systematic name
ATP:protein phosphotransferase (cGMP-dependent)
CAS registry number
141588-27-4
Comment
CGMP is required to activate this enzyme. The enzyme occurs as a dimer in higher eukaryotes. The C-terminal region of each polypeptide chain contains the catalytic domain that includes the ATP and protein substrate binding sites. This domain catalyses the phosphorylation by ATP to specific serine or threonine residues in protein substrates [3]. The enzyme also has two allosteric cGMP-binding sites (sites A and B). Binding of cGMP causes a conformational change that is associated with activation of the kinase [4].
History
created 2005 (EC 2.7.1.37 part-incorporated 2005)
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