3.4.24.42: atrolysin C
This is an abbreviated version!
For detailed information about atrolysin C, go to the full flat file.
Word Map on EC 3.4.24.42
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3.4.24.42
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cartilage
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articular
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osteoarthritis
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joint
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chondrocytes
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proteoglycans
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explants
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metalloproteinases
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collagen
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adamts-4
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glycosaminoglycans
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thrombospondin
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synovial
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disintegrin
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knee
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neoepitope
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interglobular
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arthritic
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mmp-1
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aggrecanolysis
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chondroitin
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aggrecan-degrading
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timp-3
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nitege
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versican
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disintegrin-like
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interleukin-1alpha
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chondroprotective
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igd
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matrix-degrading
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adamalysin
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subchondral
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meniscal
- 3.4.24.42
- cartilage
-
articular
- osteoarthritis
- joint
- chondrocytes
- proteoglycans
-
explants
- metalloproteinases
- collagen
- adamts-4
- glycosaminoglycans
- thrombospondin
- synovial
-
disintegrin
- knee
-
neoepitope
-
interglobular
-
arthritic
- mmp-1
-
aggrecanolysis
- chondroitin
-
aggrecan-degrading
- timp-3
-
nitege
- versican
-
disintegrin-like
- interleukin-1alpha
-
chondroprotective
- igd
-
matrix-degrading
- adamalysin
-
subchondral
-
meniscal
Reaction
Cleavage of His5-/-Leu, His10-/-Leu, Ala14-/-Leu, Tyr16-/-Leu and Gly23-/-Phe bonds in B chain of insulin. With small molecule substrates prefers hydrophobic residue at P2' and small residue such as Ala, Gly at P1 =
Synonyms
aggrecanase, atrolysin, Crotalus atrox metalloendopeptidase c, hemorrhagic metalloproteinase HT-d, Hemorrhagic toxin c and d, PI metalloproteinase, Ruberlysin
ECTree
3.4.24.42 atrolysin CAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.4.24.42 - atrolysin C
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
von Willebrand factor + H2O
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VWF is a large, multidomain glycoprotein present in human blood and in the secretory granules of endothelial cells and platelets
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?
Basement membranes surrounding capillaries + H2O
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involved in disruption of capillary membranes causing hemorrhage in surrounding tissue
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?
Basement membranes surrounding capillaries + H2O
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together with hemorrhagic toxins a, b, e and f responsible for hemorrhage
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?
Basement membranes surrounding capillaries + H2O
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together with atrolysins B and E member of the class P-I hemorrhagic toxins
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?
Basement membranes surrounding capillaries + H2O
?
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less potent hemorrhagic toxins of Crotalus atrox venom
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?
