3.4.24.36: leishmanolysin

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For detailed information about leishmanolysin, go to the full flat file.

Word Map on EC 3.4.24.36

3.4.24.36

promastigotes

pneumocystis

leishmaniasis

carinii

donovani

trypanosoma

amastigotes

jirovecii

mexicana

chaga

pcp

guanidinobenzoatase

infantum

lipophosphoglycan

metacyclic

braziliensis

complement-mediated

phagolysosome

amazonensis

rat-derived

9-amino

tsetse

viannia

leishmanial

medicine

procyclins

pharmacology

Reaction

Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-/-Leu-Lys-Lys- =

Synonyms

66 kDa surface metallopeptidase, Cell surface protease, glycoprotein 63, Glycoprotein gp63, gp63, GP63 metalloprotease, GP63 protein, GP63 surface metalloprotease, GP63 virulence protein, Leishmania metalloproteinase, Leishmania surface metalloprotease, leishmanolysin-like molecule, Major surface glycoprotein, major surface protease, major surface-metalloprotease, metalloprotease GP63, MSP, Promastigote surface endopeptidase, Promastigote surface protease, protective surface protease, Surface acid proteinase, surface leishmanolysin-like molecule, surface protease GP63, surface protein GP63, surface proteinase GP63, virulence factor major surface protease

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.36 leishmanolysin

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Results	in table
1	Activating Compound
559	AA Sequence
12	Application
1	CAS Registry Number
5	Cloned(Commentary)
4	Crystallization (Commentary)
17	General Information
1	General Stability
14	Inhibitors
9	kcat/KM [mM/s]
10	KM Value [mM]
55	Localization
13	Metals/Ions
10	Molecular Weight [Da]
32	Natural Substrates/ Products (Substrates)
104	Organism
1	PDB ID
12	pH Optimum
4	pH Range
1	pH Stability
5	pI Value
8	Posttranslational Modification
14	Protein Variants
7	Purification (Commentary)
1	Reaction
1	Reaction Type
54	Reference
49	Source Tissue
1	Storage Stability
90	Substrates and Products (Substrate)
9	Subunits
182	Synonyms
10	Temperature Optimum [°C]
9	Turnover Number [1/s]

pI Value

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pI Value on EC 3.4.24.36 - leishmanolysin

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5.32

MSPC

5.65

MSPS and MSPL

5.8 - 6.7

8 different bands of isozymes within this range

6.4

calculated

additional information

2 entries