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3.4.23.20: Penicillopepsin

This is an abbreviated version!
For detailed information about Penicillopepsin, go to the full flat file.

Word Map on EC 3.4.23.20

Reaction

Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving Gly20-/-Glu in the B chain of insulin. Clots milk, and activates trypsinogen =

Synonyms

Acid protease A, EC 3.4.23.6, EC 3.4.23.7, EC 3.4.4.17, mold kinase, More, pencillopepsin-JT1, pencillopepsin-JT2, Penicillium citrinum acid proteinase, Penicillium cyclopium acid proteinase, Penicillium expansum acid proteinase, Penicillium janthinellum acid proteinase, Penicillium janthinellum aspartic proteinase, penicillium kinase, Penicillium roqueforti acid proteinase, penicillopepsin-JT1, penicillopepsin-JT2, penicillopepsin-JT3, PEP, PepA, Peptidase A, Proteinase, Penicillium aspartic, Proteinase, Penicillium caseicolum aspartic, Proteinase, Penicillium citrinum aspartic, Proteinase, Penicillium cyclopium acid, Proteinase, Penicillium duponti aspartic, Proteinase, Penicillium expansum aspartic, Proteinase, Penicillium janthinellum acid, Proteinase, Penicillium roqueforti aspartic

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.20 Penicillopepsin

Temperature Stability

Temperature Stability on EC 3.4.23.20 - Penicillopepsin

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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25 - 45
-
the purified enzyme does not lose any activity over 48 h at 25°C. The protease shows an activity loss of 77.56% at 45°C after 12 h
30 - 50
-
the enzyme remains stable after 80 min incubation at 30-50°C (pH 5.0). The activity drops to less than 20% after 80 min at 60°C. The enzyme shows about 75% activity after 2 h at 50°C
37
-
pH 3.0 or pH 6.1, slow inactivation
55
-
pH 4.9, 1 h, stable
60
Penicillium duponti
-
pH 3.5-5.5, 1 h, stable
70
Penicillium duponti
-
pH 4.5, 1 h, more than 65% of activity is retained
80
Penicillium duponti
-
pH 4.5, 10 min, complete inactivation