3.4.23.20: Penicillopepsin

This is an abbreviated version!
For detailed information about Penicillopepsin, go to the full flat file.

Reaction

Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving Gly20-/-Glu in the B chain of insulin. Clots milk, and activates trypsinogen =

Synonyms

Acid protease A, EC 3.4.23.6, EC 3.4.23.7, EC 3.4.4.17, mold kinase, More, pencillopepsin-JT1, pencillopepsin-JT2, Penicillium citrinum acid proteinase, Penicillium cyclopium acid proteinase, Penicillium expansum acid proteinase, Penicillium janthinellum acid proteinase, Penicillium janthinellum aspartic proteinase, penicillium kinase, Penicillium roqueforti acid proteinase, penicillopepsin-JT1, penicillopepsin-JT2, penicillopepsin-JT3, PEP, PepA, Peptidase A, Proteinase, Penicillium aspartic, Proteinase, Penicillium caseicolum aspartic, Proteinase, Penicillium citrinum aspartic, Proteinase, Penicillium cyclopium acid, Proteinase, Penicillium duponti aspartic, Proteinase, Penicillium expansum aspartic, Proteinase, Penicillium janthinellum acid, Proteinase, Penicillium roqueforti aspartic

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.20 Penicillopepsin

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Results	in table
3	Activating Compound
180	AA Sequence
3	Application
1	CAS Registry Number
4	Cloned(Commentary)
11	Crystallization (Commentary)
61	Inhibitors
9	Ki Value [mM]
63	KM Value [mM]
2	Localization
6	Metals/Ions
13	Molecular Weight [Da]
47	Organism
14	PDB ID
11	pH Optimum
3	pH Range
15	pH Stability
2	pI Value
11	Posttranslational Modification
12	Protein Variants
12	Purification (Commentary)
1	Reaction
1	Reaction Type
40	Reference
3	Specific Activity [micromol/min/mg]
1	Storage Stability
71	Substrates and Products (Substrate)
12	Subunits
41	Synonyms
9	Temperature Optimum [°C]
3	Temperature Range [°C]
10	Temperature Stability [°C]
64	Turnover Number [1/s]

pH Stability

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pH Stability on EC 3.4.23.20 - Penicillopepsin

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pH STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

2 - 7

Penicillium janthinellum

-

rapid loss of activity below pH 2.0 and above pH 7.0

30585

2.5

Penicillium duponti

-

65°C, complete loss of activity after 15 min, 60°C, complete loss of activity after 60 min

30586

2.5 - 6

Penicillium duponti

-

30°C, 20 h, stable

30595

2.5 - 6.5

Penicillium duponti

-

30°C, 24 h, stable

30586

3

Penicillium janthinellum

-

37°C, slow inactivation

30585

3 - 7

Penicillium canescens

-

the enzyme maintains more than 70% activity after incubation for 24 h at pH 3.0-7.0 25°C

752532

3.5 - 5.5

Penicillium duponti

-

60°C, 1 h, stable

30586, 30595

4.5

3 entries

4.9

Penicillium janthinellum

-

55°C, 1 h, stable

30585

6 - 11

Penicillium aurantiogriseum

-

the purified enzyme does not lose any activity after 24 h at pH 6.0-11.0

755308

6.1

Penicillium janthinellum

-

37°C, slow inactivation

30585

8 - 9

Penicillium candidum

-

the enzyme retains less than 35% activity after 1 h at pH 8.0-9.0

753904

4.5

Penicillium duponti

-

at 65°C, stable for 15 min, at 60°C, stable for 60 min

30586

4.5

Penicillium duponti

-

70°C, 1 h, more than 65% of the activity is retained

30595

4.5

Penicillium duponti

-

80°C, 10 min, complete inactivation

30595