3.4.23.40: Phytepsin

This is an abbreviated version!
For detailed information about Phytepsin, go to the full flat file.

Reaction

Prefers hydrophobic residues Phe, Val, Ile, Leu, and Ala at P1 and P1', but also cleaves -Phe-/-Asp- and -Asp-/-Asp- bonds in 2S albumin from plant seeds =

Synonyms

Acid protease, Ap1, Aspartic proteinase, Aspartyl endoproteinase, Barley grain aspartic proteinase, Carboxyl proteinase, CardA, cardB, Cardosin, cardosin A, cardosin B, Cynarase, cynarase A, cynarase B, cynarase C, Edestinase, HvAP, Nepenthesin, Oryzasin, PCB, procardosin B

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.40 Phytepsin

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Results	in table
63	AA Sequence
3	Application
1	CAS Registry Number
4	Cloned(Commentary)
2	Crystallization (Commentary)
2	Expression
2	General Information
15	Inhibitors
7	kcat/KM [mM/s]
4	Ki Value [mM]
10	KM Value [mM]
2	Localization
48	Molecular Weight [Da]
19	Natural Substrates/ Products (Substrates)
43	Organism
3	PDB ID
31	pH Optimum
6	pH Range
1	pH Stability
4	pI Value
8	Posttranslational Modification
1	Protein Variants
5	Purification (Commentary)
1	Reaction
1	Reaction Type
43	Reference
39	Source Tissue
2	Specific Activity [micromol/min/mg]
2	Storage Stability
68	Substrates and Products (Substrate)
16	Subunits
24	Synonyms
5	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Temperature Stability [°C]
9	Turnover Number [1/s]

General Information

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General Information on EC 3.4.23.40 - Phytepsin

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

metabolism

Cynara cardunculus

Q9XFX3

either the plant-specific insert domain or the C-terminal peptide VGFAEAA is necessary and sufficient to direct proteins to the vacuole. Both domains are vacuolar sorting determinants

734915

physiological function

Cynara cardunculus

-

epithelial A549 cell-bound cardosin A is internalized to endosomes and lysosomes and triggers the permeability of lysosomal membrane leading to apoptosis of the epithelial cells. The enzyme may have a defensive function against the ingestion of cardoon flowers by human, insects, and other herbivores

755355