3.4.22.B70: SENP1 peptidase

This is an abbreviated version!
For detailed information about SENP1 peptidase, go to the full flat file.

Word Map on EC 3.4.22.B70

3.4.22.B70

desumoylation

deconjugating

senp-1

medicine

sumo-modified

senp1-mediated

drug development

ranbp2

sumo-2

diagnostics

Reaction

The enzyme catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO-1, SUMO-2 and SUMO-3 to their mature forms and deconjugation of SUMO-1, SUMO-2 and SUMO-3 from targeted proteins. Deconjugates SUMO-1 from homeodomain-interacting protein kinase 2. Deconjugates SUMO-1 from histone deacetylase 1, which decreases its transcriptional repression activity. Cleavage of Gly97-/-His98 bond in the SUMO-1 precursor with release of the propeptide His-Ser-Thr-Val. Cleavage of Gly93-/-Val94 bond in the SUMO-2 precursor with release of the propeptide Val94-Thyr. Cleavage of the Gly92-/-Val93 in the SUMO-3 precursor with release of the propeptide Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe. =

Synonyms

C13orf22l, SENP, SENP1, sentrin-specific protease 1, sentrin/SUMO-specific protease 1, small ubiquitin-like modifier protein-specific protease 1, small ubiquitin-related modifier-specific isopeptidase, SUMO isopeptidase, SUMO protease, SUMO protein-specific protease 1, SUMO-specific isopeptidase, SUMO-specific protease, SUMO-specific protease 1, ubiquitin-specific protease-like 1, USPL1

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.B70 SENP1 peptidase

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Results	in table
1	Activating Compound
3	AA Sequence
11	Application
14	Cloned(Commentary)
3	Crystallization (Commentary)
106	Disease/ Diagnostics
6	Expression
48	General Information
21	IC50 Value
47	Inhibitors
5	KM Value [mM]
19	Localization
2	Metals/Ions
1	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
46	Organism
2	pH Optimum
1	Posttranslational Modification
27	Protein Variants
6	Purification (Commentary)
1	Reaction
46	Reference
39	Source Tissue
67	Substrates and Products (Substrate)
1	Subunits
54	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
4	Turnover Number [1/s]

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