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3.4.24.42: atrolysin C

This is an abbreviated version!
For detailed information about atrolysin C, go to the full flat file.

Word Map on EC 3.4.24.42

Reaction

Cleavage of His5-/-Leu, His10-/-Leu, Ala14-/-Leu, Tyr16-/-Leu and Gly23-/-Phe bonds in B chain of insulin. With small molecule substrates prefers hydrophobic residue at P2' and small residue such as Ala, Gly at P1 =

Synonyms

aggrecanase, atrolysin, Crotalus atrox metalloendopeptidase c, hemorrhagic metalloproteinase HT-d, Hemorrhagic toxin c and d, PI metalloproteinase, Ruberlysin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.42 atrolysin C

Substrates Products

Substrates Products on EC 3.4.24.42 - atrolysin C

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-Aminobenzoyl-Ala-Gly-Leu-Ala 4-nitrobenzyl amide + H2O
?
show the reaction diagram
-
-
-
-
?
acetyl-Ala-Ala-Leu-Gly-Ala + H2O
?
show the reaction diagram
-
-
-
-
?
acetyl-Glu-Ala-Leu-Gly-Ala + H2O
?
show the reaction diagram
-
-
-
-
?
Acetyl-Val-Ala-Ala-Leu-Gly-Ala + H2O
?
show the reaction diagram
-
-
-
-
?
acetyl-Val-Ala-Leu-Gly-Gly + H2O
?
show the reaction diagram
-
-
-
-
?
Acetyl-Val-Ala-Leu-Leu-Ala + H2O
?
show the reaction diagram
-
best substrate of synthetic acetylated pentapeptides
-
-
?
acetyl-Val-Ala-Phe-Gly-Ala + H2O
?
show the reaction diagram
-
-
-
-
?
acetyl-Val-Gly-Leu-Gly-Ala + H2O
?
show the reaction diagram
-
-
-
-
?
angiotensin I + H2O
Asp-Arg-Val-Tyr-Ile-His + Pro + Phe-His-Leu
show the reaction diagram
-
i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu, cleaved at His-Pro and Pro-Phe
-
?
azocoll
?
show the reaction diagram
-
-
-
-
?
Basement membrane preparation + H2O
Soluble peptides
show the reaction diagram
Basement membranes surrounding capillaries + H2O
?
show the reaction diagram
bovine aggrecan monomer + H2O
?
show the reaction diagram
cartilage aggrecan + H2O
?
show the reaction diagram
-
-
-
?
casein + H2O
?
show the reaction diagram
-
-
-
-
?
Collagen type IV + H2O
Hydrolyzed collagen type IV
show the reaction diagram
Dimethylcasein + H2O
?
show the reaction diagram
Fibrinogen + H2O
?
show the reaction diagram
-
-
-
-
?
Fibrinogen + H2O
Hydrolyzed fibrinogen
show the reaction diagram
-
-
-
-
?
Fibronectin + H2O
?
show the reaction diagram
-
-
-
-
?
FSFRLT + H2O
?
show the reaction diagram
-
good substrate
-
-
?
Gelatin of collagen type I + H2O
Hydrolyzed gelatin of collagen type I
show the reaction diagram
Gelatin of collagen type III + H2O
?
show the reaction diagram
-
i.e. denatured collagen
-
-
?
Gelatin of collagen type V + H2O
Hydrolyzed gelatin of collagen type V
show the reaction diagram
-
i.e. denatured collagen, hydrolysis at 38øC and above, not below
MW 130000, MW 118000, MW 93000 and MW 85000 fragments
?
Glu-Ala-Leu-Tyr-Leu + H2O
?
show the reaction diagram
-
peptide derived from insulin B-chain
-
-
?
hide powder azure + H2O
?
show the reaction diagram
HTLRKA + H2O
?
show the reaction diagram
-
good substrate
-
-
?
Human alpha2-macroglobulin + H2O
?
show the reaction diagram
-
cleavage at Arg696-Leu697
-
-
?
IAQLNR + H2O
?
show the reaction diagram
-
good substrate
-
-
?
IPLRTV + H2O
?
show the reaction diagram
-
good substrate
-
-
?
Laminin + H2O
?
show the reaction diagram
Leu-Val-Glu-Ala-Leu-Tyr-Leu + H2O
Leu-Val-Glu-Ala + Leu-Tyr-Leu
show the reaction diagram
Luteinizing hormone-releasing hormone + H2O
?
show the reaction diagram
-
cleavage sites: Trp3-Ser4, Gly6-Leu7
-
-
?
Met-enkephalin + H2O
Tyr-Gly-Gly + Phe-Met
show the reaction diagram
-
i.e. Tyr-Gly-Gly-Phe-Met, cleavage site: Gly3-Phe4
-
-
?
Nidogen + H2O
?
show the reaction diagram
-
basement membrane component
-
-
?
Oxidized insulin B-chain + H2O
?
show the reaction diagram
SFMRLS + H2O
?
show the reaction diagram
-
good substrate
-
-
?
TQRKRS + H2O
?
show the reaction diagram
-
good substrate
-
-
?
Val-Glu-Ala-Leu-Tyr-Leu + H2O
?
show the reaction diagram
-
peptide derived from insulin B-chain
-
-
?
von Willebrand factor + H2O
?
show the reaction diagram
additional information
?
-