3.4.23.24: Candidapepsin

This is an abbreviated version!
For detailed information about Candidapepsin, go to the full flat file.

Word Map on EC 3.4.23.24

3.4.23.24

alzheimer

amyloid

cathepsins

gamma-secretase

presenilins

pepstatin

abeta

candidiasis

beta-secretase

renin

intramembrane

beta-amyloid

hyphal

notch

nicastrin

beta-site

parapsilosis

beta-peptide

bace-1

amyloid-beta

fluconazole

tropicalis

peptidomimetic

dubliniensis

app-cleaving

broom

ritonavir

endoproteolysis

witches

plasmepsin

beta-protein

phytoplasmas

secretase

intramembrane-cleaving

indinavir

endothiapepsin

medicine

saquinavir

prorenin

hydroxyethylamine

vulvovaginal

isostere

Reaction

Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave Leu15-Tyr, Tyr16-Leu and Phe24-Phe of insulin B chain. Activates trypsinogen, and degrades keratin =

Synonyms

Aspartate protease, aspartic protease, aspartic protease 2, aspartic protease Sap2p, aspartic proteinase 3, aspartyl protease, aspartyl protease Sap2p, aspartyl protease Sap4, aspartyl protease Sap5, aspartyl protease Sap6, aspartyl proteinase, candialbicin, Candida albicans aspartic proteinase, Candida albicans carboxyl proteinase, Candida albicans secretory acid proteinase, Candida albicans-secreted aspartic proteinase, Candida olea acid proteinase, Candidapepsin-1, candidapepsin-2, EC 3.4.23.6, EC 3.4.4.17, Proteinase, Candida albicans aspartic, Proteinase, Candida aspartic, Proteinase, Candida olea aspartic, S-aspartyl proteinase, SAP, SAP1, Sap10, SAP11, Sap1p, SAP2, Sap2p, SAP2X, SAP3, Sap3p, SAP4, Sap4p, SAP5, Sap5p, SAP6, Sap6p, Sap7, Sap7p, Sap8, Sap8p, Sap9, Sap9p, SAPP1, Sapp1p, SAPP2, Sapp2p, SAPP3, SAPT1, Sapt1p, SAPT2, SAPT3, SAPT4, secreted aspartic protease, secreted aspartic protease 1, secreted aspartic protease 2, secreted aspartic proteinase, secreted aspartic proteinase 1, secreted aspartic proteinase 2, secreted aspartic proteinase-2, secreted aspartyl peptidase, secreted aspartyl protease, secreted aspartyl protease 9, secreted aspartyl proteinase, secreted aspartyl proteinase 2, secreted aspartyl proteinase 5, secreted aspartyl proteinase2, secreted aspartyl proteinases, secreted aspartyl-type peptidase, secretory aspartyl proteinase, secretory aspartyl proteinase SAP1, secretory aspartyl proteinase SAP2p, secretory aspartyl proteinase SAP3p, secretory aspartyl proteinase SAP4p, secretory aspartyl proteinase SAP5p, secretory aspartyl proteinase SAP6p, yapsin, Yps

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.23 Aspartic endopeptidases

3.4.23.24 Candidapepsin

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Results	in table
3	Activating Compound
362	AA Sequence
4	Application
1	CAS Registry Number
18	Cloned(Commentary)
7	Crystallization (Commentary)
7	Expression
16	General Information
5	General Stability
2	IC50 Value
144	Inhibitors
33	Ki Value [mM]
8	KM Value [mM]
19	Localization
47	Molecular Weight [Da]
29	Natural Substrates/ Products (Substrates)
128	Organism
37	PDB ID
19	pH Optimum
1	pH Range
6	pH Stability
2	pI Value
10	Posttranslational Modification
15	Purification (Commentary)
1	Reaction
3	Reaction Type
97	Reference
1	Renatured (Commentary)
19	Source Tissue
4	Specific Activity [micromol/min/mg]
1	Storage Stability
142	Substrates and Products (Substrate)
24	Subunits
259	Synonyms
2	Temperature Optimum [°C]
1	Temperature Range [°C]
7	Temperature Stability [°C]
5	Turnover Number [1/s]

Sequence

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Sequence on EC 3.4.23.24 - Candidapepsin

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Q5A651 pBLAST

CAR10_CANAL

Candida albicans (strain SC5314 / ATCC MYA-2876)

453

49333

Swiss-Prot