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3.4.24.36: leishmanolysin

This is an abbreviated version!
For detailed information about leishmanolysin, go to the full flat file.

Word Map on EC 3.4.24.36

Reaction

Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-/-Leu-Lys-Lys- =

Synonyms

66 kDa surface metallopeptidase, Cell surface protease, glycoprotein 63, Glycoprotein gp63, gp63, GP63 metalloprotease, GP63 protein, GP63 surface metalloprotease, GP63 virulence protein, Leishmania metalloproteinase, Leishmania surface metalloprotease, leishmanolysin-like molecule, Major surface glycoprotein, major surface protease, major surface-metalloprotease, metalloprotease GP63, MSP, Promastigote surface endopeptidase, Promastigote surface protease, protective surface protease, Surface acid proteinase, surface leishmanolysin-like molecule, surface protease GP63, surface protein GP63, surface proteinase GP63, virulence factor major surface protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.36 leishmanolysin

Engineering

Engineering on EC 3.4.24.36 - leishmanolysin

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
F448V
site-directed mutagenesis, the mutant shows activity similar to the wild-type enzyme
F448Y
site-directed mutagenesis, the mutant shows activity similar to the wild-type enzyme
S446A
site-directed mutagenesis, the mutant shows 50% reduced activity and altered kinetics compared to the wild-type enzyme
S446T
site-directed mutagenesis, the mutant shows activity similar to the wild-type enzyme
F448V
-
site-directed mutagenesis, the mutant shows activity similar to the wild-type enzyme
-
F448Y
-
site-directed mutagenesis, the mutant shows activity similar to the wild-type enzyme
-
S446A
-
site-directed mutagenesis, the mutant shows 50% reduced activity and altered kinetics compared to the wild-type enzyme
-
S446T
-
site-directed mutagenesis, the mutant shows activity similar to the wild-type enzyme
-
additional information