3.4.24.36: leishmanolysin

This is an abbreviated version!
For detailed information about leishmanolysin, go to the full flat file.

Reaction

Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-/-Leu-Lys-Lys- =

Synonyms

66 kDa surface metallopeptidase, Cell surface protease, glycoprotein 63, Glycoprotein gp63, gp63, GP63 metalloprotease, GP63 protein, GP63 surface metalloprotease, GP63 virulence protein, Leishmania metalloproteinase, Leishmania surface metalloprotease, leishmanolysin-like molecule, Major surface glycoprotein, major surface protease, major surface-metalloprotease, metalloprotease GP63, MSP, Promastigote surface endopeptidase, Promastigote surface protease, protective surface protease, Surface acid proteinase, surface leishmanolysin-like molecule, surface protease GP63, surface protein GP63, surface proteinase GP63, virulence factor major surface protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.36 leishmanolysin

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Results	in table
1	Activating Compound
559	AA Sequence
12	Application
1	CAS Registry Number
5	Cloned(Commentary)
4	Crystallization (Commentary)
17	General Information
1	General Stability
14	Inhibitors
9	kcat/KM [mM/s]
10	KM Value [mM]
55	Localization
13	Metals/Ions
10	Molecular Weight [Da]
32	Natural Substrates/ Products (Substrates)
104	Organism
1	PDB ID
12	pH Optimum
4	pH Range
1	pH Stability
5	pI Value
8	Posttranslational Modification
14	Protein Variants
7	Purification (Commentary)
1	Reaction
1	Reaction Type
54	Reference
49	Source Tissue
1	Storage Stability
90	Substrates and Products (Substrate)
9	Subunits
182	Synonyms
10	Temperature Optimum [°C]
9	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 3.4.24.36 - leishmanolysin

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MOLECULAR WEIGHT

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

51674

Leishmania chagasi

-

x * 59177, MSPC, sequence calculation, x * 51689, MSPS, sequence calculation, x * 51674, MSPL, sequence calculation

683857

51689

Leishmania chagasi

-

x * 59177, MSPC, sequence calculation, x * 51689, MSPS, sequence calculation, x * 51674, MSPL, sequence calculation

683857

52000

Leishmania major

-

x * 52000, Leishmania major, deglycosylated enzyme, x * 53200, Leishmania major, deglycosylated enzyme, SDS-PAGE

31228

52570

Leishmania major

-

Leishmania major, calculated from nucleotide sequence plus carbohydrate core of GPI anchor

31228

53200

Leishmania major

-

x * 52000, Leishmania major, deglycosylated enzyme, x * 53200, Leishmania major, deglycosylated enzyme, SDS-PAGE

31228

59177

Leishmania chagasi

-

x * 59177, MSPC, sequence calculation, x * 51689, MSPS, sequence calculation, x * 51674, MSPL, sequence calculation

683857

62950

Leishmania donovani

P23223

x * 62950, calculated

696516

63000

Leishmania major

-

SDS-PAGE

651945

66000

Herpetomonas pessoai

-

x * 66000, SDS-PAGE

710519

additional information

Leishmania major

-

microheterogeneity in MW and charge

31228